| Full name: interleukin 23 receptor | Alias Symbol: IL-23R | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 149233 | HGNC ID: HGNC:19100 | Ensembl Gene: ENSG00000162594 | OMIM ID: 607562 |
| Drug and gene relationship at DGIdb | |||
IL23R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL23R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL23R | 149233 | 1561853_a_at | -0.0602 | 0.8483 | |
| GSE26886 | IL23R | 149233 | 1561853_a_at | -0.1442 | 0.1359 | |
| GSE45670 | IL23R | 149233 | 1561853_a_at | 0.1156 | 0.2327 | |
| GSE53622 | IL23R | 149233 | 7913 | -0.2824 | 0.0034 | |
| GSE53624 | IL23R | 149233 | 7913 | -0.2779 | 0.0018 | |
| GSE63941 | IL23R | 149233 | 1561853_a_at | -0.0089 | 0.9512 | |
| GSE77861 | IL23R | 149233 | 1561853_a_at | -0.0944 | 0.1845 | |
| SRP133303 | IL23R | 149233 | RNAseq | -0.6792 | 0.0104 | |
| TCGA | IL23R | 149233 | RNAseq | 0.2939 | 0.6440 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL23R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL23R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL23R | 149233 | 1 | 6 | 23 | |
| GSE20123 | IL23R | 149233 | 1 | 5 | 24 | |
| GSE43470 | IL23R | 149233 | 5 | 2 | 36 | |
| GSE46452 | IL23R | 149233 | 0 | 1 | 58 | |
| GSE47630 | IL23R | 149233 | 8 | 5 | 27 | |
| GSE54993 | IL23R | 149233 | 0 | 0 | 70 | |
| GSE54994 | IL23R | 149233 | 6 | 4 | 43 | |
| GSE60625 | IL23R | 149233 | 0 | 0 | 11 | |
| GSE74703 | IL23R | 149233 | 4 | 2 | 30 | |
| GSE74704 | IL23R | 149233 | 1 | 2 | 17 | |
| TCGA | IL23R | 149233 | 8 | 22 | 66 |
Total number of gains: 34; Total number of losses: 49; Total Number of normals: 405.
Somatic mutations of IL23R:
Generating mutation plots.
Highly correlated genes for IL23R:
Showing all 18 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL23R | SMR3B | 0.655887 | 3 | 0 | 3 |
| IL23R | AMACR | 0.645033 | 3 | 0 | 3 |
| IL23R | OR13C4 | 0.591375 | 5 | 0 | 3 |
| IL23R | OR2J2 | 0.587571 | 3 | 0 | 3 |
| IL23R | PRM1 | 0.58048 | 3 | 0 | 3 |
| IL23R | KCNK3 | 0.563364 | 4 | 0 | 3 |
| IL23R | CAMK2B | 0.560219 | 4 | 0 | 3 |
| IL23R | OXER1 | 0.560137 | 3 | 0 | 3 |
| IL23R | LILRA2 | 0.551208 | 4 | 0 | 3 |
| IL23R | SPAG11A | 0.542527 | 4 | 0 | 3 |
| IL23R | BPIFA2 | 0.536682 | 4 | 0 | 3 |
| IL23R | MPO | 0.533571 | 4 | 0 | 3 |
| IL23R | CNR2 | 0.531999 | 5 | 0 | 3 |
| IL23R | ZC4H2 | 0.530941 | 4 | 0 | 3 |
| IL23R | OR7E24 | 0.530558 | 4 | 0 | 3 |
| IL23R | GAL3ST3 | 0.526424 | 3 | 0 | 3 |
| IL23R | WWC2 | 0.525209 | 4 | 0 | 3 |
| IL23R | ADIG | 0.523893 | 5 | 0 | 3 |
For details and further investigation, click here
