CAMK2B

 

Full name: calcium/calmodulin dependent protein kinase II beta Alias Symbol: CAM2|CAMK2
Type: protein-coding gene Cytoband: 7p13
Entrez ID: 816 HGNC ID: HGNC:1461 Ensembl Gene: ENSG00000058404 OMIM ID: 607707
Related drugs: ALCOHOL, CAFFEINE, HYDROGEN PEROXIDE, IONOMYCIN, NIFEDIPINE, STAUROSPORINE, TRIFLUOPERAZINE, VASOPRESSIN... [more]

 

CAMK2B involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04066HIF-1 signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04971Gastric acid secretion
hsa05031Amphetamine addiction
hsa05152Tuberculosis
hsa05205Proteoglycans in cancer
hsa05214Glioma

 

Expression of CAMK2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CAMK2B 816 34846_at -0.0613 0.7789
GSE20347 CAMK2B 816 34846_at 0.0215 0.8254
GSE23400 CAMK2B 816 34846_at -0.0454 0.1348
GSE26886 CAMK2B 816 34846_at 0.0268 0.8406
GSE29001 CAMK2B 816 34846_at -0.2055 0.1028
GSE38129 CAMK2B 816 34846_at -0.0652 0.4232
GSE45670 CAMK2B 816 34846_at 0.1002 0.1449
GSE53622 CAMK2B 816 58070 0.2367 0.0075
GSE53624 CAMK2B 816 58070 0.3567 0.0000
GSE63941 CAMK2B 816 34846_at 0.3115 0.0137
GSE77861 CAMK2B 816 211483_x_at -0.1610 0.1160
GSE97050 CAMK2B 816 A_23_P42882 -0.0443 0.9425
SRP133303 CAMK2B 816 RNAseq -0.2135 0.4075
SRP159526 CAMK2B 816 RNAseq 2.1245 0.0249
SRP219564 CAMK2B 816 RNAseq 1.6607 0.0820
TCGA CAMK2B 816 RNAseq -0.5928 0.1584

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CAMK2B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CAMK2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CAMK2B 816 14 0 16
GSE20123 CAMK2B 816 13 0 17
GSE43470 CAMK2B 816 4 0 39
GSE46452 CAMK2B 816 11 1 47
GSE47630 CAMK2B 816 8 1 31
GSE54993 CAMK2B 816 0 8 62
GSE54994 CAMK2B 816 17 3 33
GSE60625 CAMK2B 816 0 0 11
GSE74703 CAMK2B 816 4 0 32
GSE74704 CAMK2B 816 7 0 13
TCGA CAMK2B 816 51 7 38

Total number of gains: 129; Total number of losses: 20; Total Number of normals: 339.  

 

Somatic mutations of CAMK2B:

 

Generating mutation plots.

 

Highly correlated genes for CAMK2B:

 

Showing top 20/1204 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CAMK2BCRHR20.750406606
CAMK2BCACNB10.749496505
CAMK2BFOXN3-AS20.732725606
CAMK2BSLC22A130.729844404
CAMK2BMUC5AC0.727111505
CAMK2BHAO20.726034505
CAMK2BP2RY40.718624706
CAMK2BSMYD10.715279303
CAMK2BIFNA100.71469505
CAMK2BG6PC20.711675706
CAMK2BPRODH20.709753908
CAMK2BCCL160.7077403
CAMK2BNCR30.705242505
CAMK2BSIRT30.701686807
CAMK2BKIF170.699637505
CAMK2BAMHR20.698395908
CAMK2BNOVA20.69775504
CAMK2BSLC28A10.697666606
CAMK2BNPTXR0.693855706
CAMK2BPROZ0.692072505

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