| Full name: potassium two pore domain channel subfamily K member 3 | Alias Symbol: K2p3.1|TASK|TASK-1 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 3777 | HGNC ID: HGNC:6278 | Ensembl Gene: ENSG00000171303 | OMIM ID: 603220 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
KCNK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04925 | Aldosterone synthesis and secretion |
Expression of KCNK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNK3 | 3777 | 228127_at | -0.2069 | 0.2611 | |
| GSE20347 | KCNK3 | 3777 | 205952_at | -0.1793 | 0.0809 | |
| GSE23400 | KCNK3 | 3777 | 205952_at | -0.3563 | 0.0000 | |
| GSE26886 | KCNK3 | 3777 | 228127_at | -0.1129 | 0.3448 | |
| GSE29001 | KCNK3 | 3777 | 205952_at | -0.1834 | 0.1536 | |
| GSE38129 | KCNK3 | 3777 | 205952_at | -0.7224 | 0.0090 | |
| GSE45670 | KCNK3 | 3777 | 228127_at | -0.0586 | 0.5692 | |
| GSE53622 | KCNK3 | 3777 | 60329 | -0.1292 | 0.1296 | |
| GSE53624 | KCNK3 | 3777 | 60329 | 0.0679 | 0.4331 | |
| GSE63941 | KCNK3 | 3777 | 228127_at | 0.3781 | 0.0221 | |
| GSE77861 | KCNK3 | 3777 | 228127_at | -0.2274 | 0.0722 | |
| GSE97050 | KCNK3 | 3777 | A_23_P91104 | -0.1919 | 0.6049 | |
| SRP064894 | KCNK3 | 3777 | RNAseq | -1.1685 | 0.0001 | |
| SRP133303 | KCNK3 | 3777 | RNAseq | -0.9171 | 0.0000 | |
| SRP159526 | KCNK3 | 3777 | RNAseq | -0.5243 | 0.5450 | |
| SRP193095 | KCNK3 | 3777 | RNAseq | 0.1803 | 0.2546 | |
| SRP219564 | KCNK3 | 3777 | RNAseq | -0.9122 | 0.2875 | |
| TCGA | KCNK3 | 3777 | RNAseq | -1.5034 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by KCNK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNK3 | 3777 | 11 | 2 | 17 | |
| GSE20123 | KCNK3 | 3777 | 11 | 2 | 17 | |
| GSE43470 | KCNK3 | 3777 | 3 | 1 | 39 | |
| GSE46452 | KCNK3 | 3777 | 3 | 4 | 52 | |
| GSE47630 | KCNK3 | 3777 | 8 | 0 | 32 | |
| GSE54993 | KCNK3 | 3777 | 0 | 6 | 64 | |
| GSE54994 | KCNK3 | 3777 | 10 | 0 | 43 | |
| GSE60625 | KCNK3 | 3777 | 0 | 3 | 8 | |
| GSE74703 | KCNK3 | 3777 | 3 | 0 | 33 | |
| GSE74704 | KCNK3 | 3777 | 9 | 1 | 10 | |
| TCGA | KCNK3 | 3777 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of KCNK3:
Generating mutation plots.
Highly correlated genes for KCNK3:
Showing top 20/775 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNK3 | DCDC1 | 0.828076 | 3 | 0 | 3 |
| KCNK3 | YY2 | 0.803318 | 3 | 0 | 3 |
| KCNK3 | SPRED3 | 0.785849 | 3 | 0 | 3 |
| KCNK3 | GRIK4 | 0.778908 | 3 | 0 | 3 |
| KCNK3 | PRSS38 | 0.770747 | 3 | 0 | 3 |
| KCNK3 | PLA2G2C | 0.765754 | 3 | 0 | 3 |
| KCNK3 | GRXCR2 | 0.76472 | 3 | 0 | 3 |
| KCNK3 | OR2T1 | 0.764336 | 3 | 0 | 3 |
| KCNK3 | MOB2 | 0.758981 | 3 | 0 | 3 |
| KCNK3 | SHISA8 | 0.756562 | 4 | 0 | 3 |
| KCNK3 | MRGPRG | 0.755203 | 3 | 0 | 3 |
| KCNK3 | BBC3 | 0.751285 | 3 | 0 | 3 |
| KCNK3 | PABPN1L | 0.749734 | 3 | 0 | 3 |
| KCNK3 | OR2T27 | 0.749411 | 3 | 0 | 3 |
| KCNK3 | KRTAP10-12 | 0.748004 | 3 | 0 | 3 |
| KCNK3 | OTOG | 0.746947 | 3 | 0 | 3 |
| KCNK3 | STRC | 0.746599 | 3 | 0 | 3 |
| KCNK3 | GDF7 | 0.744102 | 3 | 0 | 3 |
| KCNK3 | GPHA2 | 0.741067 | 3 | 0 | 3 |
| KCNK3 | ANKRD33B | 0.740728 | 3 | 0 | 3 |
For details and further investigation, click here
