| Full name: SH3 domain binding kinase 1 | Alias Symbol: Sbk | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 388228 | HGNC ID: HGNC:17699 | Ensembl Gene: ENSG00000188322 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SBK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SBK1 | 388228 | 226548_at | 0.2820 | 0.4281 | |
| GSE26886 | SBK1 | 388228 | 226549_at | 1.0045 | 0.0000 | |
| GSE45670 | SBK1 | 388228 | 226548_at | 0.4560 | 0.1753 | |
| GSE53622 | SBK1 | 388228 | 148059 | 0.5007 | 0.1148 | |
| GSE53624 | SBK1 | 388228 | 148059 | 0.6793 | 0.0022 | |
| GSE63941 | SBK1 | 388228 | 226548_at | 1.2099 | 0.0249 | |
| GSE77861 | SBK1 | 388228 | 226548_at | -0.0173 | 0.9306 | |
| GSE97050 | SBK1 | 388228 | A_33_P3366336 | 0.4260 | 0.1657 | |
| SRP007169 | SBK1 | 388228 | RNAseq | 0.3841 | 0.5260 | |
| SRP008496 | SBK1 | 388228 | RNAseq | 1.0854 | 0.0064 | |
| SRP064894 | SBK1 | 388228 | RNAseq | 0.5649 | 0.1093 | |
| SRP133303 | SBK1 | 388228 | RNAseq | 0.2026 | 0.1620 | |
| SRP159526 | SBK1 | 388228 | RNAseq | 3.1497 | 0.0000 | |
| SRP193095 | SBK1 | 388228 | RNAseq | 0.4844 | 0.0118 | |
| SRP219564 | SBK1 | 388228 | RNAseq | 1.3972 | 0.0426 | |
| TCGA | SBK1 | 388228 | RNAseq | 0.3557 | 0.1830 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SBK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SBK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SBK1 | 388228 | 4 | 5 | 21 | |
| GSE20123 | SBK1 | 388228 | 4 | 4 | 22 | |
| GSE43470 | SBK1 | 388228 | 4 | 3 | 36 | |
| GSE46452 | SBK1 | 388228 | 38 | 1 | 20 | |
| GSE47630 | SBK1 | 388228 | 11 | 7 | 22 | |
| GSE54993 | SBK1 | 388228 | 3 | 5 | 62 | |
| GSE54994 | SBK1 | 388228 | 4 | 9 | 40 | |
| GSE60625 | SBK1 | 388228 | 4 | 0 | 7 | |
| GSE74703 | SBK1 | 388228 | 4 | 2 | 30 | |
| GSE74704 | SBK1 | 388228 | 3 | 2 | 15 | |
| TCGA | SBK1 | 388228 | 20 | 12 | 64 |
Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.
Somatic mutations of SBK1:
Generating mutation plots.
Highly correlated genes for SBK1:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SBK1 | SMARCD2 | 0.764014 | 3 | 0 | 3 |
| SBK1 | NXT1 | 0.72618 | 3 | 0 | 3 |
| SBK1 | TRPM2 | 0.720252 | 3 | 0 | 3 |
| SBK1 | MEA1 | 0.717885 | 3 | 0 | 3 |
| SBK1 | TRIM27 | 0.716434 | 3 | 0 | 3 |
| SBK1 | SNRPC | 0.713678 | 3 | 0 | 3 |
| SBK1 | GATA3 | 0.702807 | 3 | 0 | 3 |
| SBK1 | CRTC2 | 0.70102 | 3 | 0 | 3 |
| SBK1 | MYO9B | 0.689483 | 3 | 0 | 3 |
| SBK1 | CHCHD2 | 0.685804 | 3 | 0 | 3 |
| SBK1 | RRM1 | 0.678887 | 3 | 0 | 3 |
| SBK1 | CCDC24 | 0.675177 | 4 | 0 | 4 |
| SBK1 | PPP5C | 0.673316 | 3 | 0 | 3 |
| SBK1 | DDX56 | 0.670457 | 3 | 0 | 3 |
| SBK1 | TYK2 | 0.668856 | 3 | 0 | 3 |
| SBK1 | TP53I11 | 0.663343 | 3 | 0 | 3 |
| SBK1 | ELF4 | 0.663125 | 3 | 0 | 3 |
| SBK1 | SLC39A3 | 0.65892 | 3 | 0 | 3 |
| SBK1 | TNK1 | 0.658795 | 4 | 0 | 4 |
| SBK1 | PIK3R3 | 0.658481 | 5 | 0 | 5 |
For details and further investigation, click here
