KDM5A

 

Full name: lysine demethylase 5A Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.33
Entrez ID: 5927 HGNC ID: HGNC:9886 Ensembl Gene: ENSG00000073614 OMIM ID: 180202
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KDM5A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KDM5A 5927 202040_s_at -0.0895 0.7709
GSE20347 KDM5A 5927 202040_s_at 0.1105 0.6044
GSE23400 KDM5A 5927 202040_s_at 0.2961 0.0017
GSE26886 KDM5A 5927 202040_s_at 0.9593 0.0035
GSE29001 KDM5A 5927 202040_s_at 0.2593 0.4285
GSE38129 KDM5A 5927 202040_s_at 0.1202 0.5295
GSE45670 KDM5A 5927 202040_s_at 0.3787 0.0261
GSE63941 KDM5A 5927 202040_s_at 0.0675 0.8740
GSE77861 KDM5A 5927 202040_s_at 0.8098 0.0326
GSE97050 KDM5A 5927 A_33_P3382748 0.1274 0.6715
SRP007169 KDM5A 5927 RNAseq 0.9083 0.0730
SRP008496 KDM5A 5927 RNAseq 0.9705 0.0018
SRP064894 KDM5A 5927 RNAseq -0.1768 0.2427
SRP133303 KDM5A 5927 RNAseq 0.3926 0.0781
SRP159526 KDM5A 5927 RNAseq 0.1243 0.5610
SRP193095 KDM5A 5927 RNAseq 0.0924 0.2644
SRP219564 KDM5A 5927 RNAseq -0.1352 0.6456
TCGA KDM5A 5927 RNAseq 0.0511 0.2726

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KDM5A expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of KDM5A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KDM5A 5927 7 4 19
GSE20123 KDM5A 5927 7 4 19
GSE43470 KDM5A 5927 8 3 32
GSE46452 KDM5A 5927 10 1 48
GSE47630 KDM5A 5927 12 2 26
GSE54993 KDM5A 5927 1 10 59
GSE54994 KDM5A 5927 10 2 41
GSE60625 KDM5A 5927 0 1 10
GSE74703 KDM5A 5927 7 2 27
GSE74704 KDM5A 5927 4 2 14
TCGA KDM5A 5927 41 7 48

Total number of gains: 107; Total number of losses: 38; Total Number of normals: 343.  

 

Somatic mutations of KDM5A:

 

Generating mutation plots.

 

Highly correlated genes for KDM5A:

 

Showing top 20/309 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KDM5AACBD60.793454303
KDM5ARIMKLB0.77321404
KDM5ANUDT110.767876303
KDM5ASENP10.765787303
KDM5ACEP950.757894303
KDM5ALIN90.75248303
KDM5APPHLN10.75003303
KDM5AC1orf1310.744016303
KDM5ANAB20.738745303
KDM5ANAPEPLD0.732825303
KDM5AATP11C0.728476303
KDM5ACHD80.727845303
KDM5APRR5L0.726865303
KDM5AMED170.726703303
KDM5ACENPV0.725328303
KDM5AGAL0.720549303
KDM5AAKAP8L0.71358303
KDM5ALOXL40.711952303
KDM5AMAGOHB0.708676504
KDM5ARP90.706757303

For details and further investigation, click here