| Full name: selenocysteine lyase | Alias Symbol: SCL | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 51540 | HGNC ID: HGNC:18161 | Ensembl Gene: ENSG00000132330 | OMIM ID: 611056 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SCLY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCLY | 51540 | 221575_at | 0.8211 | 0.4454 | |
| GSE20347 | SCLY | 51540 | 221575_at | 0.3843 | 0.0191 | |
| GSE23400 | SCLY | 51540 | 221575_at | 0.2576 | 0.0007 | |
| GSE26886 | SCLY | 51540 | 219808_at | -0.0148 | 0.9190 | |
| GSE29001 | SCLY | 51540 | 219808_at | -0.0112 | 0.9463 | |
| GSE38129 | SCLY | 51540 | 221575_at | 0.3124 | 0.1150 | |
| GSE45670 | SCLY | 51540 | 221575_at | 0.5742 | 0.0035 | |
| GSE53622 | SCLY | 51540 | 39274 | 0.4912 | 0.0000 | |
| GSE53624 | SCLY | 51540 | 39274 | 0.4937 | 0.0000 | |
| GSE63941 | SCLY | 51540 | 221575_at | 0.5133 | 0.2759 | |
| GSE77861 | SCLY | 51540 | 221575_at | 0.8700 | 0.0018 | |
| GSE97050 | SCLY | 51540 | A_33_P3332126 | 0.4892 | 0.1791 | |
| SRP007169 | SCLY | 51540 | RNAseq | -0.0550 | 0.9304 | |
| SRP064894 | SCLY | 51540 | RNAseq | 0.6730 | 0.0013 | |
| SRP133303 | SCLY | 51540 | RNAseq | 0.7244 | 0.0022 | |
| SRP159526 | SCLY | 51540 | RNAseq | 0.8742 | 0.0109 | |
| SRP193095 | SCLY | 51540 | RNAseq | 0.4667 | 0.0115 | |
| SRP219564 | SCLY | 51540 | RNAseq | 0.6495 | 0.1060 | |
| TCGA | SCLY | 51540 | RNAseq | 0.0970 | 0.2322 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SCLY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCLY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCLY | 51540 | 1 | 12 | 17 | |
| GSE20123 | SCLY | 51540 | 1 | 12 | 17 | |
| GSE43470 | SCLY | 51540 | 1 | 9 | 33 | |
| GSE46452 | SCLY | 51540 | 0 | 5 | 54 | |
| GSE47630 | SCLY | 51540 | 4 | 5 | 31 | |
| GSE54993 | SCLY | 51540 | 3 | 2 | 65 | |
| GSE54994 | SCLY | 51540 | 8 | 10 | 35 | |
| GSE60625 | SCLY | 51540 | 0 | 3 | 8 | |
| GSE74703 | SCLY | 51540 | 1 | 7 | 28 | |
| GSE74704 | SCLY | 51540 | 1 | 5 | 14 | |
| TCGA | SCLY | 51540 | 12 | 27 | 57 |
Total number of gains: 32; Total number of losses: 97; Total Number of normals: 359.
Somatic mutations of SCLY:
Generating mutation plots.
Highly correlated genes for SCLY:
Showing top 20/306 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCLY | P2RY4 | 0.793276 | 3 | 0 | 3 |
| SCLY | SLC5A5 | 0.780541 | 3 | 0 | 3 |
| SCLY | GEMIN2 | 0.76941 | 3 | 0 | 3 |
| SCLY | OR10C1 | 0.753611 | 3 | 0 | 3 |
| SCLY | FOLR3 | 0.746778 | 3 | 0 | 3 |
| SCLY | HOXC9 | 0.74111 | 4 | 0 | 4 |
| SCLY | MAP3K10 | 0.737624 | 3 | 0 | 3 |
| SCLY | GRIK5 | 0.725484 | 3 | 0 | 3 |
| SCLY | STK11 | 0.724927 | 3 | 0 | 3 |
| SCLY | DMRT2 | 0.716417 | 3 | 0 | 3 |
| SCLY | CDCA5 | 0.712233 | 5 | 0 | 5 |
| SCLY | MPP2 | 0.709255 | 3 | 0 | 3 |
| SCLY | HIVEP2 | 0.708178 | 3 | 0 | 3 |
| SCLY | OSBP2 | 0.706866 | 3 | 0 | 3 |
| SCLY | CHRND | 0.696983 | 3 | 0 | 3 |
| SCLY | RNF168 | 0.684973 | 3 | 0 | 3 |
| SCLY | WDR78 | 0.684214 | 3 | 0 | 3 |
| SCLY | RBM28 | 0.683713 | 4 | 0 | 3 |
| SCLY | TNFAIP8L1 | 0.682801 | 5 | 0 | 5 |
| SCLY | IFITM5 | 0.682375 | 3 | 0 | 3 |
For details and further investigation, click here
