| Full name: chromodomain helicase DNA binding protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q15-q21.1 | ||
| Entrez ID: 1105 | HGNC ID: HGNC:1915 | Ensembl Gene: ENSG00000153922 | OMIM ID: 602118 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHD1 | 1105 | 204258_at | 0.2146 | 0.6555 | |
| GSE20347 | CHD1 | 1105 | 204258_at | -0.1211 | 0.5669 | |
| GSE23400 | CHD1 | 1105 | 204258_at | 0.3166 | 0.0010 | |
| GSE26886 | CHD1 | 1105 | 235791_x_at | 0.4888 | 0.0221 | |
| GSE29001 | CHD1 | 1105 | 204258_at | 0.1178 | 0.7885 | |
| GSE38129 | CHD1 | 1105 | 204258_at | -0.0175 | 0.9510 | |
| GSE45670 | CHD1 | 1105 | 204258_at | -0.1026 | 0.5644 | |
| GSE53622 | CHD1 | 1105 | 107401 | 0.0270 | 0.7472 | |
| GSE53624 | CHD1 | 1105 | 107401 | 0.0205 | 0.8032 | |
| GSE63941 | CHD1 | 1105 | 204258_at | 0.0721 | 0.9108 | |
| GSE77861 | CHD1 | 1105 | 204258_at | 0.4021 | 0.3315 | |
| GSE97050 | CHD1 | 1105 | A_23_P70201 | 0.0497 | 0.8760 | |
| SRP007169 | CHD1 | 1105 | RNAseq | 0.7899 | 0.0793 | |
| SRP008496 | CHD1 | 1105 | RNAseq | 0.8641 | 0.0048 | |
| SRP064894 | CHD1 | 1105 | RNAseq | -0.2709 | 0.2673 | |
| SRP133303 | CHD1 | 1105 | RNAseq | 0.3673 | 0.0032 | |
| SRP159526 | CHD1 | 1105 | RNAseq | -0.1838 | 0.4881 | |
| SRP193095 | CHD1 | 1105 | RNAseq | -0.0425 | 0.6579 | |
| SRP219564 | CHD1 | 1105 | RNAseq | -0.2463 | 0.4069 | |
| TCGA | CHD1 | 1105 | RNAseq | -0.0888 | 0.1111 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHD1 | 1105 | 1 | 13 | 16 | |
| GSE20123 | CHD1 | 1105 | 1 | 13 | 16 | |
| GSE43470 | CHD1 | 1105 | 3 | 9 | 31 | |
| GSE46452 | CHD1 | 1105 | 0 | 28 | 31 | |
| GSE47630 | CHD1 | 1105 | 0 | 20 | 20 | |
| GSE54993 | CHD1 | 1105 | 8 | 1 | 61 | |
| GSE54994 | CHD1 | 1105 | 1 | 18 | 34 | |
| GSE60625 | CHD1 | 1105 | 0 | 0 | 11 | |
| GSE74703 | CHD1 | 1105 | 2 | 7 | 27 | |
| GSE74704 | CHD1 | 1105 | 1 | 7 | 12 | |
| TCGA | CHD1 | 1105 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of CHD1:
Generating mutation plots.
Highly correlated genes for CHD1:
Showing top 20/587 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHD1 | GTF2H3 | 0.818931 | 3 | 0 | 3 |
| CHD1 | DIP2A | 0.790031 | 3 | 0 | 3 |
| CHD1 | CRK | 0.789844 | 3 | 0 | 3 |
| CHD1 | TRMT12 | 0.771777 | 3 | 0 | 3 |
| CHD1 | FAM98A | 0.763043 | 3 | 0 | 3 |
| CHD1 | MED29 | 0.762645 | 3 | 0 | 3 |
| CHD1 | ZNF417 | 0.762297 | 3 | 0 | 3 |
| CHD1 | MLH1 | 0.759542 | 4 | 0 | 4 |
| CHD1 | HSPA5 | 0.75773 | 3 | 0 | 3 |
| CHD1 | BRAT1 | 0.757583 | 3 | 0 | 3 |
| CHD1 | NSMCE2 | 0.754675 | 3 | 0 | 3 |
| CHD1 | MTX2 | 0.754498 | 3 | 0 | 3 |
| CHD1 | PPP1R21 | 0.753191 | 3 | 0 | 3 |
| CHD1 | ZNF121 | 0.747993 | 3 | 0 | 3 |
| CHD1 | NBEAL1 | 0.746029 | 3 | 0 | 3 |
| CHD1 | REV1 | 0.742307 | 3 | 0 | 3 |
| CHD1 | TYW3 | 0.741663 | 3 | 0 | 3 |
| CHD1 | TRIM5 | 0.741025 | 3 | 0 | 3 |
| CHD1 | RLIM | 0.733095 | 3 | 0 | 3 |
| CHD1 | GATAD2B | 0.728353 | 3 | 0 | 3 |
For details and further investigation, click here
