| Full name: importin 5 | Alias Symbol: IMB3|MGC2068|Pse1 | ||
| Type: protein-coding gene | Cytoband: 13q32.2 | ||
| Entrez ID: 3843 | HGNC ID: HGNC:6402 | Ensembl Gene: ENSG00000065150 | OMIM ID: 602008 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IPO5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IPO5 | 3843 | 211955_at | 0.3396 | 0.2781 | |
| GSE20347 | IPO5 | 3843 | 211954_s_at | 0.2662 | 0.2001 | |
| GSE23400 | IPO5 | 3843 | 211954_s_at | 0.2722 | 0.0038 | |
| GSE26886 | IPO5 | 3843 | 211955_at | 0.6575 | 0.0022 | |
| GSE29001 | IPO5 | 3843 | 211955_at | 0.0424 | 0.9088 | |
| GSE38129 | IPO5 | 3843 | 211954_s_at | 0.2171 | 0.1806 | |
| GSE45670 | IPO5 | 3843 | 211954_s_at | 0.0817 | 0.7070 | |
| GSE53622 | IPO5 | 3843 | 5495 | 0.3004 | 0.0005 | |
| GSE53624 | IPO5 | 3843 | 5495 | 0.3530 | 0.0000 | |
| GSE63941 | IPO5 | 3843 | 211955_at | 1.0690 | 0.0361 | |
| GSE77861 | IPO5 | 3843 | 211955_at | 0.0463 | 0.8907 | |
| GSE97050 | IPO5 | 3843 | A_24_P99071 | 0.1918 | 0.6244 | |
| SRP007169 | IPO5 | 3843 | RNAseq | 1.8549 | 0.0000 | |
| SRP008496 | IPO5 | 3843 | RNAseq | 1.9047 | 0.0000 | |
| SRP064894 | IPO5 | 3843 | RNAseq | 0.2465 | 0.0577 | |
| SRP133303 | IPO5 | 3843 | RNAseq | 0.2109 | 0.0303 | |
| SRP159526 | IPO5 | 3843 | RNAseq | -0.0063 | 0.9786 | |
| SRP193095 | IPO5 | 3843 | RNAseq | 0.1492 | 0.2837 | |
| SRP219564 | IPO5 | 3843 | RNAseq | 0.2435 | 0.5677 | |
| TCGA | IPO5 | 3843 | RNAseq | -0.0782 | 0.0635 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by IPO5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IPO5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IPO5 | 3843 | 4 | 9 | 17 | |
| GSE20123 | IPO5 | 3843 | 4 | 8 | 18 | |
| GSE43470 | IPO5 | 3843 | 4 | 12 | 27 | |
| GSE46452 | IPO5 | 3843 | 0 | 32 | 27 | |
| GSE47630 | IPO5 | 3843 | 3 | 26 | 11 | |
| GSE54993 | IPO5 | 3843 | 11 | 4 | 55 | |
| GSE54994 | IPO5 | 3843 | 3 | 12 | 38 | |
| GSE60625 | IPO5 | 3843 | 0 | 3 | 8 | |
| GSE74703 | IPO5 | 3843 | 3 | 10 | 23 | |
| GSE74704 | IPO5 | 3843 | 2 | 8 | 10 | |
| TCGA | IPO5 | 3843 | 14 | 34 | 48 |
Total number of gains: 48; Total number of losses: 158; Total Number of normals: 282.
Somatic mutations of IPO5:
Generating mutation plots.
Highly correlated genes for IPO5:
Showing top 20/859 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IPO5 | COMMD7 | 0.79957 | 3 | 0 | 3 |
| IPO5 | MRPS26 | 0.784906 | 3 | 0 | 3 |
| IPO5 | SUZ12 | 0.759722 | 3 | 0 | 3 |
| IPO5 | SIMC1 | 0.726865 | 3 | 0 | 3 |
| IPO5 | BTG1 | 0.723436 | 3 | 0 | 3 |
| IPO5 | ZXDA | 0.72069 | 3 | 0 | 3 |
| IPO5 | ZSCAN21 | 0.715138 | 4 | 0 | 4 |
| IPO5 | ZNF703 | 0.714937 | 3 | 0 | 3 |
| IPO5 | BOD1 | 0.712013 | 5 | 0 | 4 |
| IPO5 | SETD3 | 0.709883 | 3 | 0 | 3 |
| IPO5 | TMEM170A | 0.704877 | 3 | 0 | 3 |
| IPO5 | ZCCHC7 | 0.703609 | 3 | 0 | 3 |
| IPO5 | GOLGA5 | 0.70304 | 3 | 0 | 3 |
| IPO5 | AIFM1 | 0.698449 | 3 | 0 | 3 |
| IPO5 | AZIN1 | 0.690082 | 4 | 0 | 3 |
| IPO5 | ZBTB26 | 0.688764 | 3 | 0 | 3 |
| IPO5 | PARP8 | 0.686251 | 3 | 0 | 3 |
| IPO5 | INTS10 | 0.683384 | 3 | 0 | 3 |
| IPO5 | ZNF805 | 0.679713 | 3 | 0 | 3 |
| IPO5 | ZNF518B | 0.678776 | 3 | 0 | 3 |
For details and further investigation, click here
