| Full name: glutamate ionotropic receptor kainate type subunit 2 | Alias Symbol: GluK2|MRT6 | ||
| Type: protein-coding gene | Cytoband: 6q16.3 | ||
| Entrez ID: 2898 | HGNC ID: HGNC:4580 | Ensembl Gene: ENSG00000164418 | OMIM ID: 138244 |
| Drug and gene relationship at DGIdb | |||
GRIK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04724 | Glutamatergic synapse |
Expression of GRIK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIK2 | 2898 | 213845_at | -0.3583 | 0.1438 | |
| GSE20347 | GRIK2 | 2898 | 213845_at | 0.0746 | 0.5979 | |
| GSE23400 | GRIK2 | 2898 | 213845_at | -0.2372 | 0.0000 | |
| GSE26886 | GRIK2 | 2898 | 213845_at | 0.4526 | 0.0044 | |
| GSE29001 | GRIK2 | 2898 | 213845_at | -0.3579 | 0.0377 | |
| GSE38129 | GRIK2 | 2898 | 213845_at | -0.1114 | 0.6616 | |
| GSE45670 | GRIK2 | 2898 | 213845_at | -0.1138 | 0.8512 | |
| GSE53622 | GRIK2 | 2898 | 8424 | -0.5591 | 0.0052 | |
| GSE53624 | GRIK2 | 2898 | 8424 | -0.1405 | 0.2539 | |
| GSE63941 | GRIK2 | 2898 | 213845_at | -1.1241 | 0.0270 | |
| GSE77861 | GRIK2 | 2898 | 213845_at | 0.0479 | 0.6931 | |
| GSE97050 | GRIK2 | 2898 | A_33_P3307147 | -0.2145 | 0.3890 | |
| SRP133303 | GRIK2 | 2898 | RNAseq | -0.0435 | 0.8805 | |
| SRP219564 | GRIK2 | 2898 | RNAseq | -0.2667 | 0.7486 | |
| TCGA | GRIK2 | 2898 | RNAseq | -0.9339 | 0.0840 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GRIK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIK2 | 2898 | 1 | 5 | 24 | |
| GSE20123 | GRIK2 | 2898 | 1 | 4 | 25 | |
| GSE43470 | GRIK2 | 2898 | 3 | 3 | 37 | |
| GSE46452 | GRIK2 | 2898 | 2 | 11 | 46 | |
| GSE47630 | GRIK2 | 2898 | 8 | 6 | 26 | |
| GSE54993 | GRIK2 | 2898 | 4 | 2 | 64 | |
| GSE54994 | GRIK2 | 2898 | 8 | 8 | 37 | |
| GSE60625 | GRIK2 | 2898 | 0 | 1 | 10 | |
| GSE74703 | GRIK2 | 2898 | 2 | 3 | 31 | |
| GSE74704 | GRIK2 | 2898 | 0 | 1 | 19 | |
| TCGA | GRIK2 | 2898 | 7 | 24 | 65 |
Total number of gains: 36; Total number of losses: 68; Total Number of normals: 384.
Somatic mutations of GRIK2:
Generating mutation plots.
Highly correlated genes for GRIK2:
Showing top 20/684 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIK2 | CLMP | 0.777645 | 3 | 0 | 3 |
| GRIK2 | MBLAC1 | 0.769921 | 3 | 0 | 3 |
| GRIK2 | C11orf96 | 0.767112 | 4 | 0 | 4 |
| GRIK2 | SERTAD1 | 0.76402 | 3 | 0 | 3 |
| GRIK2 | BAG3 | 0.7607 | 3 | 0 | 3 |
| GRIK2 | MAFF | 0.756662 | 3 | 0 | 3 |
| GRIK2 | SIRT2 | 0.746399 | 3 | 0 | 3 |
| GRIK2 | CYP4V2 | 0.742697 | 3 | 0 | 3 |
| GRIK2 | WTIP | 0.740412 | 4 | 0 | 4 |
| GRIK2 | SCN4B | 0.738584 | 3 | 0 | 3 |
| GRIK2 | TMSB15B | 0.737684 | 3 | 0 | 3 |
| GRIK2 | MYOCD | 0.732139 | 4 | 0 | 3 |
| GRIK2 | FOXF1 | 0.729134 | 5 | 0 | 4 |
| GRIK2 | ST6GALNAC6 | 0.727054 | 3 | 0 | 3 |
| GRIK2 | TMTC1 | 0.713682 | 3 | 0 | 3 |
| GRIK2 | DPP4 | 0.706366 | 4 | 0 | 3 |
| GRIK2 | NKX6-1 | 0.705738 | 5 | 0 | 4 |
| GRIK2 | DSEL | 0.703139 | 4 | 0 | 4 |
| GRIK2 | HPSE2 | 0.702596 | 5 | 0 | 4 |
| GRIK2 | NTAN1 | 0.702016 | 3 | 0 | 3 |
For details and further investigation, click here
