| Full name: MAP kinase activating death domain | Alias Symbol: DENN|KIAA0358|RAB3GEP | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 8567 | HGNC ID: HGNC:6766 | Ensembl Gene: ENSG00000110514 | OMIM ID: 603584 |
| Drug and gene relationship at DGIdb | |||
Expression of MADD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MADD | 8567 | 38398_at | 0.1751 | 0.4903 | |
| GSE20347 | MADD | 8567 | 210252_s_at | 0.0352 | 0.7291 | |
| GSE23400 | MADD | 8567 | 38398_at | 0.0135 | 0.5904 | |
| GSE26886 | MADD | 8567 | 210252_s_at | 0.4442 | 0.0121 | |
| GSE29001 | MADD | 8567 | 38398_at | 0.0254 | 0.9103 | |
| GSE38129 | MADD | 8567 | 210252_s_at | -0.0463 | 0.6491 | |
| GSE45670 | MADD | 8567 | 210252_s_at | 0.0834 | 0.4060 | |
| GSE53622 | MADD | 8567 | 15953 | -0.7603 | 0.0000 | |
| GSE53624 | MADD | 8567 | 15953 | -0.5824 | 0.0000 | |
| GSE63941 | MADD | 8567 | 38398_at | -0.3726 | 0.1692 | |
| GSE77861 | MADD | 8567 | 210252_s_at | 0.0242 | 0.8611 | |
| GSE97050 | MADD | 8567 | A_33_P3300893 | -0.0851 | 0.7635 | |
| SRP007169 | MADD | 8567 | RNAseq | 0.6612 | 0.1798 | |
| SRP008496 | MADD | 8567 | RNAseq | 0.6100 | 0.0608 | |
| SRP064894 | MADD | 8567 | RNAseq | 0.5167 | 0.0000 | |
| SRP133303 | MADD | 8567 | RNAseq | -0.0337 | 0.7627 | |
| SRP159526 | MADD | 8567 | RNAseq | 0.0359 | 0.8550 | |
| SRP193095 | MADD | 8567 | RNAseq | 0.1089 | 0.5099 | |
| SRP219564 | MADD | 8567 | RNAseq | 0.2688 | 0.3309 | |
| TCGA | MADD | 8567 | RNAseq | -0.2011 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MADD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MADD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MADD | 8567 | 3 | 7 | 20 | |
| GSE20123 | MADD | 8567 | 3 | 6 | 21 | |
| GSE43470 | MADD | 8567 | 1 | 4 | 38 | |
| GSE46452 | MADD | 8567 | 8 | 5 | 46 | |
| GSE47630 | MADD | 8567 | 3 | 9 | 28 | |
| GSE54993 | MADD | 8567 | 3 | 0 | 67 | |
| GSE54994 | MADD | 8567 | 1 | 11 | 41 | |
| GSE60625 | MADD | 8567 | 0 | 0 | 11 | |
| GSE74703 | MADD | 8567 | 1 | 2 | 33 | |
| GSE74704 | MADD | 8567 | 2 | 4 | 14 | |
| TCGA | MADD | 8567 | 10 | 20 | 66 |
Total number of gains: 35; Total number of losses: 68; Total Number of normals: 385.
Somatic mutations of MADD:
Generating mutation plots.
Highly correlated genes for MADD:
Showing top 20/375 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MADD | SSBP4 | 0.826583 | 3 | 0 | 3 |
| MADD | CRTC2 | 0.816934 | 3 | 0 | 3 |
| MADD | SLC39A3 | 0.801779 | 3 | 0 | 3 |
| MADD | GRWD1 | 0.773756 | 5 | 0 | 5 |
| MADD | JTB | 0.771284 | 3 | 0 | 3 |
| MADD | ZNF324 | 0.765481 | 3 | 0 | 3 |
| MADD | GATA3 | 0.760741 | 3 | 0 | 3 |
| MADD | SLC35B3 | 0.754366 | 3 | 0 | 3 |
| MADD | NAF1 | 0.745592 | 3 | 0 | 3 |
| MADD | SECTM1 | 0.742405 | 3 | 0 | 3 |
| MADD | ETV6 | 0.742027 | 3 | 0 | 3 |
| MADD | SAMD3 | 0.741934 | 3 | 0 | 3 |
| MADD | SSPN | 0.73776 | 3 | 0 | 3 |
| MADD | CHD3 | 0.729699 | 4 | 0 | 3 |
| MADD | XKR8 | 0.728328 | 3 | 0 | 3 |
| MADD | AAK1 | 0.726169 | 3 | 0 | 3 |
| MADD | STRN4 | 0.721471 | 4 | 0 | 4 |
| MADD | BOLA1 | 0.71937 | 3 | 0 | 3 |
| MADD | RPS19BP1 | 0.718748 | 3 | 0 | 3 |
| MADD | FAM184B | 0.718669 | 3 | 0 | 3 |
For details and further investigation, click here
