| Full name: NPR2 like, GATOR1 complex subunit | Alias Symbol: NPR2L|NPR2 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 10641 | HGNC ID: HGNC:24969 | Ensembl Gene: ENSG00000114388 | OMIM ID: 607072 |
| Drug and gene relationship at DGIdb | |||
NPRL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of NPRL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPRL2 | 10641 | 203246_s_at | 0.0727 | 0.7474 | |
| GSE20347 | NPRL2 | 10641 | 203246_s_at | -0.5596 | 0.0005 | |
| GSE23400 | NPRL2 | 10641 | 203246_s_at | -0.1975 | 0.0009 | |
| GSE26886 | NPRL2 | 10641 | 203246_s_at | -0.4350 | 0.0797 | |
| GSE29001 | NPRL2 | 10641 | 203246_s_at | -0.3911 | 0.1598 | |
| GSE38129 | NPRL2 | 10641 | 203246_s_at | -0.5072 | 0.0000 | |
| GSE45670 | NPRL2 | 10641 | 203246_s_at | -0.3396 | 0.0090 | |
| GSE53622 | NPRL2 | 10641 | 54422 | -0.1958 | 0.0003 | |
| GSE53624 | NPRL2 | 10641 | 54422 | -0.2616 | 0.0000 | |
| GSE63941 | NPRL2 | 10641 | 203246_s_at | 0.0235 | 0.9590 | |
| GSE77861 | NPRL2 | 10641 | 203246_s_at | -0.6449 | 0.0009 | |
| GSE97050 | NPRL2 | 10641 | A_23_P18267 | 0.0053 | 0.9808 | |
| SRP007169 | NPRL2 | 10641 | RNAseq | -1.4326 | 0.0002 | |
| SRP008496 | NPRL2 | 10641 | RNAseq | -1.1063 | 0.0002 | |
| SRP064894 | NPRL2 | 10641 | RNAseq | -0.0733 | 0.7475 | |
| SRP133303 | NPRL2 | 10641 | RNAseq | -0.4799 | 0.0032 | |
| SRP159526 | NPRL2 | 10641 | RNAseq | -0.3485 | 0.1011 | |
| SRP193095 | NPRL2 | 10641 | RNAseq | -0.6934 | 0.0000 | |
| SRP219564 | NPRL2 | 10641 | RNAseq | -0.1489 | 0.7005 | |
| TCGA | NPRL2 | 10641 | RNAseq | -0.2758 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NPRL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPRL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPRL2 | 10641 | 0 | 18 | 12 | |
| GSE20123 | NPRL2 | 10641 | 0 | 19 | 11 | |
| GSE43470 | NPRL2 | 10641 | 0 | 19 | 24 | |
| GSE46452 | NPRL2 | 10641 | 2 | 16 | 41 | |
| GSE47630 | NPRL2 | 10641 | 1 | 24 | 15 | |
| GSE54993 | NPRL2 | 10641 | 6 | 2 | 62 | |
| GSE54994 | NPRL2 | 10641 | 0 | 34 | 19 | |
| GSE60625 | NPRL2 | 10641 | 5 | 0 | 6 | |
| GSE74703 | NPRL2 | 10641 | 0 | 15 | 21 | |
| GSE74704 | NPRL2 | 10641 | 0 | 12 | 8 | |
| TCGA | NPRL2 | 10641 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of NPRL2:
Generating mutation plots.
Highly correlated genes for NPRL2:
Showing top 20/591 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPRL2 | KIAA0513 | 0.829313 | 3 | 0 | 3 |
| NPRL2 | FBXO10 | 0.805568 | 3 | 0 | 3 |
| NPRL2 | ABHD16A | 0.801468 | 4 | 0 | 4 |
| NPRL2 | TYSND1 | 0.789521 | 3 | 0 | 3 |
| NPRL2 | FBXW5 | 0.77999 | 3 | 0 | 3 |
| NPRL2 | ZMYND11 | 0.769915 | 3 | 0 | 3 |
| NPRL2 | KCTD15 | 0.759812 | 3 | 0 | 3 |
| NPRL2 | PARP15 | 0.756266 | 3 | 0 | 3 |
| NPRL2 | MGMT | 0.75554 | 3 | 0 | 3 |
| NPRL2 | SAMD9L | 0.754075 | 3 | 0 | 3 |
| NPRL2 | DUSP22 | 0.75033 | 5 | 0 | 5 |
| NPRL2 | SLC35B3 | 0.743721 | 3 | 0 | 3 |
| NPRL2 | RB1CC1 | 0.743265 | 3 | 0 | 3 |
| NPRL2 | PI4KB | 0.742331 | 3 | 0 | 3 |
| NPRL2 | MBD2 | 0.742002 | 3 | 0 | 3 |
| NPRL2 | PPP2R1B | 0.733879 | 3 | 0 | 3 |
| NPRL2 | CHCHD1 | 0.730716 | 3 | 0 | 3 |
| NPRL2 | UBE2E1 | 0.727443 | 6 | 0 | 5 |
| NPRL2 | NUDT9 | 0.72721 | 3 | 0 | 3 |
| NPRL2 | ZNF784 | 0.727102 | 3 | 0 | 3 |
For details and further investigation, click here
