| Full name: proteasome 26S subunit, ATPase 3 | Alias Symbol: TBP1|TBP-1 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 5702 | HGNC ID: HGNC:9549 | Ensembl Gene: ENSG00000165916 | OMIM ID: 186852 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMC3 | 5702 | 201267_s_at | 0.2895 | 0.4278 | |
| GSE20347 | PSMC3 | 5702 | 201267_s_at | -0.1191 | 0.5406 | |
| GSE23400 | PSMC3 | 5702 | 201267_s_at | 0.2524 | 0.0050 | |
| GSE26886 | PSMC3 | 5702 | 201267_s_at | -0.4873 | 0.1140 | |
| GSE29001 | PSMC3 | 5702 | 201267_s_at | 0.3832 | 0.3672 | |
| GSE38129 | PSMC3 | 5702 | 201267_s_at | 0.1377 | 0.5411 | |
| GSE45670 | PSMC3 | 5702 | 201267_s_at | 0.1939 | 0.2484 | |
| GSE53622 | PSMC3 | 5702 | 132210 | 0.2386 | 0.0002 | |
| GSE53624 | PSMC3 | 5702 | 132210 | 0.3597 | 0.0000 | |
| GSE63941 | PSMC3 | 5702 | 201267_s_at | 1.0690 | 0.0225 | |
| GSE77861 | PSMC3 | 5702 | 201267_s_at | 0.3429 | 0.2272 | |
| GSE97050 | PSMC3 | 5702 | A_23_P104607 | 0.1301 | 0.6644 | |
| SRP007169 | PSMC3 | 5702 | RNAseq | 1.6948 | 0.0066 | |
| SRP008496 | PSMC3 | 5702 | RNAseq | 1.7818 | 0.0006 | |
| SRP064894 | PSMC3 | 5702 | RNAseq | 0.6021 | 0.0068 | |
| SRP133303 | PSMC3 | 5702 | RNAseq | 0.4327 | 0.0043 | |
| SRP159526 | PSMC3 | 5702 | RNAseq | 0.3878 | 0.1351 | |
| SRP193095 | PSMC3 | 5702 | RNAseq | 0.1204 | 0.3249 | |
| SRP219564 | PSMC3 | 5702 | RNAseq | 0.0546 | 0.8821 | |
| TCGA | PSMC3 | 5702 | RNAseq | 0.1258 | 0.0075 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PSMC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMC3 | 5702 | 3 | 7 | 20 | |
| GSE20123 | PSMC3 | 5702 | 3 | 6 | 21 | |
| GSE43470 | PSMC3 | 5702 | 1 | 4 | 38 | |
| GSE46452 | PSMC3 | 5702 | 8 | 5 | 46 | |
| GSE47630 | PSMC3 | 5702 | 3 | 9 | 28 | |
| GSE54993 | PSMC3 | 5702 | 3 | 0 | 67 | |
| GSE54994 | PSMC3 | 5702 | 1 | 11 | 41 | |
| GSE60625 | PSMC3 | 5702 | 0 | 0 | 11 | |
| GSE74703 | PSMC3 | 5702 | 1 | 2 | 33 | |
| GSE74704 | PSMC3 | 5702 | 2 | 4 | 14 | |
| TCGA | PSMC3 | 5702 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of PSMC3:
Generating mutation plots.
Highly correlated genes for PSMC3:
Showing top 20/818 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMC3 | COMMD7 | 0.813886 | 3 | 0 | 3 |
| PSMC3 | FAM171B | 0.788968 | 3 | 0 | 3 |
| PSMC3 | ATG4C | 0.785149 | 4 | 0 | 4 |
| PSMC3 | ALG1 | 0.774258 | 3 | 0 | 3 |
| PSMC3 | RAD18 | 0.772288 | 3 | 0 | 3 |
| PSMC3 | EFCAB7 | 0.762085 | 3 | 0 | 3 |
| PSMC3 | USP37 | 0.755051 | 3 | 0 | 3 |
| PSMC3 | FBXO33 | 0.754571 | 3 | 0 | 3 |
| PSMC3 | MOB3C | 0.752105 | 3 | 0 | 3 |
| PSMC3 | ALG10 | 0.749228 | 3 | 0 | 3 |
| PSMC3 | FASTKD5 | 0.742688 | 3 | 0 | 3 |
| PSMC3 | MRPL38 | 0.737644 | 3 | 0 | 3 |
| PSMC3 | COA5 | 0.730793 | 3 | 0 | 3 |
| PSMC3 | CENPBD1 | 0.729272 | 3 | 0 | 3 |
| PSMC3 | SLC25A33 | 0.726768 | 3 | 0 | 3 |
| PSMC3 | NUB1 | 0.715948 | 4 | 0 | 4 |
| PSMC3 | MRPS26 | 0.710041 | 3 | 0 | 3 |
| PSMC3 | PTPMT1 | 0.709292 | 7 | 0 | 6 |
| PSMC3 | TCEA2 | 0.708939 | 3 | 0 | 3 |
| PSMC3 | KTI12 | 0.708316 | 3 | 0 | 3 |
For details and further investigation, click here
