| Full name: G protein subunit gamma 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q22.1 | ||
| Entrez ID: 54331 | HGNC ID: HGNC:4404 | Ensembl Gene: ENSG00000186469 | OMIM ID: 606981 |
| Drug and gene relationship at DGIdb | |||
GNG2 involved pathways:
Expression of GNG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNG2 | 54331 | 224964_s_at | -0.7682 | 0.3313 | |
| GSE26886 | GNG2 | 54331 | 224964_s_at | -0.7254 | 0.1067 | |
| GSE45670 | GNG2 | 54331 | 224964_s_at | -1.7007 | 0.0003 | |
| GSE53622 | GNG2 | 54331 | 52981 | -0.2988 | 0.0011 | |
| GSE53624 | GNG2 | 54331 | 52981 | -0.2115 | 0.0046 | |
| GSE63941 | GNG2 | 54331 | 224964_s_at | -4.6564 | 0.0003 | |
| GSE77861 | GNG2 | 54331 | 223943_s_at | -0.0217 | 0.8609 | |
| GSE97050 | GNG2 | 54331 | A_32_P208403 | -0.1224 | 0.6209 | |
| SRP007169 | GNG2 | 54331 | RNAseq | 0.4288 | 0.4014 | |
| SRP008496 | GNG2 | 54331 | RNAseq | 0.5513 | 0.1314 | |
| SRP064894 | GNG2 | 54331 | RNAseq | 0.0352 | 0.8917 | |
| SRP133303 | GNG2 | 54331 | RNAseq | -0.2775 | 0.2412 | |
| SRP159526 | GNG2 | 54331 | RNAseq | -0.1474 | 0.7467 | |
| SRP193095 | GNG2 | 54331 | RNAseq | 0.2043 | 0.3940 | |
| SRP219564 | GNG2 | 54331 | RNAseq | 0.0880 | 0.8720 | |
| TCGA | GNG2 | 54331 | RNAseq | -0.2279 | 0.0517 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GNG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNG2 | 54331 | 8 | 4 | 18 | |
| GSE20123 | GNG2 | 54331 | 8 | 4 | 18 | |
| GSE43470 | GNG2 | 54331 | 9 | 1 | 33 | |
| GSE46452 | GNG2 | 54331 | 16 | 3 | 40 | |
| GSE47630 | GNG2 | 54331 | 11 | 10 | 19 | |
| GSE54993 | GNG2 | 54331 | 3 | 8 | 59 | |
| GSE54994 | GNG2 | 54331 | 19 | 4 | 30 | |
| GSE60625 | GNG2 | 54331 | 0 | 2 | 9 | |
| GSE74703 | GNG2 | 54331 | 8 | 1 | 27 | |
| GSE74704 | GNG2 | 54331 | 3 | 3 | 14 | |
| TCGA | GNG2 | 54331 | 34 | 12 | 50 |
Total number of gains: 119; Total number of losses: 52; Total Number of normals: 317.
Somatic mutations of GNG2:
Generating mutation plots.
Highly correlated genes for GNG2:
Showing top 20/790 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNG2 | FBN1 | 0.825187 | 4 | 0 | 4 |
| GNG2 | CNRIP1 | 0.817446 | 5 | 0 | 5 |
| GNG2 | ANXA6 | 0.814443 | 5 | 0 | 5 |
| GNG2 | RHOJ | 0.81416 | 3 | 0 | 3 |
| GNG2 | FBLN5 | 0.80979 | 5 | 0 | 5 |
| GNG2 | DCHS1 | 0.804849 | 4 | 0 | 4 |
| GNG2 | FIBIN | 0.796241 | 4 | 0 | 4 |
| GNG2 | CCDC102B | 0.79268 | 3 | 0 | 3 |
| GNG2 | AFF3 | 0.789873 | 4 | 0 | 4 |
| GNG2 | SLC16A4 | 0.789218 | 5 | 0 | 5 |
| GNG2 | OLFML1 | 0.787071 | 5 | 0 | 5 |
| GNG2 | SMPD1 | 0.784649 | 3 | 0 | 3 |
| GNG2 | OLFML3 | 0.778812 | 5 | 0 | 5 |
| GNG2 | WDR1 | 0.778007 | 3 | 0 | 3 |
| GNG2 | EPHA3 | 0.775736 | 4 | 0 | 4 |
| GNG2 | ST3GAL2 | 0.775523 | 3 | 0 | 3 |
| GNG2 | ZNF583 | 0.773588 | 3 | 0 | 3 |
| GNG2 | LRRN4CL | 0.772233 | 5 | 0 | 5 |
| GNG2 | PMP22 | 0.770071 | 6 | 0 | 5 |
| GNG2 | MAGI2-AS3 | 0.767935 | 4 | 0 | 4 |
For details and further investigation, click here
