| Full name: heparan sulfate 6-O-sulfotransferase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q14.3 | ||
| Entrez ID: 9394 | HGNC ID: HGNC:5201 | Ensembl Gene: ENSG00000136720 | OMIM ID: 604846 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HS6ST1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HS6ST1 | 9394 | 225263_at | 0.8254 | 0.0986 | |
| GSE20347 | HS6ST1 | 9394 | 206997_s_at | -0.0313 | 0.7629 | |
| GSE23400 | HS6ST1 | 9394 | 206997_s_at | 0.0043 | 0.9271 | |
| GSE26886 | HS6ST1 | 9394 | 225263_at | 0.4672 | 0.1639 | |
| GSE29001 | HS6ST1 | 9394 | 206997_s_at | -0.0606 | 0.6572 | |
| GSE38129 | HS6ST1 | 9394 | 206997_s_at | -0.0974 | 0.5676 | |
| GSE45670 | HS6ST1 | 9394 | 225263_at | 0.5734 | 0.0000 | |
| GSE53622 | HS6ST1 | 9394 | 134937 | 0.2350 | 0.0122 | |
| GSE53624 | HS6ST1 | 9394 | 134937 | 0.2938 | 0.0000 | |
| GSE63941 | HS6ST1 | 9394 | 225263_at | -0.2850 | 0.5163 | |
| GSE77861 | HS6ST1 | 9394 | 225263_at | 0.2161 | 0.3148 | |
| GSE97050 | HS6ST1 | 9394 | A_24_P8220 | 0.1729 | 0.6268 | |
| SRP007169 | HS6ST1 | 9394 | RNAseq | 1.0648 | 0.0670 | |
| SRP008496 | HS6ST1 | 9394 | RNAseq | 0.9034 | 0.0103 | |
| SRP064894 | HS6ST1 | 9394 | RNAseq | 0.1180 | 0.4825 | |
| SRP133303 | HS6ST1 | 9394 | RNAseq | 0.2758 | 0.2080 | |
| SRP159526 | HS6ST1 | 9394 | RNAseq | 1.0067 | 0.0023 | |
| SRP193095 | HS6ST1 | 9394 | RNAseq | 0.2887 | 0.1849 | |
| SRP219564 | HS6ST1 | 9394 | RNAseq | -0.0777 | 0.8555 | |
| TCGA | HS6ST1 | 9394 | RNAseq | 0.3060 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HS6ST1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HS6ST1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HS6ST1 | 9394 | 6 | 3 | 21 | |
| GSE20123 | HS6ST1 | 9394 | 6 | 3 | 21 | |
| GSE43470 | HS6ST1 | 9394 | 2 | 1 | 40 | |
| GSE46452 | HS6ST1 | 9394 | 1 | 3 | 55 | |
| GSE47630 | HS6ST1 | 9394 | 6 | 0 | 34 | |
| GSE54993 | HS6ST1 | 9394 | 0 | 6 | 64 | |
| GSE54994 | HS6ST1 | 9394 | 11 | 0 | 42 | |
| GSE60625 | HS6ST1 | 9394 | 0 | 3 | 8 | |
| GSE74703 | HS6ST1 | 9394 | 2 | 1 | 33 | |
| GSE74704 | HS6ST1 | 9394 | 3 | 1 | 16 | |
| TCGA | HS6ST1 | 9394 | 22 | 8 | 66 |
Total number of gains: 59; Total number of losses: 29; Total Number of normals: 400.
Somatic mutations of HS6ST1:
Generating mutation plots.
Highly correlated genes for HS6ST1:
Showing top 20/487 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HS6ST1 | ZNF680 | 0.790369 | 3 | 0 | 3 |
| HS6ST1 | OPLAH | 0.763658 | 3 | 0 | 3 |
| HS6ST1 | ARMC8 | 0.753501 | 3 | 0 | 3 |
| HS6ST1 | TMTC4 | 0.747192 | 4 | 0 | 4 |
| HS6ST1 | NUDCD1 | 0.743999 | 3 | 0 | 3 |
| HS6ST1 | XPNPEP3 | 0.742761 | 4 | 0 | 4 |
| HS6ST1 | ZAP70 | 0.73941 | 3 | 0 | 3 |
| HS6ST1 | ACVR1C | 0.738912 | 3 | 0 | 3 |
| HS6ST1 | NCOA6 | 0.736181 | 3 | 0 | 3 |
| HS6ST1 | C8A | 0.731235 | 3 | 0 | 3 |
| HS6ST1 | P2RX6 | 0.731185 | 3 | 0 | 3 |
| HS6ST1 | ZC3H3 | 0.727616 | 3 | 0 | 3 |
| HS6ST1 | KSR1 | 0.723427 | 3 | 0 | 3 |
| HS6ST1 | NACC1 | 0.720694 | 3 | 0 | 3 |
| HS6ST1 | IER3IP1 | 0.720141 | 3 | 0 | 3 |
| HS6ST1 | SLC22A5 | 0.718169 | 3 | 0 | 3 |
| HS6ST1 | SSBP4 | 0.715054 | 3 | 0 | 3 |
| HS6ST1 | SLC5A3 | 0.713953 | 3 | 0 | 3 |
| HS6ST1 | KNOP1 | 0.711061 | 3 | 0 | 3 |
| HS6ST1 | C10orf95 | 0.708966 | 4 | 0 | 4 |
For details and further investigation, click here
