| Full name: sarcosine dehydrogenase | Alias Symbol: SDH | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 1757 | HGNC ID: HGNC:10536 | Ensembl Gene: ENSG00000123453 | OMIM ID: 604455 |
| Drug and gene relationship at DGIdb | |||
Expression of SARDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SARDH | 1757 | 234586_at | -0.0841 | 0.6766 | |
| GSE20347 | SARDH | 1757 | 210063_at | -0.0487 | 0.5315 | |
| GSE23400 | SARDH | 1757 | 210063_at | -0.2482 | 0.0000 | |
| GSE26886 | SARDH | 1757 | 234536_at | 0.3766 | 0.0171 | |
| GSE29001 | SARDH | 1757 | 210063_at | -0.0311 | 0.8440 | |
| GSE38129 | SARDH | 1757 | 210063_at | -0.0911 | 0.2708 | |
| GSE45670 | SARDH | 1757 | 210063_at | -0.0113 | 0.9152 | |
| GSE53622 | SARDH | 1757 | 29765 | 0.2043 | 0.3359 | |
| GSE53624 | SARDH | 1757 | 29765 | 0.0530 | 0.6875 | |
| GSE63941 | SARDH | 1757 | 210063_at | -0.1686 | 0.4395 | |
| GSE77861 | SARDH | 1757 | 234536_at | -0.2390 | 0.3779 | |
| GSE97050 | SARDH | 1757 | A_33_P3257861 | 0.1690 | 0.5808 | |
| SRP133303 | SARDH | 1757 | RNAseq | 0.5515 | 0.2610 | |
| SRP159526 | SARDH | 1757 | RNAseq | 0.2551 | 0.6777 | |
| SRP219564 | SARDH | 1757 | RNAseq | 0.1224 | 0.7358 | |
| TCGA | SARDH | 1757 | RNAseq | -0.8773 | 0.0119 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SARDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SARDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SARDH | 1757 | 5 | 7 | 18 | |
| GSE20123 | SARDH | 1757 | 5 | 7 | 18 | |
| GSE43470 | SARDH | 1757 | 4 | 7 | 32 | |
| GSE46452 | SARDH | 1757 | 6 | 13 | 40 | |
| GSE47630 | SARDH | 1757 | 4 | 15 | 21 | |
| GSE54993 | SARDH | 1757 | 3 | 3 | 64 | |
| GSE54994 | SARDH | 1757 | 12 | 9 | 32 | |
| GSE60625 | SARDH | 1757 | 0 | 0 | 11 | |
| GSE74703 | SARDH | 1757 | 4 | 5 | 27 | |
| GSE74704 | SARDH | 1757 | 3 | 5 | 12 | |
| TCGA | SARDH | 1757 | 28 | 26 | 42 |
Total number of gains: 74; Total number of losses: 97; Total Number of normals: 317.
Somatic mutations of SARDH:
Generating mutation plots.
Highly correlated genes for SARDH:
Showing top 20/820 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SARDH | MAPK8IP3 | 0.806878 | 3 | 0 | 3 |
| SARDH | GTDC1 | 0.804948 | 3 | 0 | 3 |
| SARDH | ZNF358 | 0.794862 | 4 | 0 | 4 |
| SARDH | EGLN2 | 0.790754 | 3 | 0 | 3 |
| SARDH | KLHL31 | 0.78494 | 3 | 0 | 3 |
| SARDH | ACY1 | 0.782953 | 3 | 0 | 3 |
| SARDH | YTHDF3-AS1 | 0.775864 | 3 | 0 | 3 |
| SARDH | CNTF | 0.774743 | 3 | 0 | 3 |
| SARDH | ZNF594 | 0.772182 | 3 | 0 | 3 |
| SARDH | TMEM106A | 0.759855 | 3 | 0 | 3 |
| SARDH | NES | 0.75875 | 3 | 0 | 3 |
| SARDH | C8orf44 | 0.758104 | 3 | 0 | 3 |
| SARDH | MAST2 | 0.754333 | 4 | 0 | 4 |
| SARDH | MBLAC1 | 0.751633 | 3 | 0 | 3 |
| SARDH | CSNK1G2 | 0.746895 | 3 | 0 | 3 |
| SARDH | TFAP4 | 0.744774 | 3 | 0 | 3 |
| SARDH | IKZF4 | 0.73794 | 4 | 0 | 4 |
| SARDH | CCNK | 0.735863 | 3 | 0 | 3 |
| SARDH | CSF2RA | 0.734368 | 3 | 0 | 3 |
| SARDH | ZBTB12 | 0.733806 | 3 | 0 | 3 |
For details and further investigation, click here
