| Full name: ALMS1 centrosome and basal body associated protein | Alias Symbol: KIAA0328 | ||
| Type: protein-coding gene | Cytoband: 2p13.1 | ||
| Entrez ID: 7840 | HGNC ID: HGNC:428 | Ensembl Gene: ENSG00000116127 | OMIM ID: 606844 |
| Drug and gene relationship at DGIdb | |||
Expression of ALMS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALMS1 | 7840 | 214221_at | 0.6168 | 0.1946 | |
| GSE20347 | ALMS1 | 7840 | 214707_x_at | 0.5336 | 0.0141 | |
| GSE23400 | ALMS1 | 7840 | 214707_x_at | 0.0382 | 0.5765 | |
| GSE26886 | ALMS1 | 7840 | 214707_x_at | 0.2491 | 0.1748 | |
| GSE29001 | ALMS1 | 7840 | 214707_x_at | 0.2021 | 0.2629 | |
| GSE38129 | ALMS1 | 7840 | 214707_x_at | 0.2847 | 0.2708 | |
| GSE45670 | ALMS1 | 7840 | 214707_x_at | 0.2409 | 0.0654 | |
| GSE53622 | ALMS1 | 7840 | 17756 | 0.3911 | 0.0000 | |
| GSE53624 | ALMS1 | 7840 | 17756 | 0.3777 | 0.0000 | |
| GSE63941 | ALMS1 | 7840 | 214221_at | 0.6656 | 0.3074 | |
| GSE77861 | ALMS1 | 7840 | 214707_x_at | 0.5447 | 0.1456 | |
| GSE97050 | ALMS1 | 7840 | A_33_P3332724 | -0.0085 | 0.9846 | |
| SRP007169 | ALMS1 | 7840 | RNAseq | 1.7768 | 0.0000 | |
| SRP008496 | ALMS1 | 7840 | RNAseq | 1.5492 | 0.0000 | |
| SRP064894 | ALMS1 | 7840 | RNAseq | 0.7600 | 0.0001 | |
| SRP133303 | ALMS1 | 7840 | RNAseq | 0.5328 | 0.0000 | |
| SRP159526 | ALMS1 | 7840 | RNAseq | 1.2551 | 0.0000 | |
| SRP193095 | ALMS1 | 7840 | RNAseq | 0.7141 | 0.0000 | |
| SRP219564 | ALMS1 | 7840 | RNAseq | 0.8748 | 0.0188 | |
| TCGA | ALMS1 | 7840 | RNAseq | 0.0838 | 0.2080 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ALMS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALMS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALMS1 | 7840 | 11 | 1 | 18 | |
| GSE20123 | ALMS1 | 7840 | 11 | 1 | 18 | |
| GSE43470 | ALMS1 | 7840 | 4 | 0 | 39 | |
| GSE46452 | ALMS1 | 7840 | 2 | 3 | 54 | |
| GSE47630 | ALMS1 | 7840 | 7 | 0 | 33 | |
| GSE54993 | ALMS1 | 7840 | 0 | 6 | 64 | |
| GSE54994 | ALMS1 | 7840 | 11 | 1 | 41 | |
| GSE60625 | ALMS1 | 7840 | 0 | 3 | 8 | |
| GSE74703 | ALMS1 | 7840 | 4 | 0 | 32 | |
| GSE74704 | ALMS1 | 7840 | 9 | 0 | 11 | |
| TCGA | ALMS1 | 7840 | 38 | 2 | 56 |
Total number of gains: 97; Total number of losses: 17; Total Number of normals: 374.
Somatic mutations of ALMS1:
Generating mutation plots.
Highly correlated genes for ALMS1:
Showing top 20/542 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALMS1 | DDX59 | 0.945026 | 4 | 0 | 4 |
| ALMS1 | CMBL | 0.928732 | 3 | 0 | 3 |
| ALMS1 | SLC35E1 | 0.924214 | 8 | 0 | 8 |
| ALMS1 | C9orf64 | 0.92166 | 4 | 0 | 4 |
| ALMS1 | HAUS2 | 0.920341 | 8 | 0 | 8 |
| ALMS1 | FBXW12 | 0.918136 | 7 | 0 | 7 |
| ALMS1 | ZNF611 | 0.91528 | 7 | 0 | 7 |
| ALMS1 | MZT2B | 0.908574 | 8 | 0 | 8 |
| ALMS1 | PRR11 | 0.905782 | 7 | 0 | 7 |
| ALMS1 | SLC22A3 | 0.890993 | 3 | 0 | 3 |
| ALMS1 | FAM161B | 0.862838 | 4 | 0 | 4 |
| ALMS1 | GTF2H3 | 0.841847 | 8 | 0 | 8 |
| ALMS1 | DEK | 0.827946 | 3 | 0 | 3 |
| ALMS1 | NLN | 0.822466 | 4 | 0 | 3 |
| ALMS1 | FUT8-AS1 | 0.816503 | 3 | 0 | 3 |
| ALMS1 | FGFR1 | 0.810363 | 6 | 0 | 5 |
| ALMS1 | SWT1 | 0.802616 | 3 | 0 | 3 |
| ALMS1 | USP34 | 0.791196 | 7 | 0 | 6 |
| ALMS1 | ZNF721 | 0.78626 | 11 | 0 | 9 |
| ALMS1 | DCLRE1C | 0.775238 | 8 | 0 | 8 |
For details and further investigation, click here
