Full name: Spi-C transcription factor	Alias Symbol: MGC40611|SPI-C
Type: protein-coding gene	Cytoband: 12q23.2
Entrez ID: 121599	HGNC ID: HGNC:29549	Ensembl Gene: ENSG00000166211	OMIM ID: 612568
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 17/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of SPIC:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	SPIC	121599	1553851_at	0.0726	0.7398	Show
GSE26886	SPIC	121599	1553851_at	0.2979	0.1122	Show
GSE45670	SPIC	121599	1553851_at	0.0851	0.2885	Show
GSE53622	SPIC	121599	120309	-0.2000	0.3759	Show
GSE53624	SPIC	121599	120309	-0.5172	0.0050	Show
GSE63941	SPIC	121599	1553851_at	0.0690	0.6111	Show
GSE77861	SPIC	121599	1553851_at	-0.0641	0.3051	Show
GSE97050	SPIC	121599	A_32_P148275	0.4625	0.2462	Show
TCGA	SPIC	121599	RNAseq	1.1588	0.3396	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by SPIC expression:

 

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Copy number change of SPIC:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	SPIC	121599	2	2	26	Show
GSE20123	SPIC	121599	2	2	26	Show
GSE43470	SPIC	121599	2	0	41	Show
GSE46452	SPIC	121599	9	1	49	Show
GSE47630	SPIC	121599	9	1	30	Show
GSE54993	SPIC	121599	0	5	65	Show
GSE54994	SPIC	121599	4	2	47	Show
GSE60625	SPIC	121599	0	0	11	Show
GSE74703	SPIC	121599	2	0	34	Show
GSE74704	SPIC	121599	1	2	17	Show
TCGA	SPIC	121599	19	10	67	Show

Total number of gains: 50; Total number of losses: 25; Total Number of normals: 413.  Download Data

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Somatic mutations of SPIC:

 

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Highly correlated genes for SPIC:

 

Showing top 20/87 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
SPIC	KCND1	0.786106	3	0	3
SPIC	GAL	0.774771	3	0	3
SPIC	CEP250	0.773391	3	0	3
SPIC	SCML4	0.768704	3	0	3
SPIC	MRPL1	0.759752	3	0	3
SPIC	PLAG1	0.758486	3	0	3
SPIC	ATG13	0.738302	3	0	3
SPIC	EHMT2	0.735498	3	0	3
SPIC	RCHY1	0.733697	3	0	3
SPIC	IRX3	0.732736	3	0	3
SPIC	MLLT1	0.729434	3	0	3
SPIC	POLR2K	0.728898	3	0	3
SPIC	APEX1	0.727179	3	0	3
SPIC	GATA3	0.724049	3	0	3
SPIC	CNIH3	0.722642	3	0	3
SPIC	ZNF432	0.719913	3	0	3
SPIC	TBC1D23	0.719575	3	0	3
SPIC	FNBP1L	0.713952	3	0	3
SPIC	ZNF581	0.712963	3	0	3
SPIC	IL18BP	0.709671	3	0	3

For details and further investigation, click here