| Full name: glutamate ionotropic receptor kainate type subunit 5 | Alias Symbol: GluK5|KA2 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 2901 | HGNC ID: HGNC:4583 | Ensembl Gene: ENSG00000105737 | OMIM ID: 600283 |
| Drug and gene relationship at DGIdb | |||
GRIK5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04724 | Glutamatergic synapse |
Expression of GRIK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIK5 | 2901 | 217509_x_at | -0.1150 | 0.7160 | |
| GSE20347 | GRIK5 | 2901 | 217509_x_at | 0.0093 | 0.9326 | |
| GSE23400 | GRIK5 | 2901 | 217509_x_at | -0.1234 | 0.0001 | |
| GSE26886 | GRIK5 | 2901 | 217509_x_at | 0.1221 | 0.2838 | |
| GSE29001 | GRIK5 | 2901 | 217509_x_at | -0.3125 | 0.0997 | |
| GSE38129 | GRIK5 | 2901 | 217509_x_at | -0.1785 | 0.0627 | |
| GSE45670 | GRIK5 | 2901 | 217509_x_at | -0.0571 | 0.5450 | |
| GSE53622 | GRIK5 | 2901 | 88451 | -0.1594 | 0.0521 | |
| GSE53624 | GRIK5 | 2901 | 88451 | -0.2758 | 0.0001 | |
| GSE63941 | GRIK5 | 2901 | 217509_x_at | 0.3871 | 0.0194 | |
| GSE77861 | GRIK5 | 2901 | 217509_x_at | 0.0364 | 0.8318 | |
| GSE97050 | GRIK5 | 2901 | A_23_P16063 | -0.4665 | 0.1936 | |
| SRP064894 | GRIK5 | 2901 | RNAseq | -0.5430 | 0.0926 | |
| SRP133303 | GRIK5 | 2901 | RNAseq | -1.7934 | 0.0000 | |
| SRP159526 | GRIK5 | 2901 | RNAseq | -0.5057 | 0.3730 | |
| SRP219564 | GRIK5 | 2901 | RNAseq | -0.7925 | 0.4080 | |
| TCGA | GRIK5 | 2901 | RNAseq | -1.0886 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GRIK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIK5 | 2901 | 4 | 4 | 22 | |
| GSE20123 | GRIK5 | 2901 | 4 | 3 | 23 | |
| GSE43470 | GRIK5 | 2901 | 3 | 11 | 29 | |
| GSE46452 | GRIK5 | 2901 | 47 | 1 | 11 | |
| GSE47630 | GRIK5 | 2901 | 8 | 6 | 26 | |
| GSE54993 | GRIK5 | 2901 | 17 | 4 | 49 | |
| GSE54994 | GRIK5 | 2901 | 7 | 12 | 34 | |
| GSE60625 | GRIK5 | 2901 | 9 | 0 | 2 | |
| GSE74703 | GRIK5 | 2901 | 3 | 7 | 26 | |
| GSE74704 | GRIK5 | 2901 | 4 | 1 | 15 | |
| TCGA | GRIK5 | 2901 | 14 | 15 | 67 |
Total number of gains: 120; Total number of losses: 64; Total Number of normals: 304.
Somatic mutations of GRIK5:
Generating mutation plots.
Highly correlated genes for GRIK5:
Showing top 20/1265 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIK5 | C22orf23 | 0.771114 | 3 | 0 | 3 |
| GRIK5 | FAM131A | 0.765659 | 3 | 0 | 3 |
| GRIK5 | BHLHA9 | 0.732923 | 3 | 0 | 3 |
| GRIK5 | SCLY | 0.725484 | 3 | 0 | 3 |
| GRIK5 | NXPH3 | 0.715623 | 9 | 0 | 8 |
| GRIK5 | TBC1D10B | 0.709605 | 3 | 0 | 3 |
| GRIK5 | CHRNA6 | 0.704769 | 4 | 0 | 4 |
| GRIK5 | NXNL1 | 0.702733 | 4 | 0 | 3 |
| GRIK5 | IL25 | 0.701833 | 5 | 0 | 5 |
| GRIK5 | C1QTNF1 | 0.698988 | 3 | 0 | 3 |
| GRIK5 | KLHL14 | 0.696346 | 4 | 0 | 3 |
| GRIK5 | C11orf86 | 0.686397 | 4 | 0 | 4 |
| GRIK5 | ANKRD33 | 0.682672 | 4 | 0 | 3 |
| GRIK5 | ANKRD33B | 0.682385 | 4 | 0 | 4 |
| GRIK5 | DMGDH | 0.681976 | 4 | 0 | 3 |
| GRIK5 | CTU1 | 0.67963 | 3 | 0 | 3 |
| GRIK5 | TTLL9 | 0.679523 | 4 | 0 | 3 |
| GRIK5 | BPIFB4 | 0.676138 | 5 | 0 | 4 |
| GRIK5 | DNAJC5B | 0.675114 | 3 | 0 | 3 |
| GRIK5 | ZNF329 | 0.674568 | 3 | 0 | 3 |
For details and further investigation, click here
