Full name: insulin	Alias Symbol:
Type: protein-coding gene	Cytoband: 11p15.5
Entrez ID: 3630	HGNC ID: HGNC:6081	Ensembl Gene: ENSG00000254647	OMIM ID: 176730
Drug and gene relationship at DGIdb

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INS involved pathways:

KEGG pathway	Description	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04150	mTOR signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04152	AMPK signaling pathway	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04213	Longevity regulating pathway - multiple species	View
hsa04910	Insulin signaling pathway	View
hsa04911	Insulin secretion	View
hsa04913	Ovarian steroidogenesis	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04917	Prolactin signaling pathway	View
hsa04923	Regulation of lipolysis in adipocytes	View
hsa04930	Type II diabetes mellitus	View
hsa04931	Insulin resistance	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04950	Maturity onset diabetes of the young	View
hsa04960	Aldosterone-regulated sodium reabsorption	View
hsa05215	Prostate cancer	View

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Expression of INS:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	INS	3630	206598_at	-0.2409	0.3259	Show
GSE20347	INS	3630	206598_at	-0.0617	0.3528	Show
GSE23400	INS	3630	206598_at	-0.2071	0.0000	Show
GSE26886	INS	3630	206598_at	0.3179	0.0071	Show
GSE29001	INS	3630	206598_at	-0.1807	0.1381	Show
GSE38129	INS	3630	206598_at	-0.1322	0.0822	Show
GSE45670	INS	3630	206598_at	-0.0277	0.7770	Show
GSE53622	INS	3630	169256	0.2412	0.1734	Show
GSE53624	INS	3630	169256	0.3978	0.0018	Show
GSE63941	INS	3630	206598_at	-0.0441	0.7640	Show
GSE77861	INS	3630	206598_at	-0.1104	0.3888	Show
GSE97050	INS	3630	A_23_P1981	-0.4038	0.2987	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by INS expression:

 

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Copy number change of INS:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	INS	3630	1	11	18	Show
GSE20123	INS	3630	1	12	17	Show
GSE43470	INS	3630	1	9	33	Show
GSE46452	INS	3630	7	8	44	Show
GSE47630	INS	3630	4	12	24	Show
GSE54993	INS	3630	3	1	66	Show
GSE54994	INS	3630	1	12	40	Show
GSE60625	INS	3630	0	0	11	Show
GSE74703	INS	3630	1	7	28	Show
GSE74704	INS	3630	0	8	12	Show
TCGA	INS	3630	8	39	49	Show

Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.  Download Data

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Somatic mutations of INS:

 

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Highly correlated genes for INS:

 

Showing top 20/665 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
INS	ISLR2	0.698346	3	0	3
INS	ART1	0.693119	3	0	3
INS	SHOX	0.669698	3	0	3
INS	SYT9	0.665019	4	0	4
INS	PRDX6	0.66327	3	0	3
INS	ISYNA1	0.662847	3	0	3
INS	MOG	0.662282	5	0	4
INS	KLC1	0.662245	3	0	3
INS	KRTAP10-12	0.65975	3	0	3
INS	JSRP1	0.658598	4	0	4
INS	THRB	0.657536	3	0	3
INS	OR11A1	0.656264	5	0	4
INS	SYCN	0.655629	3	0	3
INS	SLC4A3	0.654242	3	0	3
INS	MAGEA8	0.653714	3	0	3
INS	TMSB4Y	0.649725	3	0	3
INS	FUT9	0.642624	3	0	3
INS	SIRPB1	0.641308	6	0	5
INS	CDRT15	0.641089	4	0	3
INS	AMER3	0.639778	4	0	3

For details and further investigation, click here