| Full name: peripheral myelin protein 22 | Alias Symbol: HNPP|GAS3|Sp110|HMSNIA | ||
| Type: protein-coding gene | Cytoband: 17p12 | ||
| Entrez ID: 5376 | HGNC ID: HGNC:9118 | Ensembl Gene: ENSG00000109099 | OMIM ID: 601097 |
| Drug and gene relationship at DGIdb | |||
Expression of PMP22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PMP22 | 5376 | 210139_s_at | -1.0020 | 0.3366 | |
| GSE20347 | PMP22 | 5376 | 210139_s_at | 0.7349 | 0.0257 | |
| GSE23400 | PMP22 | 5376 | 210139_s_at | -0.0387 | 0.8416 | |
| GSE26886 | PMP22 | 5376 | 210139_s_at | 2.3877 | 0.0003 | |
| GSE29001 | PMP22 | 5376 | 210139_s_at | 0.4931 | 0.2582 | |
| GSE38129 | PMP22 | 5376 | 210139_s_at | 0.1224 | 0.8072 | |
| GSE45670 | PMP22 | 5376 | 210139_s_at | -2.0200 | 0.0001 | |
| GSE53622 | PMP22 | 5376 | 1657 | -0.2400 | 0.0988 | |
| GSE53624 | PMP22 | 5376 | 1657 | 0.0662 | 0.6215 | |
| GSE63941 | PMP22 | 5376 | 210139_s_at | -5.2379 | 0.0008 | |
| GSE77861 | PMP22 | 5376 | 1565639_a_at | 0.0912 | 0.4071 | |
| GSE97050 | PMP22 | 5376 | A_23_P100711 | -0.2099 | 0.4376 | |
| SRP007169 | PMP22 | 5376 | RNAseq | 2.0976 | 0.0003 | |
| SRP008496 | PMP22 | 5376 | RNAseq | 2.2743 | 0.0000 | |
| SRP064894 | PMP22 | 5376 | RNAseq | 0.5068 | 0.1393 | |
| SRP133303 | PMP22 | 5376 | RNAseq | 0.2703 | 0.4155 | |
| SRP159526 | PMP22 | 5376 | RNAseq | 0.3035 | 0.1169 | |
| SRP193095 | PMP22 | 5376 | RNAseq | 0.7693 | 0.0630 | |
| SRP219564 | PMP22 | 5376 | RNAseq | 0.2097 | 0.7703 | |
| TCGA | PMP22 | 5376 | RNAseq | -0.2329 | 0.0155 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by PMP22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PMP22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PMP22 | 5376 | 3 | 3 | 24 | |
| GSE20123 | PMP22 | 5376 | 3 | 4 | 23 | |
| GSE43470 | PMP22 | 5376 | 2 | 4 | 37 | |
| GSE46452 | PMP22 | 5376 | 34 | 1 | 24 | |
| GSE47630 | PMP22 | 5376 | 7 | 1 | 32 | |
| GSE54993 | PMP22 | 5376 | 3 | 3 | 64 | |
| GSE54994 | PMP22 | 5376 | 6 | 5 | 42 | |
| GSE60625 | PMP22 | 5376 | 4 | 0 | 7 | |
| GSE74703 | PMP22 | 5376 | 2 | 2 | 32 | |
| GSE74704 | PMP22 | 5376 | 2 | 2 | 16 | |
| TCGA | PMP22 | 5376 | 18 | 22 | 56 |
Total number of gains: 84; Total number of losses: 47; Total Number of normals: 357.
Somatic mutations of PMP22:
Generating mutation plots.
Highly correlated genes for PMP22:
Showing top 20/1277 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PMP22 | FBN1 | 0.858766 | 10 | 0 | 10 |
| PMP22 | C11orf96 | 0.857933 | 5 | 0 | 5 |
| PMP22 | FERMT2 | 0.825213 | 12 | 0 | 12 |
| PMP22 | FIBIN | 0.822353 | 5 | 0 | 5 |
| PMP22 | OLFML3 | 0.798563 | 12 | 0 | 12 |
| PMP22 | MSRB3 | 0.793067 | 7 | 0 | 7 |
| PMP22 | CALD1 | 0.791952 | 12 | 0 | 12 |
| PMP22 | CNRIP1 | 0.788083 | 9 | 0 | 8 |
| PMP22 | FILIP1L | 0.776837 | 13 | 0 | 12 |
| PMP22 | DCN | 0.775798 | 11 | 0 | 11 |
| PMP22 | ZEB1 | 0.774204 | 3 | 0 | 3 |
| PMP22 | DCHS1 | 0.773831 | 10 | 0 | 9 |
| PMP22 | COLEC12 | 0.773706 | 12 | 0 | 12 |
| PMP22 | LINC01279 | 0.772749 | 4 | 0 | 4 |
| PMP22 | CRISPLD2 | 0.772091 | 13 | 0 | 12 |
| PMP22 | GNG2 | 0.770071 | 6 | 0 | 5 |
| PMP22 | MRGPRF | 0.767984 | 8 | 0 | 8 |
| PMP22 | OLFML1 | 0.76601 | 12 | 0 | 12 |
| PMP22 | MSI2 | 0.765422 | 3 | 0 | 3 |
| PMP22 | DAB2 | 0.765371 | 12 | 0 | 11 |
For details and further investigation, click here
