CYCS

 

Full name: cytochrome c, somatic Alias Symbol: HCS|CYC
Type: protein-coding gene Cytoband: 7p15.3
Entrez ID: 54205 HGNC ID: HGNC:19986 Ensembl Gene: ENSG00000172115 OMIM ID: 123970
Drug and gene relationship at DGIdb
Screen Evidence:

 

CYCS involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05134Legionellosis
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of CYCS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CYCS 54205 208905_at 0.2442 0.5220
GSE20347 CYCS 54205 208905_at 0.3377 0.0075
GSE23400 CYCS 54205 208905_at 0.3807 0.0000
GSE26886 CYCS 54205 208905_at -0.1684 0.3172
GSE29001 CYCS 54205 208905_at 0.2180 0.4168
GSE38129 CYCS 54205 208905_at 0.3400 0.0006
GSE45670 CYCS 54205 208905_at 0.4494 0.0001
GSE63941 CYCS 54205 208905_at 0.9775 0.0016
GSE77861 CYCS 54205 208905_at 0.0914 0.7851
GSE97050 CYCS 54205 A_33_P3313401 0.1387 0.7491
SRP007169 CYCS 54205 RNAseq 0.3247 0.3633
SRP008496 CYCS 54205 RNAseq 0.5709 0.0410
SRP064894 CYCS 54205 RNAseq 0.0030 0.9882
SRP133303 CYCS 54205 RNAseq 0.7528 0.0001
SRP159526 CYCS 54205 RNAseq 0.4187 0.2450
SRP193095 CYCS 54205 RNAseq -0.1742 0.2378
SRP219564 CYCS 54205 RNAseq -0.0371 0.9305
TCGA CYCS 54205 RNAseq -0.0136 0.7825

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CYCS expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of CYCS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CYCS 54205 16 1 13
GSE20123 CYCS 54205 16 1 13
GSE43470 CYCS 54205 4 0 39
GSE46452 CYCS 54205 10 2 47
GSE47630 CYCS 54205 9 1 30
GSE54993 CYCS 54205 0 6 64
GSE54994 CYCS 54205 21 2 30
GSE60625 CYCS 54205 0 0 11
GSE74703 CYCS 54205 4 0 32
GSE74704 CYCS 54205 10 1 9
TCGA CYCS 54205 56 5 35

Total number of gains: 146; Total number of losses: 19; Total Number of normals: 323.  

 

Somatic mutations of CYCS:

 

Generating mutation plots.

 

Highly correlated genes for CYCS:

 

Showing top 20/841 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CYCSGTF2H30.814457303
CYCSISCA20.804622303
CYCSPANK30.791615303
CYCSPET1170.775332303
CYCSELOVL70.761104303
CYCSBCAS40.751894303
CYCSGOT10.748712303
CYCSINTS120.741417303
CYCSEFTUD20.740743303
CYCSCOMMD20.739623303
CYCSMRPL500.736761505
CYCSPOLR1B0.735687404
CYCSALKBH60.732647303
CYCSMRPL470.731476504
CYCSBOLA30.730218404
CYCSDHX350.727462303
CYCSDPP90.722295303
CYCSCOCH0.719358505
CYCSSRFBP10.718165404
CYCSCMSS10.714496303

For details and further investigation, click here