| Full name: SUMO interacting motifs containing 1 | Alias Symbol: FLJ44216|OOMA1|PLEIAD | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 375484 | HGNC ID: HGNC:24779 | Ensembl Gene: ENSG00000170085 | OMIM ID: 618102 |
| Drug and gene relationship at DGIdb | |||
Expression of SIMC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIMC1 | 375484 | 228805_at | 0.4006 | 0.1306 | |
| GSE26886 | SIMC1 | 375484 | 228805_at | 1.2072 | 0.0022 | |
| GSE45670 | SIMC1 | 375484 | 228805_at | -0.1091 | 0.6935 | |
| GSE53622 | SIMC1 | 375484 | 5424 | -0.0188 | 0.8919 | |
| GSE53624 | SIMC1 | 375484 | 5424 | -0.0014 | 0.9918 | |
| GSE63941 | SIMC1 | 375484 | 228805_at | -0.3087 | 0.8420 | |
| GSE77861 | SIMC1 | 375484 | 228805_at | 0.3996 | 0.3323 | |
| SRP007169 | SIMC1 | 375484 | RNAseq | 0.8577 | 0.1728 | |
| SRP008496 | SIMC1 | 375484 | RNAseq | 0.5383 | 0.2760 | |
| SRP064894 | SIMC1 | 375484 | RNAseq | 0.1513 | 0.4321 | |
| SRP133303 | SIMC1 | 375484 | RNAseq | 0.1304 | 0.3669 | |
| SRP159526 | SIMC1 | 375484 | RNAseq | 0.8898 | 0.0003 | |
| SRP193095 | SIMC1 | 375484 | RNAseq | -0.0765 | 0.6745 | |
| SRP219564 | SIMC1 | 375484 | RNAseq | 0.2088 | 0.6400 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SIMC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SIMC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIMC1 | 375484 | 2 | 13 | 15 | |
| GSE20123 | SIMC1 | 375484 | 2 | 13 | 15 | |
| GSE43470 | SIMC1 | 375484 | 1 | 11 | 31 | |
| GSE46452 | SIMC1 | 375484 | 0 | 27 | 32 | |
| GSE47630 | SIMC1 | 375484 | 0 | 20 | 20 | |
| GSE54993 | SIMC1 | 375484 | 10 | 2 | 58 | |
| GSE54994 | SIMC1 | 375484 | 2 | 17 | 34 | |
| GSE60625 | SIMC1 | 375484 | 1 | 0 | 10 | |
| GSE74703 | SIMC1 | 375484 | 1 | 7 | 28 | |
| GSE74704 | SIMC1 | 375484 | 1 | 6 | 13 | |
| TCGA | SIMC1 | 375484 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of SIMC1:
Generating mutation plots.
Highly correlated genes for SIMC1:
Showing top 20/84 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIMC1 | IPO5 | 0.726865 | 3 | 0 | 3 |
| SIMC1 | AAR2 | 0.726503 | 3 | 0 | 3 |
| SIMC1 | NEO1 | 0.709421 | 3 | 0 | 3 |
| SIMC1 | URI1 | 0.706643 | 3 | 0 | 3 |
| SIMC1 | C19orf12 | 0.692967 | 3 | 0 | 3 |
| SIMC1 | NTPCR | 0.692487 | 3 | 0 | 3 |
| SIMC1 | UBE2E3 | 0.688228 | 3 | 0 | 3 |
| SIMC1 | ZNF558 | 0.680768 | 3 | 0 | 3 |
| SIMC1 | ZNF32 | 0.678135 | 3 | 0 | 3 |
| SIMC1 | CENPJ | 0.676167 | 3 | 0 | 3 |
| SIMC1 | REPS2 | 0.67477 | 3 | 0 | 3 |
| SIMC1 | IFT27 | 0.668765 | 3 | 0 | 3 |
| SIMC1 | SPSB1 | 0.663749 | 3 | 0 | 3 |
| SIMC1 | TMEM185B | 0.653986 | 3 | 0 | 3 |
| SIMC1 | KRTAP4-1 | 0.648115 | 3 | 0 | 3 |
| SIMC1 | ZNF354A | 0.645832 | 3 | 0 | 3 |
| SIMC1 | HELZ | 0.641073 | 4 | 0 | 3 |
| SIMC1 | GORAB | 0.636995 | 3 | 0 | 3 |
| SIMC1 | GNA13 | 0.63281 | 3 | 0 | 3 |
| SIMC1 | HLTF | 0.632503 | 4 | 0 | 3 |
For details and further investigation, click here
