| Full name: synapse defective Rho GTPase homolog 1 | Alias Symbol: 7h3|FLJ13511|SYD1 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 85360 | HGNC ID: HGNC:25824 | Ensembl Gene: ENSG00000105137 | OMIM ID: 617377 |
| Drug and gene relationship at DGIdb | |||
Expression of SYDE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYDE1 | 85360 | 44702_at | 0.0203 | 0.9714 | |
| GSE20347 | SYDE1 | 85360 | 44702_at | 0.3054 | 0.0002 | |
| GSE23400 | SYDE1 | 85360 | 44702_at | -0.0092 | 0.8675 | |
| GSE26886 | SYDE1 | 85360 | 44702_at | 0.5452 | 0.0011 | |
| GSE29001 | SYDE1 | 85360 | 44702_at | 0.0576 | 0.8614 | |
| GSE38129 | SYDE1 | 85360 | 44702_at | -0.1099 | 0.4337 | |
| GSE45670 | SYDE1 | 85360 | 44702_at | -0.1127 | 0.4126 | |
| GSE53622 | SYDE1 | 85360 | 100932 | 0.4399 | 0.0024 | |
| GSE53624 | SYDE1 | 85360 | 100932 | 0.7367 | 0.0000 | |
| GSE63941 | SYDE1 | 85360 | 44702_at | -2.2476 | 0.0002 | |
| GSE77861 | SYDE1 | 85360 | 44702_at | 0.1042 | 0.3887 | |
| GSE97050 | SYDE1 | 85360 | A_23_P101796 | 0.0150 | 0.9658 | |
| SRP007169 | SYDE1 | 85360 | RNAseq | 1.3633 | 0.0407 | |
| SRP008496 | SYDE1 | 85360 | RNAseq | 2.3189 | 0.0000 | |
| SRP064894 | SYDE1 | 85360 | RNAseq | 0.8150 | 0.0023 | |
| SRP133303 | SYDE1 | 85360 | RNAseq | 0.6456 | 0.0366 | |
| SRP159526 | SYDE1 | 85360 | RNAseq | 0.2813 | 0.2654 | |
| SRP193095 | SYDE1 | 85360 | RNAseq | 1.5965 | 0.0000 | |
| SRP219564 | SYDE1 | 85360 | RNAseq | 0.3261 | 0.6115 | |
| TCGA | SYDE1 | 85360 | RNAseq | 0.0451 | 0.6517 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by SYDE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYDE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYDE1 | 85360 | 4 | 2 | 24 | |
| GSE20123 | SYDE1 | 85360 | 3 | 1 | 26 | |
| GSE43470 | SYDE1 | 85360 | 2 | 6 | 35 | |
| GSE46452 | SYDE1 | 85360 | 47 | 1 | 11 | |
| GSE47630 | SYDE1 | 85360 | 4 | 7 | 29 | |
| GSE54993 | SYDE1 | 85360 | 15 | 4 | 51 | |
| GSE54994 | SYDE1 | 85360 | 6 | 13 | 34 | |
| GSE60625 | SYDE1 | 85360 | 9 | 0 | 2 | |
| GSE74703 | SYDE1 | 85360 | 2 | 4 | 30 | |
| GSE74704 | SYDE1 | 85360 | 0 | 1 | 19 | |
| TCGA | SYDE1 | 85360 | 20 | 10 | 66 |
Total number of gains: 112; Total number of losses: 49; Total Number of normals: 327.
Somatic mutations of SYDE1:
Generating mutation plots.
Highly correlated genes for SYDE1:
Showing top 20/1227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYDE1 | KCNK2 | 0.751773 | 3 | 0 | 3 |
| SYDE1 | LRRC34 | 0.745361 | 3 | 0 | 3 |
| SYDE1 | LETM2 | 0.740969 | 3 | 0 | 3 |
| SYDE1 | NMNAT2 | 0.734755 | 4 | 0 | 4 |
| SYDE1 | CHRDL2 | 0.730431 | 3 | 0 | 3 |
| SYDE1 | CBL | 0.726565 | 3 | 0 | 3 |
| SYDE1 | PEAK1 | 0.725543 | 7 | 0 | 6 |
| SYDE1 | SLC45A1 | 0.72353 | 3 | 0 | 3 |
| SYDE1 | IKZF4 | 0.720132 | 4 | 0 | 3 |
| SYDE1 | FUNDC2 | 0.719607 | 4 | 0 | 4 |
| SYDE1 | FENDRR | 0.719143 | 3 | 0 | 3 |
| SYDE1 | ALKBH6 | 0.718797 | 3 | 0 | 3 |
| SYDE1 | LAMA4 | 0.717871 | 11 | 0 | 10 |
| SYDE1 | MCAM | 0.714759 | 10 | 0 | 10 |
| SYDE1 | MAP4 | 0.710253 | 7 | 0 | 7 |
| SYDE1 | HTR1D | 0.709915 | 3 | 0 | 3 |
| SYDE1 | VAT1L | 0.707042 | 5 | 0 | 4 |
| SYDE1 | GRIN3A | 0.705985 | 4 | 0 | 4 |
| SYDE1 | ZEB1 | 0.705706 | 3 | 0 | 3 |
| SYDE1 | ZBTB4 | 0.704149 | 3 | 0 | 3 |
For details and further investigation, click here
