| Full name: SET domain containing 3, actin histidine methyltransferase | Alias Symbol: FLJ23027 | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 84193 | HGNC ID: HGNC:20493 | Ensembl Gene: ENSG00000183576 | OMIM ID: 615671 |
| Drug and gene relationship at DGIdb | |||
Expression of SETD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SETD3 | 84193 | 212465_at | -0.1102 | 0.7758 | |
| GSE20347 | SETD3 | 84193 | 212465_at | 0.0423 | 0.8036 | |
| GSE23400 | SETD3 | 84193 | 212465_at | 0.0425 | 0.4857 | |
| GSE26886 | SETD3 | 84193 | 212465_at | 0.0648 | 0.6701 | |
| GSE29001 | SETD3 | 84193 | 212465_at | 0.1911 | 0.2254 | |
| GSE38129 | SETD3 | 84193 | 212465_at | -0.2145 | 0.1458 | |
| GSE45670 | SETD3 | 84193 | 212465_at | -0.2370 | 0.0335 | |
| GSE53622 | SETD3 | 84193 | 78979 | -0.0596 | 0.5421 | |
| GSE53624 | SETD3 | 84193 | 78979 | 0.0020 | 0.9755 | |
| GSE63941 | SETD3 | 84193 | 212465_at | -0.3244 | 0.3768 | |
| GSE77861 | SETD3 | 84193 | 212465_at | -0.0712 | 0.7229 | |
| GSE97050 | SETD3 | 84193 | A_23_P25989 | -0.3080 | 0.3588 | |
| SRP007169 | SETD3 | 84193 | RNAseq | -0.3052 | 0.4189 | |
| SRP008496 | SETD3 | 84193 | RNAseq | -0.0291 | 0.9113 | |
| SRP064894 | SETD3 | 84193 | RNAseq | -0.0223 | 0.8335 | |
| SRP133303 | SETD3 | 84193 | RNAseq | 0.1939 | 0.1972 | |
| SRP159526 | SETD3 | 84193 | RNAseq | -0.1254 | 0.7332 | |
| SRP193095 | SETD3 | 84193 | RNAseq | -0.2310 | 0.0446 | |
| SRP219564 | SETD3 | 84193 | RNAseq | -0.4654 | 0.2771 | |
| TCGA | SETD3 | 84193 | RNAseq | -0.1075 | 0.0241 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SETD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SETD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SETD3 | 84193 | 10 | 5 | 15 | |
| GSE20123 | SETD3 | 84193 | 10 | 4 | 16 | |
| GSE43470 | SETD3 | 84193 | 7 | 4 | 32 | |
| GSE46452 | SETD3 | 84193 | 17 | 3 | 39 | |
| GSE47630 | SETD3 | 84193 | 11 | 8 | 21 | |
| GSE54993 | SETD3 | 84193 | 3 | 8 | 59 | |
| GSE54994 | SETD3 | 84193 | 21 | 4 | 28 | |
| GSE60625 | SETD3 | 84193 | 0 | 2 | 9 | |
| GSE74703 | SETD3 | 84193 | 6 | 3 | 27 | |
| GSE74704 | SETD3 | 84193 | 6 | 3 | 11 | |
| TCGA | SETD3 | 84193 | 31 | 19 | 46 |
Total number of gains: 122; Total number of losses: 63; Total Number of normals: 303.
Somatic mutations of SETD3:
Generating mutation plots.
Highly correlated genes for SETD3:
Showing top 20/309 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SETD3 | ZNF609 | 0.74616 | 3 | 0 | 3 |
| SETD3 | C9orf47 | 0.724105 | 3 | 0 | 3 |
| SETD3 | TAF7 | 0.717711 | 3 | 0 | 3 |
| SETD3 | IPO5 | 0.709883 | 3 | 0 | 3 |
| SETD3 | FCF1 | 0.705578 | 3 | 0 | 3 |
| SETD3 | CCDC59 | 0.70136 | 3 | 0 | 3 |
| SETD3 | PHYH | 0.700191 | 4 | 0 | 4 |
| SETD3 | CST5 | 0.694512 | 3 | 0 | 3 |
| SETD3 | ZNF79 | 0.692978 | 4 | 0 | 3 |
| SETD3 | RAMP1 | 0.685822 | 4 | 0 | 4 |
| SETD3 | KCNMB4 | 0.683386 | 3 | 0 | 3 |
| SETD3 | ZNF839 | 0.678309 | 4 | 0 | 3 |
| SETD3 | PIP5K1C | 0.677806 | 5 | 0 | 4 |
| SETD3 | ZNF540 | 0.675208 | 4 | 0 | 3 |
| SETD3 | PRICKLE1 | 0.67247 | 3 | 0 | 3 |
| SETD3 | GNB4 | 0.672298 | 4 | 0 | 3 |
| SETD3 | HMGN2 | 0.671465 | 4 | 0 | 4 |
| SETD3 | HSPB11 | 0.669951 | 4 | 0 | 3 |
| SETD3 | MAP4 | 0.668856 | 5 | 0 | 4 |
| SETD3 | PRKACA | 0.668856 | 4 | 0 | 3 |
For details and further investigation, click here
