| Full name: dachsous cadherin-related 1 | Alias Symbol: FIB1|KIAA1773|FLJ11790|CDHR6 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 8642 | HGNC ID: HGNC:13681 | Ensembl Gene: ENSG00000166341 | OMIM ID: 603057 |
| Drug and gene relationship at DGIdb | |||
Expression of DCHS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCHS1 | 8642 | 222101_s_at | -0.5452 | 0.4158 | |
| GSE20347 | DCHS1 | 8642 | 222101_s_at | 0.3111 | 0.0948 | |
| GSE23400 | DCHS1 | 8642 | 222101_s_at | -0.1069 | 0.3471 | |
| GSE26886 | DCHS1 | 8642 | 222101_s_at | 1.3579 | 0.0001 | |
| GSE29001 | DCHS1 | 8642 | 222101_s_at | 0.1976 | 0.5397 | |
| GSE38129 | DCHS1 | 8642 | 222101_s_at | -0.1056 | 0.8109 | |
| GSE45670 | DCHS1 | 8642 | 222101_s_at | -1.0197 | 0.0109 | |
| GSE63941 | DCHS1 | 8642 | 222101_s_at | -3.0616 | 0.0003 | |
| GSE77861 | DCHS1 | 8642 | 222101_s_at | 0.1143 | 0.6935 | |
| GSE97050 | DCHS1 | 8642 | A_23_P98645 | -0.2740 | 0.4529 | |
| SRP007169 | DCHS1 | 8642 | RNAseq | 3.2462 | 0.0000 | |
| SRP008496 | DCHS1 | 8642 | RNAseq | 4.3035 | 0.0000 | |
| SRP064894 | DCHS1 | 8642 | RNAseq | 0.4572 | 0.1695 | |
| SRP133303 | DCHS1 | 8642 | RNAseq | 0.1312 | 0.6732 | |
| SRP159526 | DCHS1 | 8642 | RNAseq | 0.2103 | 0.6088 | |
| SRP193095 | DCHS1 | 8642 | RNAseq | 1.1353 | 0.0003 | |
| SRP219564 | DCHS1 | 8642 | RNAseq | 0.0209 | 0.9759 | |
| TCGA | DCHS1 | 8642 | RNAseq | -0.4597 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by DCHS1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DCHS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCHS1 | 8642 | 1 | 11 | 18 | |
| GSE20123 | DCHS1 | 8642 | 1 | 11 | 18 | |
| GSE43470 | DCHS1 | 8642 | 1 | 8 | 34 | |
| GSE46452 | DCHS1 | 8642 | 7 | 8 | 44 | |
| GSE47630 | DCHS1 | 8642 | 2 | 12 | 26 | |
| GSE54993 | DCHS1 | 8642 | 3 | 1 | 66 | |
| GSE54994 | DCHS1 | 8642 | 2 | 12 | 39 | |
| GSE60625 | DCHS1 | 8642 | 0 | 0 | 11 | |
| GSE74703 | DCHS1 | 8642 | 1 | 6 | 29 | |
| GSE74704 | DCHS1 | 8642 | 0 | 8 | 12 | |
| TCGA | DCHS1 | 8642 | 9 | 38 | 49 |
Total number of gains: 27; Total number of losses: 115; Total Number of normals: 346.
Somatic mutations of DCHS1:
Generating mutation plots.
Highly correlated genes for DCHS1:
Showing top 20/1391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCHS1 | DIXDC1 | 0.84391 | 6 | 0 | 6 |
| DCHS1 | MAGI2-AS3 | 0.838955 | 4 | 0 | 4 |
| DCHS1 | TBX5 | 0.827092 | 5 | 0 | 5 |
| DCHS1 | C11orf96 | 0.82161 | 5 | 0 | 5 |
| DCHS1 | ST6GALNAC3 | 0.818909 | 4 | 0 | 4 |
| DCHS1 | GNG2 | 0.804849 | 4 | 0 | 4 |
| DCHS1 | FXYD6 | 0.799518 | 8 | 0 | 8 |
| DCHS1 | FGF7 | 0.783658 | 6 | 0 | 6 |
| DCHS1 | FIBIN | 0.783612 | 5 | 0 | 4 |
| DCHS1 | DIAPH2 | 0.780839 | 4 | 0 | 4 |
| DCHS1 | KDSR | 0.780489 | 3 | 0 | 3 |
| DCHS1 | SMTN | 0.780126 | 5 | 0 | 5 |
| DCHS1 | MIR100HG | 0.77831 | 4 | 0 | 4 |
| DCHS1 | LRFN5 | 0.77711 | 3 | 0 | 3 |
| DCHS1 | RUNX1T1 | 0.776617 | 5 | 0 | 4 |
| DCHS1 | JAM3 | 0.774144 | 11 | 0 | 10 |
| DCHS1 | PMP22 | 0.773831 | 10 | 0 | 9 |
| DCHS1 | OLFML1 | 0.773134 | 9 | 0 | 8 |
| DCHS1 | DZIP1L | 0.770428 | 4 | 0 | 4 |
| DCHS1 | ANXA6 | 0.769458 | 10 | 0 | 9 |
For details and further investigation, click here
