| Full name: thyroid hormone receptor beta | Alias Symbol: THRB1|THRB2|NR1A2|THR1|ERBA-BETA|GRTH | ||
| Type: protein-coding gene | Cytoband: 3p24.2 | ||
| Entrez ID: 7068 | HGNC ID: HGNC:11799 | Ensembl Gene: ENSG00000151090 | OMIM ID: 190160 |
| Drug and gene relationship at DGIdb | |||
THRB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04919 | Thyroid hormone signaling pathway |
Expression of THRB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THRB | 7068 | 228716_at | -0.8611 | 0.4683 | |
| GSE20347 | THRB | 7068 | 207044_at | -0.1089 | 0.1466 | |
| GSE23400 | THRB | 7068 | 207044_at | -0.3553 | 0.0000 | |
| GSE26886 | THRB | 7068 | 228716_at | -0.2134 | 0.5737 | |
| GSE29001 | THRB | 7068 | 207044_at | -0.4293 | 0.0030 | |
| GSE38129 | THRB | 7068 | 207044_at | -0.1374 | 0.0545 | |
| GSE45670 | THRB | 7068 | 228716_at | -1.5032 | 0.0006 | |
| GSE53622 | THRB | 7068 | 38137 | -1.0023 | 0.0000 | |
| GSE53624 | THRB | 7068 | 38137 | -0.7612 | 0.0000 | |
| GSE63941 | THRB | 7068 | 228716_at | -1.5362 | 0.0374 | |
| GSE77861 | THRB | 7068 | 207044_at | -0.2624 | 0.0055 | |
| GSE97050 | THRB | 7068 | A_33_P3663974 | -1.3521 | 0.1581 | |
| SRP007169 | THRB | 7068 | RNAseq | 0.6911 | 0.2584 | |
| SRP008496 | THRB | 7068 | RNAseq | 0.5563 | 0.2398 | |
| SRP064894 | THRB | 7068 | RNAseq | -0.5113 | 0.0385 | |
| SRP133303 | THRB | 7068 | RNAseq | -0.3608 | 0.2853 | |
| SRP159526 | THRB | 7068 | RNAseq | -0.5313 | 0.1691 | |
| SRP193095 | THRB | 7068 | RNAseq | -0.2785 | 0.2391 | |
| SRP219564 | THRB | 7068 | RNAseq | -0.3674 | 0.5931 | |
| TCGA | THRB | 7068 | RNAseq | -0.8748 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by THRB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THRB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THRB | 7068 | 0 | 18 | 12 | |
| GSE20123 | THRB | 7068 | 0 | 18 | 12 | |
| GSE43470 | THRB | 7068 | 0 | 20 | 23 | |
| GSE46452 | THRB | 7068 | 2 | 17 | 40 | |
| GSE47630 | THRB | 7068 | 1 | 24 | 15 | |
| GSE54993 | THRB | 7068 | 6 | 2 | 62 | |
| GSE54994 | THRB | 7068 | 1 | 32 | 20 | |
| GSE60625 | THRB | 7068 | 5 | 0 | 6 | |
| GSE74703 | THRB | 7068 | 0 | 17 | 19 | |
| GSE74704 | THRB | 7068 | 0 | 12 | 8 | |
| TCGA | THRB | 7068 | 0 | 70 | 26 |
Total number of gains: 15; Total number of losses: 230; Total Number of normals: 243.
Somatic mutations of THRB:
Generating mutation plots.
Highly correlated genes for THRB:
Showing top 20/1024 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THRB | LSM3 | 0.818364 | 3 | 0 | 3 |
| THRB | FOXN3 | 0.80071 | 3 | 0 | 3 |
| THRB | NDUFS4 | 0.771996 | 3 | 0 | 3 |
| THRB | NKAPL | 0.768784 | 3 | 0 | 3 |
| THRB | TTLL11 | 0.76086 | 3 | 0 | 3 |
| THRB | ENTPD2 | 0.759196 | 3 | 0 | 3 |
| THRB | EDA2R | 0.755458 | 4 | 0 | 4 |
| THRB | MYL6 | 0.746589 | 5 | 0 | 4 |
| THRB | SPAG6 | 0.74484 | 3 | 0 | 3 |
| THRB | PCBD2 | 0.734976 | 3 | 0 | 3 |
| THRB | FNDC5 | 0.734057 | 3 | 0 | 3 |
| THRB | PHYH | 0.732993 | 4 | 0 | 4 |
| THRB | ACAA1 | 0.730671 | 4 | 0 | 4 |
| THRB | NPY1R | 0.727922 | 3 | 0 | 3 |
| THRB | UGP2 | 0.727101 | 4 | 0 | 4 |
| THRB | CYS1 | 0.722577 | 4 | 0 | 4 |
| THRB | HOXC5 | 0.719971 | 4 | 0 | 4 |
| THRB | KCNG2 | 0.716646 | 4 | 0 | 4 |
| THRB | PRSS50 | 0.711218 | 3 | 0 | 3 |
| THRB | STBD1 | 0.710096 | 3 | 0 | 3 |
For details and further investigation, click here
