| Full name: dimethylglycine dehydrogenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 29958 | HGNC ID: HGNC:24475 | Ensembl Gene: ENSG00000132837 | OMIM ID: 605849 |
| Drug and gene relationship at DGIdb | |||
Expression of DMGDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DMGDH | 29958 | 231790_at | -0.2607 | 0.2772 | |
| GSE26886 | DMGDH | 29958 | 231790_at | 0.0171 | 0.8608 | |
| GSE45670 | DMGDH | 29958 | 231790_at | -0.4039 | 0.0000 | |
| GSE53622 | DMGDH | 29958 | 32632 | 0.0450 | 0.5722 | |
| GSE53624 | DMGDH | 29958 | 32632 | 0.1946 | 0.0019 | |
| GSE63941 | DMGDH | 29958 | 231790_at | -0.6861 | 0.0287 | |
| GSE77861 | DMGDH | 29958 | 231790_at | 0.0113 | 0.8778 | |
| GSE97050 | DMGDH | 29958 | A_33_P3387716 | -0.2040 | 0.3950 | |
| SRP064894 | DMGDH | 29958 | RNAseq | -0.7249 | 0.0952 | |
| SRP133303 | DMGDH | 29958 | RNAseq | -1.9735 | 0.0000 | |
| SRP159526 | DMGDH | 29958 | RNAseq | -1.5918 | 0.0061 | |
| SRP219564 | DMGDH | 29958 | RNAseq | -0.3633 | 0.7228 | |
| TCGA | DMGDH | 29958 | RNAseq | -1.9277 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DMGDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DMGDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DMGDH | 29958 | 1 | 13 | 16 | |
| GSE20123 | DMGDH | 29958 | 1 | 13 | 16 | |
| GSE43470 | DMGDH | 29958 | 1 | 13 | 29 | |
| GSE46452 | DMGDH | 29958 | 0 | 28 | 31 | |
| GSE47630 | DMGDH | 29958 | 1 | 19 | 20 | |
| GSE54993 | DMGDH | 29958 | 8 | 1 | 61 | |
| GSE54994 | DMGDH | 29958 | 1 | 19 | 33 | |
| GSE60625 | DMGDH | 29958 | 0 | 0 | 11 | |
| GSE74703 | DMGDH | 29958 | 1 | 9 | 26 | |
| GSE74704 | DMGDH | 29958 | 1 | 6 | 13 | |
| TCGA | DMGDH | 29958 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of DMGDH:
Generating mutation plots.
Highly correlated genes for DMGDH:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DMGDH | SHISA8 | 0.782995 | 3 | 0 | 3 |
| DMGDH | KCNQ4 | 0.780067 | 5 | 0 | 5 |
| DMGDH | OR2T1 | 0.779737 | 3 | 0 | 3 |
| DMGDH | CTIF | 0.766211 | 3 | 0 | 3 |
| DMGDH | PNMA3 | 0.759717 | 3 | 0 | 3 |
| DMGDH | PRLH | 0.756228 | 3 | 0 | 3 |
| DMGDH | FAM131A | 0.75452 | 3 | 0 | 3 |
| DMGDH | CPLX2 | 0.753238 | 3 | 0 | 3 |
| DMGDH | DCDC1 | 0.748112 | 3 | 0 | 3 |
| DMGDH | SNAP91 | 0.741485 | 4 | 0 | 4 |
| DMGDH | ABTB1 | 0.735718 | 3 | 0 | 3 |
| DMGDH | NLGN2 | 0.730785 | 3 | 0 | 3 |
| DMGDH | DNAH10OS | 0.72933 | 3 | 0 | 3 |
| DMGDH | TPO | 0.728196 | 4 | 0 | 3 |
| DMGDH | FOXB1 | 0.725168 | 3 | 0 | 3 |
| DMGDH | SCN7A | 0.720974 | 3 | 0 | 3 |
| DMGDH | DNAH9 | 0.717847 | 3 | 0 | 3 |
| DMGDH | CLDN9 | 0.717373 | 3 | 0 | 3 |
| DMGDH | SLC26A1 | 0.716983 | 3 | 0 | 3 |
| DMGDH | OTOG | 0.714835 | 3 | 0 | 3 |
For details and further investigation, click here
