| Full name: IKAROS family zinc finger 4 | Alias Symbol: Eos | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 64375 | HGNC ID: HGNC:13179 | Ensembl Gene: ENSG00000123411 | OMIM ID: 606239 |
| Drug and gene relationship at DGIdb | |||
Expression of IKZF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IKZF4 | 64375 | 226761_at | -0.0516 | 0.9352 | |
| GSE20347 | IKZF4 | 64375 | 208472_at | -0.0587 | 0.3193 | |
| GSE23400 | IKZF4 | 64375 | 208472_at | -0.1418 | 0.0000 | |
| GSE26886 | IKZF4 | 64375 | 208472_at | -0.0763 | 0.5092 | |
| GSE29001 | IKZF4 | 64375 | 208472_at | -0.2075 | 0.2417 | |
| GSE38129 | IKZF4 | 64375 | 208472_at | -0.0449 | 0.6000 | |
| GSE45670 | IKZF4 | 64375 | 226761_at | -0.3242 | 0.0061 | |
| GSE53622 | IKZF4 | 64375 | 20885 | 0.0401 | 0.6570 | |
| GSE53624 | IKZF4 | 64375 | 20885 | 0.0677 | 0.3263 | |
| GSE63941 | IKZF4 | 64375 | 226759_at | -1.4660 | 0.0000 | |
| GSE77861 | IKZF4 | 64375 | 208472_at | 0.0296 | 0.8141 | |
| GSE97050 | IKZF4 | 64375 | A_23_P378288 | -0.1585 | 0.6847 | |
| SRP007169 | IKZF4 | 64375 | RNAseq | 0.7787 | 0.1746 | |
| SRP008496 | IKZF4 | 64375 | RNAseq | 0.9110 | 0.0237 | |
| SRP064894 | IKZF4 | 64375 | RNAseq | -0.3828 | 0.1984 | |
| SRP133303 | IKZF4 | 64375 | RNAseq | 0.1967 | 0.2522 | |
| SRP159526 | IKZF4 | 64375 | RNAseq | -0.1572 | 0.6158 | |
| SRP193095 | IKZF4 | 64375 | RNAseq | 0.2271 | 0.1303 | |
| SRP219564 | IKZF4 | 64375 | RNAseq | -0.5239 | 0.2664 | |
| TCGA | IKZF4 | 64375 | RNAseq | -0.2987 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by IKZF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IKZF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IKZF4 | 64375 | 6 | 2 | 22 | |
| GSE20123 | IKZF4 | 64375 | 6 | 1 | 23 | |
| GSE43470 | IKZF4 | 64375 | 4 | 0 | 39 | |
| GSE46452 | IKZF4 | 64375 | 8 | 1 | 50 | |
| GSE47630 | IKZF4 | 64375 | 10 | 2 | 28 | |
| GSE54993 | IKZF4 | 64375 | 0 | 5 | 65 | |
| GSE54994 | IKZF4 | 64375 | 4 | 1 | 48 | |
| GSE60625 | IKZF4 | 64375 | 0 | 0 | 11 | |
| GSE74703 | IKZF4 | 64375 | 4 | 0 | 32 | |
| GSE74704 | IKZF4 | 64375 | 4 | 1 | 15 | |
| TCGA | IKZF4 | 64375 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of IKZF4:
Generating mutation plots.
Highly correlated genes for IKZF4:
Showing top 20/447 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IKZF4 | ZNF347 | 0.80426 | 3 | 0 | 3 |
| IKZF4 | NUDT16 | 0.800421 | 3 | 0 | 3 |
| IKZF4 | PBRM1 | 0.769716 | 3 | 0 | 3 |
| IKZF4 | C19orf18 | 0.7623 | 4 | 0 | 4 |
| IKZF4 | NELL1 | 0.739252 | 3 | 0 | 3 |
| IKZF4 | SARDH | 0.73794 | 4 | 0 | 4 |
| IKZF4 | STK40 | 0.724903 | 4 | 0 | 3 |
| IKZF4 | SYDE1 | 0.720132 | 4 | 0 | 3 |
| IKZF4 | ZNF791 | 0.71619 | 3 | 0 | 3 |
| IKZF4 | ANO6 | 0.711679 | 3 | 0 | 3 |
| IKZF4 | ZIK1 | 0.71138 | 4 | 0 | 4 |
| IKZF4 | ZNF626 | 0.709706 | 3 | 0 | 3 |
| IKZF4 | LDOC1 | 0.703904 | 4 | 0 | 4 |
| IKZF4 | ZFP82 | 0.700669 | 3 | 0 | 3 |
| IKZF4 | GRIK2 | 0.698674 | 4 | 0 | 3 |
| IKZF4 | ZNF703 | 0.698146 | 3 | 0 | 3 |
| IKZF4 | KBTBD8 | 0.697073 | 3 | 0 | 3 |
| IKZF4 | SPIN3 | 0.692109 | 3 | 0 | 3 |
| IKZF4 | TMEM220 | 0.691881 | 3 | 0 | 3 |
| IKZF4 | INO80D | 0.690168 | 6 | 0 | 6 |
For details and further investigation, click here
