GATA3

 

Full name: GATA binding protein 3 Alias Symbol: HDR
Type: protein-coding gene Cytoband: 10p14
Entrez ID: 2625 HGNC ID: HGNC:4172 Ensembl Gene: ENSG00000107485 OMIM ID: 131320
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 11/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GATA3 involved pathways:

KEGG pathway Description View
hsa05321Inflammatory bowel disease (IBD)

 

Expression of GATA3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GATA3 2625 209604_s_at 0.7107 0.6919
GSE20347 GATA3 2625 209604_s_at 0.2372 0.3385
GSE23400 GATA3 2625 209604_s_at 0.0454 0.5131
GSE26886 GATA3 2625 209604_s_at 1.1410 0.0761
GSE29001 GATA3 2625 209604_s_at 0.5242 0.1186
GSE38129 GATA3 2625 209604_s_at 0.2325 0.2507
GSE45670 GATA3 2625 209604_s_at 0.4567 0.3677
GSE53622 GATA3 2625 98592 0.1825 0.4042
GSE53624 GATA3 2625 98592 0.2791 0.1212
GSE63941 GATA3 2625 209604_s_at 1.7728 0.1675
GSE77861 GATA3 2625 209604_s_at -0.1453 0.2571
GSE97050 GATA3 2625 A_33_P3360341 0.1087 0.5553
SRP064894 GATA3 2625 RNAseq 0.9309 0.0003
SRP133303 GATA3 2625 RNAseq 0.5526 0.0639
SRP159526 GATA3 2625 RNAseq -0.2915 0.6788
SRP219564 GATA3 2625 RNAseq 1.4946 0.0069
TCGA GATA3 2625 RNAseq 1.0602 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by GATA3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GATA3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GATA3 2625 4 8 18
GSE20123 GATA3 2625 4 7 19
GSE43470 GATA3 2625 3 6 34
GSE46452 GATA3 2625 2 14 43
GSE47630 GATA3 2625 5 15 20
GSE54993 GATA3 2625 11 0 59
GSE54994 GATA3 2625 4 10 39
GSE60625 GATA3 2625 0 0 11
GSE74703 GATA3 2625 2 4 30
GSE74704 GATA3 2625 1 6 13
TCGA GATA3 2625 19 26 51

Total number of gains: 55; Total number of losses: 96; Total Number of normals: 337.  

 

Somatic mutations of GATA3:

 

Generating mutation plots.

 

Highly correlated genes for GATA3:

 

Showing top 20/162 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GATA3MADD0.760741303
GATA3SPIC0.724049303
GATA3SBK10.702807303
GATA3HNRNPUL10.701965303
GATA3ZNF7890.698143303
GATA3TIMM8A0.690572303
GATA3LRRC560.68825303
GATA3MED120.678026303
GATA3NAT100.672822303
GATA3KDM5A0.672084303
GATA3NPRL20.669518303
GATA3HIVEP10.660012303
GATA3HS6ST10.657773303
GATA3KRT370.65581303
GATA3CCDC1670.653746303
GATA3PABPC4L0.640577403
GATA3ZNF5810.639807403
GATA3RING10.639167303
GATA3CEP2500.636715404
GATA3CCDC970.63541403

For details and further investigation, click here