| Full name: exocyst complex component 8 | Alias Symbol: SEC84|EXO84|Exo84p | ||
| Type: protein-coding gene | Cytoband: 1q42.2 | ||
| Entrez ID: 149371 | HGNC ID: HGNC:24659 | Ensembl Gene: ENSG00000116903 | OMIM ID: 615283 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC8 | 149371 | 227577_at | 0.5651 | 0.2050 | |
| GSE26886 | EXOC8 | 149371 | 227577_at | 0.0744 | 0.8383 | |
| GSE45670 | EXOC8 | 149371 | 227577_at | 0.2299 | 0.0931 | |
| GSE53622 | EXOC8 | 149371 | 50131 | -0.2039 | 0.0005 | |
| GSE53624 | EXOC8 | 149371 | 98740 | -0.0190 | 0.9047 | |
| GSE63941 | EXOC8 | 149371 | 227577_at | -0.6530 | 0.1022 | |
| GSE77861 | EXOC8 | 149371 | 227577_at | 0.4688 | 0.0657 | |
| GSE97050 | EXOC8 | 149371 | A_33_P3397051 | 0.1686 | 0.4853 | |
| SRP007169 | EXOC8 | 149371 | RNAseq | -0.2432 | 0.5227 | |
| SRP008496 | EXOC8 | 149371 | RNAseq | 0.1239 | 0.6733 | |
| SRP064894 | EXOC8 | 149371 | RNAseq | -0.1020 | 0.5784 | |
| SRP133303 | EXOC8 | 149371 | RNAseq | 0.1386 | 0.2198 | |
| SRP159526 | EXOC8 | 149371 | RNAseq | -0.2087 | 0.6300 | |
| SRP193095 | EXOC8 | 149371 | RNAseq | -0.1291 | 0.0887 | |
| SRP219564 | EXOC8 | 149371 | RNAseq | 0.0960 | 0.7875 | |
| TCGA | EXOC8 | 149371 | RNAseq | -0.0888 | 0.0809 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC8 | 149371 | 12 | 0 | 18 | |
| GSE20123 | EXOC8 | 149371 | 12 | 0 | 18 | |
| GSE43470 | EXOC8 | 149371 | 8 | 1 | 34 | |
| GSE46452 | EXOC8 | 149371 | 4 | 2 | 53 | |
| GSE47630 | EXOC8 | 149371 | 15 | 0 | 25 | |
| GSE54993 | EXOC8 | 149371 | 0 | 6 | 64 | |
| GSE54994 | EXOC8 | 149371 | 17 | 0 | 36 | |
| GSE60625 | EXOC8 | 149371 | 0 | 0 | 11 | |
| GSE74703 | EXOC8 | 149371 | 8 | 1 | 27 | |
| GSE74704 | EXOC8 | 149371 | 6 | 0 | 14 | |
| TCGA | EXOC8 | 149371 | 45 | 3 | 48 |
Total number of gains: 127; Total number of losses: 13; Total Number of normals: 348.
Somatic mutations of EXOC8:
Generating mutation plots.
Highly correlated genes for EXOC8:
Showing top 20/546 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC8 | ALKBH6 | 0.848533 | 3 | 0 | 3 |
| EXOC8 | FBXW2 | 0.800202 | 3 | 0 | 3 |
| EXOC8 | ZNF146 | 0.797664 | 4 | 0 | 4 |
| EXOC8 | BRD4 | 0.796828 | 3 | 0 | 3 |
| EXOC8 | RNASEH2B | 0.796652 | 3 | 0 | 3 |
| EXOC8 | STYX | 0.793643 | 3 | 0 | 3 |
| EXOC8 | FASTKD3 | 0.792659 | 3 | 0 | 3 |
| EXOC8 | MIR3916 | 0.789623 | 3 | 0 | 3 |
| EXOC8 | NR2C1 | 0.789575 | 3 | 0 | 3 |
| EXOC8 | GTF2H3 | 0.787 | 3 | 0 | 3 |
| EXOC8 | ZNF544 | 0.786889 | 3 | 0 | 3 |
| EXOC8 | IMMP1L | 0.786642 | 3 | 0 | 3 |
| EXOC8 | WWP1 | 0.784195 | 3 | 0 | 3 |
| EXOC8 | TMEM97 | 0.76859 | 3 | 0 | 3 |
| EXOC8 | PPHLN1 | 0.767338 | 3 | 0 | 3 |
| EXOC8 | GAR1 | 0.766282 | 3 | 0 | 3 |
| EXOC8 | NEK4 | 0.765704 | 3 | 0 | 3 |
| EXOC8 | FUS | 0.760874 | 3 | 0 | 3 |
| EXOC8 | BRAT1 | 0.757068 | 3 | 0 | 3 |
| EXOC8 | ANKRD50 | 0.755818 | 3 | 0 | 3 |
For details and further investigation, click here
