MED12

 

Full name: mediator complex subunit 12 Alias Symbol: CAGH45|HOPA|OPA1|TRAP230|KIAA0192|OKS
Type: protein-coding gene Cytoband: Xq13.1
Entrez ID: 9968 HGNC ID: HGNC:11957 Ensembl Gene: ENSG00000184634 OMIM ID: 300188
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 123/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MED12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MED12 9968 216071_x_at 0.3196 0.4600
GSE20347 MED12 9968 216071_x_at 0.0041 0.9669
GSE23400 MED12 9968 211342_x_at -0.0506 0.3521
GSE26886 MED12 9968 211342_x_at 0.2555 0.1084
GSE29001 MED12 9968 211342_x_at -0.0367 0.9090
GSE38129 MED12 9968 211342_x_at -0.0616 0.5018
GSE45670 MED12 9968 216071_x_at 0.0548 0.7084
GSE53622 MED12 9968 33587 0.1409 0.0315
GSE53624 MED12 9968 6252 0.0674 0.2052
GSE63941 MED12 9968 216071_x_at 0.3260 0.3796
GSE77861 MED12 9968 211342_x_at -0.0975 0.5776
GSE97050 MED12 9968 A_23_P73702 0.1194 0.5726
SRP007169 MED12 9968 RNAseq 0.9527 0.0466
SRP008496 MED12 9968 RNAseq 0.6360 0.0722
SRP064894 MED12 9968 RNAseq 0.1331 0.5380
SRP133303 MED12 9968 RNAseq -0.1075 0.4973
SRP159526 MED12 9968 RNAseq 0.0735 0.8008
SRP193095 MED12 9968 RNAseq 0.1557 0.1322
SRP219564 MED12 9968 RNAseq 0.0474 0.8943
TCGA MED12 9968 RNAseq -0.0290 0.5156

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MED12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MED12:

 

No record found for this gene.

 

Somatic mutations of MED12:

 

Generating mutation plots.

 

Highly correlated genes for MED12:

 

Showing top 20/279 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MED12PLD30.802682303
MED12ZNF8300.794514303
MED12LY6E0.778452303
MED12TG0.765935303
MED12PIAS30.758555404
MED12SLFNL10.754027303
MED12PLEKHA40.743182404
MED12SPI10.73915303
MED12RNFT20.738774303
MED12ZDHHC140.732761404
MED12GDI10.727829404
MED12SLC25A290.727569303
MED12NUCB10.721383404
MED12REC80.717641303
MED12MAN2B10.712352303
MED12TNFRSF90.711249404
MED12COMT0.708735303
MED12SUGP10.707329404
MED12THBS40.706707303
MED12POLR1C0.705689303

For details and further investigation, click here