| Full name: polybromo 1 | Alias Symbol: BAF180|PB1 | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 55193 | HGNC ID: HGNC:30064 | Ensembl Gene: ENSG00000163939 | OMIM ID: 606083 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PBRM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBRM1 | 55193 | 223238_s_at | -0.3231 | 0.2292 | |
| GSE20347 | PBRM1 | 55193 | 220355_s_at | -0.5608 | 0.0001 | |
| GSE23400 | PBRM1 | 55193 | 220355_s_at | -0.3901 | 0.0000 | |
| GSE26886 | PBRM1 | 55193 | 223238_s_at | -0.8046 | 0.0001 | |
| GSE29001 | PBRM1 | 55193 | 220355_s_at | -0.6217 | 0.0246 | |
| GSE38129 | PBRM1 | 55193 | 220355_s_at | -0.5811 | 0.0010 | |
| GSE45670 | PBRM1 | 55193 | 223238_s_at | -0.2546 | 0.0507 | |
| GSE53622 | PBRM1 | 55193 | 31066 | -0.6682 | 0.0000 | |
| GSE53624 | PBRM1 | 55193 | 30405 | -0.8807 | 0.0000 | |
| GSE63941 | PBRM1 | 55193 | 223238_s_at | -1.3434 | 0.0010 | |
| GSE77861 | PBRM1 | 55193 | 223238_s_at | -1.1688 | 0.0447 | |
| GSE97050 | PBRM1 | 55193 | A_33_P3269578 | -0.3105 | 0.2401 | |
| SRP007169 | PBRM1 | 55193 | RNAseq | -0.0524 | 0.9054 | |
| SRP008496 | PBRM1 | 55193 | RNAseq | 0.1472 | 0.5985 | |
| SRP064894 | PBRM1 | 55193 | RNAseq | -0.6030 | 0.0041 | |
| SRP133303 | PBRM1 | 55193 | RNAseq | -0.4000 | 0.0012 | |
| SRP159526 | PBRM1 | 55193 | RNAseq | -0.7526 | 0.0003 | |
| SRP193095 | PBRM1 | 55193 | RNAseq | -0.6884 | 0.0000 | |
| SRP219564 | PBRM1 | 55193 | RNAseq | -0.7291 | 0.0077 | |
| TCGA | PBRM1 | 55193 | RNAseq | -0.1592 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PBRM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBRM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBRM1 | 55193 | 0 | 18 | 12 | |
| GSE20123 | PBRM1 | 55193 | 0 | 19 | 11 | |
| GSE43470 | PBRM1 | 55193 | 0 | 18 | 25 | |
| GSE46452 | PBRM1 | 55193 | 2 | 17 | 40 | |
| GSE47630 | PBRM1 | 55193 | 1 | 24 | 15 | |
| GSE54993 | PBRM1 | 55193 | 6 | 2 | 62 | |
| GSE54994 | PBRM1 | 55193 | 0 | 33 | 20 | |
| GSE60625 | PBRM1 | 55193 | 5 | 0 | 6 | |
| GSE74703 | PBRM1 | 55193 | 0 | 14 | 22 | |
| GSE74704 | PBRM1 | 55193 | 0 | 12 | 8 | |
| TCGA | PBRM1 | 55193 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of PBRM1:
Generating mutation plots.
Highly correlated genes for PBRM1:
Showing top 20/1467 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBRM1 | ZCCHC9 | 0.787452 | 3 | 0 | 3 |
| PBRM1 | IKZF4 | 0.769716 | 3 | 0 | 3 |
| PBRM1 | RAB5A | 0.749509 | 12 | 0 | 12 |
| PBRM1 | ZNF547 | 0.742175 | 3 | 0 | 3 |
| PBRM1 | C6orf62 | 0.740062 | 4 | 0 | 4 |
| PBRM1 | MAN2B2 | 0.738485 | 4 | 0 | 4 |
| PBRM1 | NFIA | 0.734273 | 7 | 0 | 7 |
| PBRM1 | MRVI1 | 0.725641 | 4 | 0 | 4 |
| PBRM1 | DUSP16 | 0.724014 | 3 | 0 | 3 |
| PBRM1 | IMPACT | 0.723259 | 3 | 0 | 3 |
| PBRM1 | HOXA3 | 0.72112 | 3 | 0 | 3 |
| PBRM1 | LRRK2 | 0.714796 | 7 | 0 | 7 |
| PBRM1 | LRRFIP2 | 0.714309 | 12 | 0 | 12 |
| PBRM1 | ATXN7 | 0.713169 | 11 | 0 | 9 |
| PBRM1 | DOCK8 | 0.711569 | 5 | 0 | 5 |
| PBRM1 | SACM1L | 0.706055 | 12 | 0 | 11 |
| PBRM1 | ZNF701 | 0.704302 | 3 | 0 | 3 |
| PBRM1 | KIAA1143 | 0.704239 | 4 | 0 | 4 |
| PBRM1 | ZNF776 | 0.701297 | 4 | 0 | 4 |
| PBRM1 | CLEC3B | 0.697795 | 3 | 0 | 3 |
For details and further investigation, click here
