| Full name: WD repeat domain 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 9948 | HGNC ID: HGNC:12754 | Ensembl Gene: ENSG00000071127 | OMIM ID: 604734 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR1 | 9948 | 200611_s_at | 0.1213 | 0.6726 | |
| GSE20347 | WDR1 | 9948 | 200609_s_at | -0.6314 | 0.0000 | |
| GSE23400 | WDR1 | 9948 | 200611_s_at | -0.1497 | 0.0175 | |
| GSE26886 | WDR1 | 9948 | 200609_s_at | -0.4933 | 0.0013 | |
| GSE29001 | WDR1 | 9948 | 200609_s_at | -0.3187 | 0.1086 | |
| GSE38129 | WDR1 | 9948 | 200609_s_at | -0.5447 | 0.0001 | |
| GSE45670 | WDR1 | 9948 | 200609_s_at | -0.4220 | 0.0016 | |
| GSE53622 | WDR1 | 9948 | 81998 | -0.2421 | 0.0000 | |
| GSE53624 | WDR1 | 9948 | 112711 | -0.3465 | 0.0000 | |
| GSE63941 | WDR1 | 9948 | 200609_s_at | -0.8909 | 0.0292 | |
| GSE77861 | WDR1 | 9948 | 200609_s_at | -0.3233 | 0.0966 | |
| GSE97050 | WDR1 | 9948 | A_33_P3360426 | -0.3608 | 0.1889 | |
| SRP007169 | WDR1 | 9948 | RNAseq | -0.7512 | 0.0399 | |
| SRP008496 | WDR1 | 9948 | RNAseq | -0.6411 | 0.0022 | |
| SRP064894 | WDR1 | 9948 | RNAseq | -0.2208 | 0.1337 | |
| SRP133303 | WDR1 | 9948 | RNAseq | -0.0660 | 0.6772 | |
| SRP159526 | WDR1 | 9948 | RNAseq | -0.2908 | 0.2867 | |
| SRP193095 | WDR1 | 9948 | RNAseq | -0.2652 | 0.0283 | |
| SRP219564 | WDR1 | 9948 | RNAseq | -0.2767 | 0.4696 | |
| TCGA | WDR1 | 9948 | RNAseq | -0.0916 | 0.0249 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WDR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR1 | 9948 | 0 | 19 | 11 | |
| GSE20123 | WDR1 | 9948 | 0 | 19 | 11 | |
| GSE43470 | WDR1 | 9948 | 1 | 15 | 27 | |
| GSE46452 | WDR1 | 9948 | 1 | 36 | 22 | |
| GSE47630 | WDR1 | 9948 | 1 | 19 | 20 | |
| GSE54993 | WDR1 | 9948 | 10 | 0 | 60 | |
| GSE54994 | WDR1 | 9948 | 4 | 12 | 37 | |
| GSE60625 | WDR1 | 9948 | 0 | 0 | 11 | |
| GSE74703 | WDR1 | 9948 | 1 | 13 | 22 | |
| GSE74704 | WDR1 | 9948 | 0 | 11 | 9 | |
| TCGA | WDR1 | 9948 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 191; Total Number of normals: 270.
Somatic mutations of WDR1:
Generating mutation plots.
Highly correlated genes for WDR1:
Showing top 20/637 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR1 | GNG2 | 0.778007 | 3 | 0 | 3 |
| WDR1 | UROS | 0.727392 | 3 | 0 | 3 |
| WDR1 | ARMC9 | 0.72561 | 3 | 0 | 3 |
| WDR1 | MYH3 | 0.709608 | 3 | 0 | 3 |
| WDR1 | ADCK1 | 0.704145 | 3 | 0 | 3 |
| WDR1 | RAB28 | 0.7008 | 5 | 0 | 5 |
| WDR1 | RHOC | 0.699354 | 3 | 0 | 3 |
| WDR1 | GALNT2 | 0.699349 | 3 | 0 | 3 |
| WDR1 | TSEN34 | 0.694654 | 3 | 0 | 3 |
| WDR1 | PLXNB1 | 0.69346 | 4 | 0 | 4 |
| WDR1 | MTMR12 | 0.691472 | 3 | 0 | 3 |
| WDR1 | ARHGEF7 | 0.688146 | 4 | 0 | 3 |
| WDR1 | KLHL9 | 0.686948 | 3 | 0 | 3 |
| WDR1 | SYNC | 0.686031 | 4 | 0 | 3 |
| WDR1 | MAN2B2 | 0.68366 | 7 | 0 | 6 |
| WDR1 | BTN2A1 | 0.683031 | 3 | 0 | 3 |
| WDR1 | DDX42 | 0.681118 | 3 | 0 | 3 |
| WDR1 | NIPAL3 | 0.67446 | 5 | 0 | 5 |
| WDR1 | TADA2B | 0.672338 | 7 | 0 | 7 |
| WDR1 | C2CD2 | 0.671601 | 4 | 0 | 3 |
For details and further investigation, click here
