| Full name: kinesin light chain 1 | Alias Symbol: KNS2A|KLC|hKLC1S|hKLC1N|hKLC1P|hKLC1G|hKLC1R|hKLC1J|hKLC1B | ||
| Type: protein-coding gene | Cytoband: 14q32.33 | ||
| Entrez ID: 3831 | HGNC ID: HGNC:6387 | Ensembl Gene: ENSG00000126214 | OMIM ID: 600025 |
| Drug and gene relationship at DGIdb | |||
KLC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05132 | Salmonella infection |
Expression of KLC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLC1 | 3831 | 213656_s_at | -0.3415 | 0.3431 | |
| GSE20347 | KLC1 | 3831 | 213656_s_at | -0.0890 | 0.5484 | |
| GSE23400 | KLC1 | 3831 | 213656_s_at | -0.1047 | 0.1756 | |
| GSE26886 | KLC1 | 3831 | 213656_s_at | 0.6933 | 0.0009 | |
| GSE29001 | KLC1 | 3831 | 213656_s_at | -0.1587 | 0.4585 | |
| GSE38129 | KLC1 | 3831 | 213656_s_at | -0.2175 | 0.1257 | |
| GSE45670 | KLC1 | 3831 | 213656_s_at | -0.3671 | 0.0011 | |
| GSE53622 | KLC1 | 3831 | 23654 | -0.2216 | 0.0077 | |
| GSE53624 | KLC1 | 3831 | 73821 | -0.4217 | 0.0000 | |
| GSE63941 | KLC1 | 3831 | 213656_s_at | -1.4124 | 0.0095 | |
| GSE77861 | KLC1 | 3831 | 213656_s_at | 0.2069 | 0.5794 | |
| GSE97050 | KLC1 | 3831 | A_23_P2873 | -0.2562 | 0.2371 | |
| SRP007169 | KLC1 | 3831 | RNAseq | -0.6305 | 0.1089 | |
| SRP008496 | KLC1 | 3831 | RNAseq | -0.3722 | 0.1522 | |
| SRP064894 | KLC1 | 3831 | RNAseq | -0.0519 | 0.6991 | |
| SRP133303 | KLC1 | 3831 | RNAseq | -0.0180 | 0.9089 | |
| SRP159526 | KLC1 | 3831 | RNAseq | 0.1809 | 0.6064 | |
| SRP193095 | KLC1 | 3831 | RNAseq | 0.1290 | 0.3404 | |
| SRP219564 | KLC1 | 3831 | RNAseq | -0.1479 | 0.6445 | |
| TCGA | KLC1 | 3831 | RNAseq | -0.0163 | 0.7350 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KLC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLC1 | 3831 | 12 | 3 | 15 | |
| GSE20123 | KLC1 | 3831 | 11 | 2 | 17 | |
| GSE43470 | KLC1 | 3831 | 6 | 4 | 33 | |
| GSE46452 | KLC1 | 3831 | 18 | 4 | 37 | |
| GSE47630 | KLC1 | 3831 | 10 | 8 | 22 | |
| GSE54993 | KLC1 | 3831 | 3 | 8 | 59 | |
| GSE54994 | KLC1 | 3831 | 21 | 4 | 28 | |
| GSE60625 | KLC1 | 3831 | 0 | 2 | 9 | |
| GSE74703 | KLC1 | 3831 | 5 | 3 | 28 | |
| GSE74704 | KLC1 | 3831 | 5 | 2 | 13 | |
| TCGA | KLC1 | 3831 | 31 | 20 | 45 |
Total number of gains: 122; Total number of losses: 60; Total Number of normals: 306.
Somatic mutations of KLC1:
Generating mutation plots.
Highly correlated genes for KLC1:
Showing top 20/509 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLC1 | ZFP90 | 0.781012 | 3 | 0 | 3 |
| KLC1 | DMAP1 | 0.774289 | 3 | 0 | 3 |
| KLC1 | CYTH3 | 0.772664 | 4 | 0 | 4 |
| KLC1 | CCM2 | 0.766741 | 3 | 0 | 3 |
| KLC1 | ZNF609 | 0.762452 | 3 | 0 | 3 |
| KLC1 | RRAS2 | 0.75681 | 3 | 0 | 3 |
| KLC1 | SREK1IP1 | 0.754004 | 3 | 0 | 3 |
| KLC1 | LUC7L | 0.751391 | 4 | 0 | 4 |
| KLC1 | PDXDC1 | 0.749102 | 3 | 0 | 3 |
| KLC1 | KRTCAP2 | 0.745631 | 3 | 0 | 3 |
| KLC1 | PRICKLE2 | 0.743445 | 3 | 0 | 3 |
| KLC1 | ABCD4 | 0.743029 | 3 | 0 | 3 |
| KLC1 | C5orf24 | 0.736168 | 3 | 0 | 3 |
| KLC1 | FBXL17 | 0.735044 | 3 | 0 | 3 |
| KLC1 | ANKRD11 | 0.727326 | 3 | 0 | 3 |
| KLC1 | AKT1 | 0.723507 | 5 | 0 | 5 |
| KLC1 | ACY1 | 0.718848 | 3 | 0 | 3 |
| KLC1 | GPATCH2 | 0.718554 | 3 | 0 | 3 |
| KLC1 | SLC25A29 | 0.715651 | 4 | 0 | 3 |
| KLC1 | YWHAG | 0.714725 | 3 | 0 | 3 |
For details and further investigation, click here
