| Full name: serine/threonine kinase 40 | Alias Symbol: MGC4796|SgK495 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 83931 | HGNC ID: HGNC:21373 | Ensembl Gene: ENSG00000196182 | OMIM ID: 609437 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of STK40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK40 | 83931 | 223852_s_at | -0.1719 | 0.7523 | |
| GSE26886 | STK40 | 83931 | 223852_s_at | -0.9038 | 0.0000 | |
| GSE45670 | STK40 | 83931 | 223852_s_at | -0.5308 | 0.0017 | |
| GSE53622 | STK40 | 83931 | 177116 | -1.1430 | 0.0000 | |
| GSE53624 | STK40 | 83931 | 177116 | -1.0072 | 0.0000 | |
| GSE63941 | STK40 | 83931 | 225015_s_at | 0.1789 | 0.5355 | |
| GSE77861 | STK40 | 83931 | 223852_s_at | -0.1105 | 0.7070 | |
| GSE97050 | STK40 | 83931 | A_23_P74229 | -0.6733 | 0.1148 | |
| SRP007169 | STK40 | 83931 | RNAseq | -1.8118 | 0.0000 | |
| SRP008496 | STK40 | 83931 | RNAseq | -1.6638 | 0.0000 | |
| SRP064894 | STK40 | 83931 | RNAseq | -1.3026 | 0.0000 | |
| SRP133303 | STK40 | 83931 | RNAseq | -0.7298 | 0.0014 | |
| SRP159526 | STK40 | 83931 | RNAseq | -0.7968 | 0.0194 | |
| SRP193095 | STK40 | 83931 | RNAseq | -0.6606 | 0.0000 | |
| SRP219564 | STK40 | 83931 | RNAseq | -1.3217 | 0.0011 | |
| TCGA | STK40 | 83931 | RNAseq | -0.2510 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by STK40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STK40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK40 | 83931 | 3 | 5 | 22 | |
| GSE20123 | STK40 | 83931 | 3 | 4 | 23 | |
| GSE43470 | STK40 | 83931 | 7 | 2 | 34 | |
| GSE46452 | STK40 | 83931 | 4 | 1 | 54 | |
| GSE47630 | STK40 | 83931 | 8 | 3 | 29 | |
| GSE54993 | STK40 | 83931 | 1 | 1 | 68 | |
| GSE54994 | STK40 | 83931 | 11 | 2 | 40 | |
| GSE60625 | STK40 | 83931 | 0 | 0 | 11 | |
| GSE74703 | STK40 | 83931 | 6 | 1 | 29 | |
| GSE74704 | STK40 | 83931 | 2 | 0 | 18 | |
| TCGA | STK40 | 83931 | 11 | 18 | 67 |
Total number of gains: 56; Total number of losses: 37; Total Number of normals: 395.
Somatic mutations of STK40:
Generating mutation plots.
Highly correlated genes for STK40:
Showing top 20/1080 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK40 | MKLN1 | 0.823667 | 3 | 0 | 3 |
| STK40 | THRAP3 | 0.801148 | 3 | 0 | 3 |
| STK40 | MKRN1 | 0.79497 | 3 | 0 | 3 |
| STK40 | CCDC7 | 0.784632 | 3 | 0 | 3 |
| STK40 | BLOC1S1 | 0.776158 | 5 | 0 | 5 |
| STK40 | CLEC3B | 0.775209 | 3 | 0 | 3 |
| STK40 | PDLIM2 | 0.770266 | 3 | 0 | 3 |
| STK40 | UQCRFS1 | 0.7632 | 4 | 0 | 4 |
| STK40 | ZCCHC10 | 0.759142 | 3 | 0 | 3 |
| STK40 | UBE2H | 0.756194 | 3 | 0 | 3 |
| STK40 | PPP4R1 | 0.755073 | 3 | 0 | 3 |
| STK40 | ANO10 | 0.754423 | 4 | 0 | 4 |
| STK40 | C6orf89 | 0.746783 | 3 | 0 | 3 |
| STK40 | ING2 | 0.745822 | 3 | 0 | 3 |
| STK40 | GNPTAB | 0.736509 | 3 | 0 | 3 |
| STK40 | CYP21A2 | 0.736157 | 3 | 0 | 3 |
| STK40 | TPCN1 | 0.735516 | 5 | 0 | 5 |
| STK40 | LRRFIP2 | 0.733449 | 5 | 0 | 5 |
| STK40 | CHCHD1 | 0.733025 | 4 | 0 | 4 |
| STK40 | C2CD2 | 0.731926 | 3 | 0 | 3 |
For details and further investigation, click here
