GNG11

 

Full name: G protein subunit gamma 11 Alias Symbol: GNGT11
Type: protein-coding gene Cytoband: 7q21.3
Entrez ID: 2791 HGNC ID: HGNC:4403 Ensembl Gene: ENSG00000127920 OMIM ID: 604390
Drug and gene relationship at DGIdb

 

GNG11 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG11 2791 204115_at -1.0793 0.1241
GSE20347 GNG11 2791 204115_at -0.6244 0.0006
GSE23400 GNG11 2791 204115_at -0.3808 0.0070
GSE26886 GNG11 2791 204115_at 0.5293 0.1340
GSE29001 GNG11 2791 204115_at -0.5738 0.2002
GSE38129 GNG11 2791 204115_at -1.0251 0.0182
GSE45670 GNG11 2791 204115_at -1.5173 0.0009
GSE53622 GNG11 2791 77269 -1.0207 0.0000
GSE53624 GNG11 2791 77269 -0.6876 0.0000
GSE63941 GNG11 2791 204115_at -7.9457 0.0000
GSE77861 GNG11 2791 204115_at 0.5405 0.0757
GSE97050 GNG11 2791 A_23_P111701 -0.5267 0.1604
SRP007169 GNG11 2791 RNAseq 0.3913 0.3128
SRP008496 GNG11 2791 RNAseq 1.1286 0.0019
SRP064894 GNG11 2791 RNAseq 0.0710 0.8552
SRP133303 GNG11 2791 RNAseq -0.8635 0.0047
SRP159526 GNG11 2791 RNAseq -0.3836 0.3605
SRP193095 GNG11 2791 RNAseq 0.3573 0.1622
SRP219564 GNG11 2791 RNAseq -0.3937 0.5870
TCGA GNG11 2791 RNAseq -0.4293 0.0001

Upregulated datasets: 1; Downregulated datasets: 4.  

 

Survival by GNG11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG11 2791 13 0 17
GSE20123 GNG11 2791 13 0 17
GSE43470 GNG11 2791 7 1 35
GSE46452 GNG11 2791 12 0 47
GSE47630 GNG11 2791 9 2 29
GSE54993 GNG11 2791 1 9 60
GSE54994 GNG11 2791 16 2 35
GSE60625 GNG11 2791 0 5 6
GSE74703 GNG11 2791 6 1 29
GSE74704 GNG11 2791 9 0 11
TCGA GNG11 2791 56 4 36

Total number of gains: 142; Total number of losses: 24; Total Number of normals: 322.  

 

Somatic mutations of GNG11:

 

Generating mutation plots.

 

Highly correlated genes for GNG11:

 

Showing top 20/1178 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG11CNRIP10.82365908
GNG11ECSCR0.814884707
GNG11CLEC3B0.811782303
GNG11MAGI2-AS30.810726606
GNG11FIBIN0.809739505
GNG11ARHGAP60.80624210010
GNG11ZNF5830.802297303
GNG11MRVI10.794619707
GNG11LRRN4CL0.789512808
GNG11FGF70.787521808
GNG11MIER10.78675303
GNG11EBF30.7841606
GNG11CD930.77936311011
GNG11JAM30.77392113012
GNG11KPNA60.770886303
GNG11ZCCHC240.76856411011
GNG11C11orf960.768495505
GNG11ST6GALNAC30.765298606
GNG11UBXN100.764707404
GNG11ANXA60.7643221009

For details and further investigation, click here