| Full name: cholinergic receptor nicotinic alpha 6 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 8973 | HGNC ID: HGNC:15963 | Ensembl Gene: ENSG00000147434 | OMIM ID: 606888 |
| Drug and gene relationship at DGIdb | |||
CHRNA6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04725 | Cholinergic synapse |
Expression of CHRNA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA6 | 8973 | 207568_at | 0.0448 | 0.8823 | |
| GSE20347 | CHRNA6 | 8973 | 207568_at | -0.0500 | 0.4732 | |
| GSE23400 | CHRNA6 | 8973 | 207568_at | -0.0304 | 0.5759 | |
| GSE26886 | CHRNA6 | 8973 | 207568_at | -0.0633 | 0.4541 | |
| GSE29001 | CHRNA6 | 8973 | 207568_at | -0.0095 | 0.9593 | |
| GSE38129 | CHRNA6 | 8973 | 207568_at | -0.0725 | 0.2691 | |
| GSE45670 | CHRNA6 | 8973 | 207568_at | 0.0330 | 0.7120 | |
| GSE53622 | CHRNA6 | 8973 | 117954 | 1.0150 | 0.0000 | |
| GSE53624 | CHRNA6 | 8973 | 117954 | 1.0942 | 0.0000 | |
| GSE63941 | CHRNA6 | 8973 | 207568_at | 0.1617 | 0.2381 | |
| GSE77861 | CHRNA6 | 8973 | 207568_at | -0.1054 | 0.2327 | |
| TCGA | CHRNA6 | 8973 | RNAseq | 4.0123 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CHRNA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA6 | 8973 | 9 | 5 | 16 | |
| GSE20123 | CHRNA6 | 8973 | 9 | 5 | 16 | |
| GSE43470 | CHRNA6 | 8973 | 8 | 6 | 29 | |
| GSE46452 | CHRNA6 | 8973 | 19 | 5 | 35 | |
| GSE47630 | CHRNA6 | 8973 | 22 | 1 | 17 | |
| GSE54993 | CHRNA6 | 8973 | 1 | 16 | 53 | |
| GSE54994 | CHRNA6 | 8973 | 18 | 8 | 27 | |
| GSE60625 | CHRNA6 | 8973 | 3 | 0 | 8 | |
| GSE74703 | CHRNA6 | 8973 | 7 | 5 | 24 | |
| GSE74704 | CHRNA6 | 8973 | 8 | 2 | 10 | |
| TCGA | CHRNA6 | 8973 | 39 | 21 | 36 |
Total number of gains: 143; Total number of losses: 74; Total Number of normals: 271.
Somatic mutations of CHRNA6:
Generating mutation plots.
Highly correlated genes for CHRNA6:
Showing top 20/549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA6 | ARHGEF38 | 0.732202 | 4 | 0 | 4 |
| CHRNA6 | ELSPBP1 | 0.722368 | 3 | 0 | 3 |
| CHRNA6 | EDA2R | 0.721732 | 4 | 0 | 4 |
| CHRNA6 | CYP2A7 | 0.717779 | 3 | 0 | 3 |
| CHRNA6 | HHLA1 | 0.715383 | 4 | 0 | 4 |
| CHRNA6 | GRIK5 | 0.704769 | 4 | 0 | 4 |
| CHRNA6 | MC2R | 0.703848 | 4 | 0 | 4 |
| CHRNA6 | MMP26 | 0.703163 | 3 | 0 | 3 |
| CHRNA6 | GDF5 | 0.697393 | 3 | 0 | 3 |
| CHRNA6 | IGF2-AS | 0.695309 | 3 | 0 | 3 |
| CHRNA6 | TBX10 | 0.687634 | 3 | 0 | 3 |
| CHRNA6 | MUC13 | 0.683909 | 3 | 0 | 3 |
| CHRNA6 | MAS1 | 0.678567 | 4 | 0 | 3 |
| CHRNA6 | NR5A1 | 0.678497 | 5 | 0 | 4 |
| CHRNA6 | NPTXR | 0.675298 | 5 | 0 | 5 |
| CHRNA6 | SLCO1C1 | 0.665964 | 3 | 0 | 3 |
| CHRNA6 | GPR182 | 0.663069 | 6 | 0 | 5 |
| CHRNA6 | GJB4 | 0.660964 | 4 | 0 | 4 |
| CHRNA6 | AMN | 0.660813 | 5 | 0 | 4 |
| CHRNA6 | KIR2DS3 | 0.660531 | 5 | 0 | 4 |
For details and further investigation, click here
