| Full name: karyopherin subunit alpha 6 | Alias Symbol: IPOA7|KPNA7|MGC17918|FLJ11249 | ||
| Type: protein-coding gene | Cytoband: 1p35.2 | ||
| Entrez ID: 23633 | HGNC ID: HGNC:6399 | Ensembl Gene: ENSG00000025800 | OMIM ID: 610563 |
| Drug and gene relationship at DGIdb | |||
Expression of KPNA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA6 | 23633 | 212101_at | 0.2451 | 0.3827 | |
| GSE20347 | KPNA6 | 23633 | 212103_at | -0.1561 | 0.1708 | |
| GSE23400 | KPNA6 | 23633 | 212101_at | -0.0060 | 0.9134 | |
| GSE26886 | KPNA6 | 23633 | 212101_at | -0.4209 | 0.0276 | |
| GSE29001 | KPNA6 | 23633 | 212101_at | -0.1160 | 0.6276 | |
| GSE38129 | KPNA6 | 23633 | 212101_at | -0.0822 | 0.5397 | |
| GSE45670 | KPNA6 | 23633 | 226976_at | 0.0576 | 0.6988 | |
| GSE53622 | KPNA6 | 23633 | 22992 | -0.1426 | 0.0076 | |
| GSE53624 | KPNA6 | 23633 | 22992 | -0.0478 | 0.3443 | |
| GSE63941 | KPNA6 | 23633 | 226976_at | -1.8045 | 0.0010 | |
| GSE77861 | KPNA6 | 23633 | 212101_at | 0.0504 | 0.8364 | |
| GSE97050 | KPNA6 | 23633 | A_33_P3214874 | -0.3271 | 0.2292 | |
| SRP007169 | KPNA6 | 23633 | RNAseq | 0.2734 | 0.5453 | |
| SRP008496 | KPNA6 | 23633 | RNAseq | 0.2225 | 0.3887 | |
| SRP064894 | KPNA6 | 23633 | RNAseq | 0.1044 | 0.3822 | |
| SRP133303 | KPNA6 | 23633 | RNAseq | 0.1243 | 0.3953 | |
| SRP159526 | KPNA6 | 23633 | RNAseq | -0.1501 | 0.4194 | |
| SRP193095 | KPNA6 | 23633 | RNAseq | -0.0708 | 0.4066 | |
| SRP219564 | KPNA6 | 23633 | RNAseq | -0.3822 | 0.0887 | |
| TCGA | KPNA6 | 23633 | RNAseq | -0.0319 | 0.4435 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KPNA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA6 | 23633 | 1 | 5 | 24 | |
| GSE20123 | KPNA6 | 23633 | 1 | 4 | 25 | |
| GSE43470 | KPNA6 | 23633 | 6 | 4 | 33 | |
| GSE46452 | KPNA6 | 23633 | 5 | 1 | 53 | |
| GSE47630 | KPNA6 | 23633 | 8 | 3 | 29 | |
| GSE54993 | KPNA6 | 23633 | 1 | 1 | 68 | |
| GSE54994 | KPNA6 | 23633 | 11 | 2 | 40 | |
| GSE60625 | KPNA6 | 23633 | 0 | 0 | 11 | |
| GSE74703 | KPNA6 | 23633 | 4 | 3 | 29 | |
| GSE74704 | KPNA6 | 23633 | 0 | 0 | 20 | |
| TCGA | KPNA6 | 23633 | 12 | 20 | 64 |
Total number of gains: 49; Total number of losses: 43; Total Number of normals: 396.
Somatic mutations of KPNA6:
Generating mutation plots.
Highly correlated genes for KPNA6:
Showing top 20/343 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA6 | CLMP | 0.784703 | 3 | 0 | 3 |
| KPNA6 | TCF21 | 0.783635 | 3 | 0 | 3 |
| KPNA6 | RFTN1 | 0.777499 | 3 | 0 | 3 |
| KPNA6 | GNG11 | 0.770886 | 3 | 0 | 3 |
| KPNA6 | USF1 | 0.764245 | 3 | 0 | 3 |
| KPNA6 | RAB7A | 0.746363 | 4 | 0 | 4 |
| KPNA6 | USP37 | 0.744313 | 3 | 0 | 3 |
| KPNA6 | LTBP2 | 0.740103 | 3 | 0 | 3 |
| KPNA6 | CSRNP2 | 0.737288 | 3 | 0 | 3 |
| KPNA6 | CYP27A1 | 0.734956 | 3 | 0 | 3 |
| KPNA6 | ZNF844 | 0.727808 | 3 | 0 | 3 |
| KPNA6 | TMEM129 | 0.725685 | 3 | 0 | 3 |
| KPNA6 | ABL1 | 0.725031 | 3 | 0 | 3 |
| KPNA6 | ZNF578 | 0.720141 | 3 | 0 | 3 |
| KPNA6 | TK2 | 0.715942 | 4 | 0 | 4 |
| KPNA6 | CD63 | 0.714023 | 3 | 0 | 3 |
| KPNA6 | PRR16 | 0.709427 | 3 | 0 | 3 |
| KPNA6 | HGF | 0.708849 | 3 | 0 | 3 |
| KPNA6 | TGM2 | 0.706536 | 3 | 0 | 3 |
| KPNA6 | ABCA8 | 0.700328 | 3 | 0 | 3 |
For details and further investigation, click here
