| Full name: murine retrovirus integration site 1 homolog | Alias Symbol: JAW1L|IRAG | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 10335 | HGNC ID: HGNC:7237 | Ensembl Gene: ENSG00000072952 | OMIM ID: 604673 |
| Drug and gene relationship at DGIdb | |||
MRVI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of MRVI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRVI1 | 10335 | 226047_at | -1.5767 | 0.1194 | |
| GSE26886 | MRVI1 | 10335 | 226047_at | 0.3055 | 0.4896 | |
| GSE45670 | MRVI1 | 10335 | 226047_at | -2.3410 | 0.0000 | |
| GSE53622 | MRVI1 | 10335 | 81321 | -1.6057 | 0.0000 | |
| GSE53624 | MRVI1 | 10335 | 81321 | -1.4500 | 0.0000 | |
| GSE63941 | MRVI1 | 10335 | 226047_at | -5.3859 | 0.0000 | |
| GSE77861 | MRVI1 | 10335 | 226047_at | 0.0656 | 0.8654 | |
| GSE97050 | MRVI1 | 10335 | A_33_P3311403 | -1.2247 | 0.0786 | |
| SRP007169 | MRVI1 | 10335 | RNAseq | -0.0064 | 0.9873 | |
| SRP008496 | MRVI1 | 10335 | RNAseq | 0.6543 | 0.0644 | |
| SRP064894 | MRVI1 | 10335 | RNAseq | -0.2465 | 0.5347 | |
| SRP133303 | MRVI1 | 10335 | RNAseq | -0.6133 | 0.2190 | |
| SRP159526 | MRVI1 | 10335 | RNAseq | -0.9224 | 0.1382 | |
| SRP193095 | MRVI1 | 10335 | RNAseq | 0.2180 | 0.4338 | |
| SRP219564 | MRVI1 | 10335 | RNAseq | -0.5466 | 0.5997 | |
| TCGA | MRVI1 | 10335 | RNAseq | -0.6460 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MRVI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRVI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRVI1 | 10335 | 0 | 9 | 21 | |
| GSE20123 | MRVI1 | 10335 | 0 | 10 | 20 | |
| GSE43470 | MRVI1 | 10335 | 1 | 6 | 36 | |
| GSE46452 | MRVI1 | 10335 | 7 | 5 | 47 | |
| GSE47630 | MRVI1 | 10335 | 3 | 11 | 26 | |
| GSE54993 | MRVI1 | 10335 | 3 | 1 | 66 | |
| GSE54994 | MRVI1 | 10335 | 4 | 12 | 37 | |
| GSE60625 | MRVI1 | 10335 | 0 | 0 | 11 | |
| GSE74703 | MRVI1 | 10335 | 1 | 4 | 31 | |
| GSE74704 | MRVI1 | 10335 | 0 | 7 | 13 | |
| TCGA | MRVI1 | 10335 | 11 | 34 | 51 |
Total number of gains: 30; Total number of losses: 99; Total Number of normals: 359.
Somatic mutations of MRVI1:
Generating mutation plots.
Highly correlated genes for MRVI1:
Showing top 20/1296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRVI1 | AFF3 | 0.92213 | 3 | 0 | 3 |
| MRVI1 | NEGR1 | 0.888629 | 6 | 0 | 6 |
| MRVI1 | PDE5A | 0.88304 | 7 | 0 | 7 |
| MRVI1 | ASPA | 0.88119 | 6 | 0 | 6 |
| MRVI1 | FENDRR | 0.879926 | 5 | 0 | 5 |
| MRVI1 | SLITRK3 | 0.87462 | 5 | 0 | 5 |
| MRVI1 | ACTG2 | 0.867968 | 8 | 0 | 8 |
| MRVI1 | NEXN | 0.867516 | 8 | 0 | 8 |
| MRVI1 | UBXN10 | 0.866089 | 3 | 0 | 3 |
| MRVI1 | CCDC69 | 0.865426 | 6 | 0 | 6 |
| MRVI1 | LMOD1 | 0.864937 | 8 | 0 | 8 |
| MRVI1 | SORCS1 | 0.861754 | 4 | 0 | 4 |
| MRVI1 | INMT | 0.861491 | 7 | 0 | 7 |
| MRVI1 | RCAN2 | 0.859832 | 8 | 0 | 8 |
| MRVI1 | CHRDL1 | 0.852227 | 5 | 0 | 5 |
| MRVI1 | HSPB6 | 0.851966 | 5 | 0 | 5 |
| MRVI1 | CYP21A2 | 0.84584 | 3 | 0 | 3 |
| MRVI1 | MRGPRF | 0.845008 | 7 | 0 | 7 |
| MRVI1 | BHMT2 | 0.840646 | 7 | 0 | 6 |
| MRVI1 | CLIP3 | 0.840527 | 7 | 0 | 7 |
For details and further investigation, click here
