| Full name: centrosomal protein 250 | Alias Symbol: C-NAP1 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 11190 | HGNC ID: HGNC:1859 | Ensembl Gene: ENSG00000126001 | OMIM ID: 609689 |
| Drug and gene relationship at DGIdb | |||
Expression of CEP250:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CEP250 | 11190 | 209495_at | 0.6679 | 0.0481 | |
| GSE20347 | CEP250 | 11190 | 209495_at | 0.3537 | 0.0019 | |
| GSE23400 | CEP250 | 11190 | 209495_at | 0.0656 | 0.0862 | |
| GSE26886 | CEP250 | 11190 | 209495_at | 0.6428 | 0.0002 | |
| GSE29001 | CEP250 | 11190 | 209495_at | 0.3910 | 0.0369 | |
| GSE38129 | CEP250 | 11190 | 209495_at | 0.3246 | 0.0011 | |
| GSE45670 | CEP250 | 11190 | 209495_at | 0.2869 | 0.0121 | |
| GSE53622 | CEP250 | 11190 | 39355 | 0.5619 | 0.0000 | |
| GSE53624 | CEP250 | 11190 | 39355 | 0.3902 | 0.0001 | |
| GSE63941 | CEP250 | 11190 | 209495_at | 0.4622 | 0.2647 | |
| GSE77861 | CEP250 | 11190 | 209495_at | 0.2212 | 0.1288 | |
| GSE97050 | CEP250 | 11190 | A_23_P102832 | 0.3330 | 0.3980 | |
| SRP007169 | CEP250 | 11190 | RNAseq | 1.0459 | 0.0549 | |
| SRP008496 | CEP250 | 11190 | RNAseq | 1.4016 | 0.0004 | |
| SRP064894 | CEP250 | 11190 | RNAseq | 1.0429 | 0.0001 | |
| SRP133303 | CEP250 | 11190 | RNAseq | 0.3720 | 0.0411 | |
| SRP159526 | CEP250 | 11190 | RNAseq | 0.6118 | 0.0611 | |
| SRP193095 | CEP250 | 11190 | RNAseq | 0.4613 | 0.0012 | |
| SRP219564 | CEP250 | 11190 | RNAseq | 0.7802 | 0.0088 | |
| TCGA | CEP250 | 11190 | RNAseq | 0.2071 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CEP250 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CEP250:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CEP250 | 11190 | 15 | 1 | 14 | |
| GSE20123 | CEP250 | 11190 | 15 | 1 | 14 | |
| GSE43470 | CEP250 | 11190 | 13 | 0 | 30 | |
| GSE46452 | CEP250 | 11190 | 29 | 0 | 30 | |
| GSE47630 | CEP250 | 11190 | 25 | 0 | 15 | |
| GSE54993 | CEP250 | 11190 | 0 | 17 | 53 | |
| GSE54994 | CEP250 | 11190 | 24 | 0 | 29 | |
| GSE60625 | CEP250 | 11190 | 0 | 0 | 11 | |
| GSE74703 | CEP250 | 11190 | 11 | 0 | 25 | |
| GSE74704 | CEP250 | 11190 | 11 | 0 | 9 | |
| TCGA | CEP250 | 11190 | 49 | 3 | 44 |
Total number of gains: 192; Total number of losses: 22; Total Number of normals: 274.
Somatic mutations of CEP250:
Generating mutation plots.
Highly correlated genes for CEP250:
Showing top 20/1030 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CEP250 | ASPH | 0.793411 | 3 | 0 | 3 |
| CEP250 | SPIC | 0.773391 | 3 | 0 | 3 |
| CEP250 | LINC01116 | 0.772102 | 3 | 0 | 3 |
| CEP250 | DERL1 | 0.752736 | 3 | 0 | 3 |
| CEP250 | ZC3HC1 | 0.741188 | 3 | 0 | 3 |
| CEP250 | CNIH3 | 0.738485 | 3 | 0 | 3 |
| CEP250 | SLC41A1 | 0.733991 | 4 | 0 | 3 |
| CEP250 | HOXD8 | 0.733655 | 4 | 0 | 3 |
| CEP250 | SMYD2 | 0.731099 | 3 | 0 | 3 |
| CEP250 | SURF6 | 0.730971 | 3 | 0 | 3 |
| CEP250 | GALNT2 | 0.730626 | 4 | 0 | 3 |
| CEP250 | DDX18 | 0.730506 | 4 | 0 | 4 |
| CEP250 | SFR1 | 0.729996 | 4 | 0 | 3 |
| CEP250 | MRPL14 | 0.728475 | 3 | 0 | 3 |
| CEP250 | CTU2 | 0.725603 | 4 | 0 | 4 |
| CEP250 | CPSF6 | 0.721315 | 4 | 0 | 3 |
| CEP250 | PHC2 | 0.720666 | 3 | 0 | 3 |
| CEP250 | REC8 | 0.720608 | 4 | 0 | 4 |
| CEP250 | MRPL52 | 0.720472 | 3 | 0 | 3 |
| CEP250 | STAT2 | 0.720062 | 3 | 0 | 3 |
For details and further investigation, click here
