| Full name: peroxiredoxin 6 | Alias Symbol: AOP2|KIAA0106|1-Cys|NSGPx|PRX|aiPLA2|MGC46173|p29 | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 9588 | HGNC ID: HGNC:16753 | Ensembl Gene: ENSG00000117592 | OMIM ID: 602316 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRDX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDX6 | 9588 | 200844_s_at | -0.1880 | 0.4736 | |
| GSE20347 | PRDX6 | 9588 | 200844_s_at | -0.4952 | 0.0025 | |
| GSE23400 | PRDX6 | 9588 | 200844_s_at | -0.3874 | 0.0000 | |
| GSE26886 | PRDX6 | 9588 | 200844_s_at | -0.3288 | 0.1026 | |
| GSE29001 | PRDX6 | 9588 | 200844_s_at | -0.5491 | 0.0223 | |
| GSE38129 | PRDX6 | 9588 | 200844_s_at | -0.3239 | 0.0347 | |
| GSE45670 | PRDX6 | 9588 | 200844_s_at | -0.5617 | 0.0012 | |
| GSE53622 | PRDX6 | 9588 | 69949 | -0.7807 | 0.0000 | |
| GSE53624 | PRDX6 | 9588 | 69949 | -0.5008 | 0.0000 | |
| GSE63941 | PRDX6 | 9588 | 200844_s_at | 0.0733 | 0.8041 | |
| GSE77861 | PRDX6 | 9588 | 200844_s_at | -0.4428 | 0.1089 | |
| GSE97050 | PRDX6 | A_21_P0012646 | -0.7668 | 0.0828 | ||
| SRP007169 | PRDX6 | 9588 | RNAseq | -2.1642 | 0.0000 | |
| SRP008496 | PRDX6 | 9588 | RNAseq | -1.5365 | 0.0000 | |
| SRP064894 | PRDX6 | 9588 | RNAseq | -0.7150 | 0.0021 | |
| SRP133303 | PRDX6 | 9588 | RNAseq | -0.6826 | 0.0000 | |
| SRP159526 | PRDX6 | 9588 | RNAseq | -0.0753 | 0.7873 | |
| SRP193095 | PRDX6 | 9588 | RNAseq | -0.9239 | 0.0000 | |
| SRP219564 | PRDX6 | 9588 | RNAseq | -0.2957 | 0.3925 | |
| TCGA | PRDX6 | 9588 | RNAseq | -0.0296 | 0.5188 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PRDX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDX6 | 9588 | 12 | 0 | 18 | |
| GSE20123 | PRDX6 | 9588 | 12 | 0 | 18 | |
| GSE43470 | PRDX6 | 9588 | 7 | 2 | 34 | |
| GSE46452 | PRDX6 | 9588 | 3 | 1 | 55 | |
| GSE47630 | PRDX6 | 9588 | 14 | 0 | 26 | |
| GSE54993 | PRDX6 | 9588 | 0 | 6 | 64 | |
| GSE54994 | PRDX6 | 9588 | 15 | 0 | 38 | |
| GSE60625 | PRDX6 | 9588 | 0 | 0 | 11 | |
| GSE74703 | PRDX6 | 9588 | 7 | 2 | 27 | |
| GSE74704 | PRDX6 | 9588 | 5 | 0 | 15 | |
| TCGA | PRDX6 | 9588 | 41 | 4 | 51 |
Total number of gains: 116; Total number of losses: 15; Total Number of normals: 357.
Somatic mutations of PRDX6:
Generating mutation plots.
Highly correlated genes for PRDX6:
Showing top 20/1004 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDX6 | FNBP1 | 0.720854 | 3 | 0 | 3 |
| PRDX6 | HEATR5A | 0.719743 | 3 | 0 | 3 |
| PRDX6 | AMBRA1 | 0.698966 | 3 | 0 | 3 |
| PRDX6 | WDR26 | 0.685456 | 10 | 0 | 10 |
| PRDX6 | FCHO2 | 0.683885 | 6 | 0 | 6 |
| PRDX6 | HERPUD2 | 0.677765 | 3 | 0 | 3 |
| PRDX6 | ZNF879 | 0.675058 | 4 | 0 | 3 |
| PRDX6 | MRPS36 | 0.667096 | 6 | 0 | 5 |
| PRDX6 | INS | 0.66327 | 3 | 0 | 3 |
| PRDX6 | PEPD | 0.66251 | 4 | 0 | 4 |
| PRDX6 | C4orf3 | 0.658877 | 5 | 0 | 5 |
| PRDX6 | ALKBH7 | 0.658219 | 6 | 0 | 5 |
| PRDX6 | UBL5 | 0.655314 | 6 | 0 | 5 |
| PRDX6 | ZSWIM6 | 0.655059 | 5 | 0 | 4 |
| PRDX6 | KCTD6 | 0.652764 | 6 | 0 | 5 |
| PRDX6 | HINT3 | 0.651516 | 4 | 0 | 4 |
| PRDX6 | BRK1 | 0.649727 | 5 | 0 | 4 |
| PRDX6 | ZFP36L1 | 0.649094 | 3 | 0 | 3 |
| PRDX6 | AP3S1 | 0.64839 | 6 | 0 | 5 |
| PRDX6 | YTHDF2 | 0.647509 | 3 | 0 | 3 |
For details and further investigation, click here
