| Full name: SUZ12 polycomb repressive complex 2 subunit | Alias Symbol: JJAZ1|KIAA0160|CHET9 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 23512 | HGNC ID: HGNC:17101 | Ensembl Gene: ENSG00000178691 | OMIM ID: 606245 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SUZ12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUZ12 | 23512 | 212287_at | 0.1508 | 0.4067 | |
| GSE20347 | SUZ12 | 23512 | 212287_at | 0.5550 | 0.0001 | |
| GSE23400 | SUZ12 | 23512 | 212287_at | 0.3103 | 0.0000 | |
| GSE26886 | SUZ12 | 23512 | 212287_at | -0.0172 | 0.9524 | |
| GSE29001 | SUZ12 | 23512 | 212287_at | 0.3488 | 0.0722 | |
| GSE38129 | SUZ12 | 23512 | 212287_at | 0.3610 | 0.0382 | |
| GSE45670 | SUZ12 | 23512 | 212287_at | 0.0383 | 0.8185 | |
| GSE53622 | SUZ12 | 23512 | 37104 | 0.1044 | 0.1439 | |
| GSE53624 | SUZ12 | 23512 | 37104 | 0.1835 | 0.0000 | |
| GSE63941 | SUZ12 | 23512 | 212287_at | 0.5834 | 0.0961 | |
| GSE77861 | SUZ12 | 23512 | 212287_at | 0.4856 | 0.0264 | |
| GSE97050 | SUZ12 | 23512 | A_23_P100883 | -0.0490 | 0.8676 | |
| SRP007169 | SUZ12 | 23512 | RNAseq | 0.6492 | 0.0403 | |
| SRP008496 | SUZ12 | 23512 | RNAseq | 0.2540 | 0.2559 | |
| SRP064894 | SUZ12 | 23512 | RNAseq | 0.0309 | 0.8849 | |
| SRP133303 | SUZ12 | 23512 | RNAseq | 0.4473 | 0.0003 | |
| SRP159526 | SUZ12 | 23512 | RNAseq | 0.3100 | 0.0428 | |
| SRP193095 | SUZ12 | 23512 | RNAseq | -0.0728 | 0.4487 | |
| SRP219564 | SUZ12 | 23512 | RNAseq | -0.1675 | 0.4768 | |
| TCGA | SUZ12 | 23512 | RNAseq | 0.0910 | 0.0678 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SUZ12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUZ12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUZ12 | 23512 | 9 | 2 | 19 | |
| GSE20123 | SUZ12 | 23512 | 8 | 2 | 20 | |
| GSE43470 | SUZ12 | 23512 | 1 | 1 | 41 | |
| GSE46452 | SUZ12 | 23512 | 33 | 1 | 25 | |
| GSE47630 | SUZ12 | 23512 | 7 | 1 | 32 | |
| GSE54993 | SUZ12 | 23512 | 2 | 3 | 65 | |
| GSE54994 | SUZ12 | 23512 | 7 | 6 | 40 | |
| GSE60625 | SUZ12 | 23512 | 4 | 0 | 7 | |
| GSE74703 | SUZ12 | 23512 | 1 | 1 | 34 | |
| GSE74704 | SUZ12 | 23512 | 6 | 2 | 12 | |
| TCGA | SUZ12 | 23512 | 20 | 10 | 66 |
Total number of gains: 98; Total number of losses: 29; Total Number of normals: 361.
Somatic mutations of SUZ12:
Generating mutation plots.
Highly correlated genes for SUZ12:
Showing top 20/805 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUZ12 | MYO5A | 0.778897 | 3 | 0 | 3 |
| SUZ12 | SIPA1L2 | 0.769246 | 3 | 0 | 3 |
| SUZ12 | MAPK6 | 0.763386 | 3 | 0 | 3 |
| SUZ12 | IPO5 | 0.759722 | 3 | 0 | 3 |
| SUZ12 | SMYD3 | 0.752745 | 5 | 0 | 5 |
| SUZ12 | ADAT1 | 0.743408 | 3 | 0 | 3 |
| SUZ12 | NAPEPLD | 0.734816 | 3 | 0 | 3 |
| SUZ12 | ANKFY1 | 0.726863 | 3 | 0 | 3 |
| SUZ12 | CDYL | 0.724898 | 3 | 0 | 3 |
| SUZ12 | PTER | 0.723839 | 3 | 0 | 3 |
| SUZ12 | AGTPBP1 | 0.718326 | 3 | 0 | 3 |
| SUZ12 | EIF1AX | 0.712356 | 3 | 0 | 3 |
| SUZ12 | MRPL24 | 0.710408 | 5 | 0 | 4 |
| SUZ12 | SIVA1 | 0.708614 | 4 | 0 | 3 |
| SUZ12 | SMS | 0.703749 | 4 | 0 | 4 |
| SUZ12 | ZC3H18 | 0.699881 | 3 | 0 | 3 |
| SUZ12 | ZNF317 | 0.698106 | 5 | 0 | 4 |
| SUZ12 | SLC35E1 | 0.697485 | 3 | 0 | 3 |
| SUZ12 | SMARCA5 | 0.690689 | 5 | 0 | 5 |
| SUZ12 | TCF12 | 0.68819 | 3 | 0 | 3 |
For details and further investigation, click here
