| Full name: AF4/FMR2 family member 3 | Alias Symbol: MLLT2-like | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 3899 | HGNC ID: HGNC:6473 | Ensembl Gene: ENSG00000144218 | OMIM ID: 601464 |
| Drug and gene relationship at DGIdb | |||
Expression of AFF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AFF3 | 3899 | 227198_at | -1.8406 | 0.1852 | |
| GSE20347 | AFF3 | 3899 | 205734_s_at | -0.0545 | 0.5003 | |
| GSE23400 | AFF3 | 3899 | 205735_s_at | -0.0544 | 0.0399 | |
| GSE26886 | AFF3 | 3899 | 205734_s_at | 0.2077 | 0.0918 | |
| GSE29001 | AFF3 | 3899 | 205735_s_at | -0.1107 | 0.3061 | |
| GSE38129 | AFF3 | 3899 | 205734_s_at | -0.1274 | 0.0236 | |
| GSE45670 | AFF3 | 3899 | 205734_s_at | -0.0219 | 0.8361 | |
| GSE63941 | AFF3 | 3899 | 227198_at | -4.2254 | 0.0000 | |
| GSE77861 | AFF3 | 3899 | 242078_at | -0.1162 | 0.1772 | |
| GSE97050 | AFF3 | 3899 | A_23_P373464 | -1.3630 | 0.1043 | |
| SRP007169 | AFF3 | 3899 | RNAseq | 0.2364 | 0.7815 | |
| SRP064894 | AFF3 | 3899 | RNAseq | -1.4992 | 0.0000 | |
| SRP133303 | AFF3 | 3899 | RNAseq | -1.4305 | 0.0000 | |
| SRP159526 | AFF3 | 3899 | RNAseq | -2.0790 | 0.0000 | |
| SRP193095 | AFF3 | 3899 | RNAseq | -0.6123 | 0.0068 | |
| SRP219564 | AFF3 | 3899 | RNAseq | -1.5720 | 0.0686 | |
| TCGA | AFF3 | 3899 | RNAseq | -1.7422 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by AFF3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of AFF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AFF3 | 3899 | 6 | 2 | 22 | |
| GSE20123 | AFF3 | 3899 | 6 | 2 | 22 | |
| GSE43470 | AFF3 | 3899 | 4 | 1 | 38 | |
| GSE46452 | AFF3 | 3899 | 2 | 3 | 54 | |
| GSE47630 | AFF3 | 3899 | 7 | 0 | 33 | |
| GSE54993 | AFF3 | 3899 | 0 | 6 | 64 | |
| GSE54994 | AFF3 | 3899 | 10 | 0 | 43 | |
| GSE60625 | AFF3 | 3899 | 0 | 3 | 8 | |
| GSE74703 | AFF3 | 3899 | 4 | 1 | 31 | |
| GSE74704 | AFF3 | 3899 | 4 | 1 | 15 | |
| TCGA | AFF3 | 3899 | 35 | 5 | 56 |
Total number of gains: 78; Total number of losses: 24; Total Number of normals: 386.
Somatic mutations of AFF3:
Generating mutation plots.
Highly correlated genes for AFF3:
Showing top 20/561 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AFF3 | MRVI1 | 0.92213 | 3 | 0 | 3 |
| AFF3 | TCF21 | 0.918102 | 3 | 0 | 3 |
| AFF3 | FGF7 | 0.908985 | 3 | 0 | 3 |
| AFF3 | ZNF25 | 0.89418 | 3 | 0 | 3 |
| AFF3 | MFAP4 | 0.884808 | 3 | 0 | 3 |
| AFF3 | SVEP1 | 0.884073 | 3 | 0 | 3 |
| AFF3 | MAN1C1 | 0.881881 | 3 | 0 | 3 |
| AFF3 | FOXF1 | 0.881191 | 3 | 0 | 3 |
| AFF3 | RSPO3 | 0.880866 | 3 | 0 | 3 |
| AFF3 | LMOD1 | 0.880619 | 3 | 0 | 3 |
| AFF3 | ITGA1 | 0.877443 | 3 | 0 | 3 |
| AFF3 | LRRK2 | 0.875594 | 3 | 0 | 3 |
| AFF3 | CTSO | 0.864899 | 3 | 0 | 3 |
| AFF3 | BNC2 | 0.864083 | 3 | 0 | 3 |
| AFF3 | CNN1 | 0.858882 | 3 | 0 | 3 |
| AFF3 | CELF2 | 0.857212 | 3 | 0 | 3 |
| AFF3 | NEXN | 0.849911 | 3 | 0 | 3 |
| AFF3 | PLN | 0.846823 | 3 | 0 | 3 |
| AFF3 | ZCCHC24 | 0.844977 | 3 | 0 | 3 |
| AFF3 | PRUNE2 | 0.840455 | 3 | 0 | 3 |
For details and further investigation, click here
