| Full name: poly(ADP-ribose) polymerase family member 8 | Alias Symbol: FLJ21308|pART16 | ||
| Type: protein-coding gene | Cytoband: 5q11.1 | ||
| Entrez ID: 79668 | HGNC ID: HGNC:26124 | Ensembl Gene: ENSG00000151883 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PARP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARP8 | 79668 | 219033_at | 0.1482 | 0.8451 | |
| GSE20347 | PARP8 | 79668 | 219033_at | -0.2452 | 0.3005 | |
| GSE23400 | PARP8 | 79668 | 219033_at | 0.0384 | 0.3747 | |
| GSE26886 | PARP8 | 79668 | 219033_at | 0.6972 | 0.0348 | |
| GSE29001 | PARP8 | 79668 | 219033_at | 0.0756 | 0.8346 | |
| GSE38129 | PARP8 | 79668 | 219033_at | -0.1365 | 0.4519 | |
| GSE45670 | PARP8 | 79668 | 219033_at | 0.0681 | 0.7647 | |
| GSE53622 | PARP8 | 79668 | 8189 | -0.2304 | 0.0209 | |
| GSE53624 | PARP8 | 79668 | 8189 | -0.1236 | 0.1996 | |
| GSE63941 | PARP8 | 79668 | 219033_at | -0.5110 | 0.6877 | |
| GSE77861 | PARP8 | 79668 | 219033_at | -0.3213 | 0.3314 | |
| GSE97050 | PARP8 | A_21_P0010775 | -0.1670 | 0.3708 | ||
| SRP007169 | PARP8 | 79668 | RNAseq | 0.1733 | 0.6985 | |
| SRP008496 | PARP8 | 79668 | RNAseq | -0.1149 | 0.7091 | |
| SRP064894 | PARP8 | 79668 | RNAseq | -0.0143 | 0.9407 | |
| SRP133303 | PARP8 | 79668 | RNAseq | -0.2407 | 0.1409 | |
| SRP159526 | PARP8 | 79668 | RNAseq | -0.6420 | 0.2055 | |
| SRP193095 | PARP8 | 79668 | RNAseq | -0.5458 | 0.0029 | |
| SRP219564 | PARP8 | 79668 | RNAseq | -0.2616 | 0.4646 | |
| TCGA | PARP8 | 79668 | RNAseq | -0.2408 | 0.0187 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PARP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARP8 | 79668 | 4 | 10 | 16 | |
| GSE20123 | PARP8 | 79668 | 4 | 10 | 16 | |
| GSE43470 | PARP8 | 79668 | 1 | 13 | 29 | |
| GSE46452 | PARP8 | 79668 | 0 | 27 | 32 | |
| GSE47630 | PARP8 | 79668 | 2 | 16 | 22 | |
| GSE54993 | PARP8 | 79668 | 8 | 1 | 61 | |
| GSE54994 | PARP8 | 79668 | 6 | 16 | 31 | |
| GSE60625 | PARP8 | 79668 | 0 | 0 | 11 | |
| GSE74703 | PARP8 | 79668 | 1 | 10 | 25 | |
| GSE74704 | PARP8 | 79668 | 4 | 4 | 12 | |
| TCGA | PARP8 | 79668 | 47 | 20 | 29 |
Total number of gains: 77; Total number of losses: 127; Total Number of normals: 284.
Somatic mutations of PARP8:
Generating mutation plots.
Highly correlated genes for PARP8:
Showing top 20/320 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARP8 | PMPCB | 0.790685 | 3 | 0 | 3 |
| PARP8 | NDUFA9 | 0.784714 | 3 | 0 | 3 |
| PARP8 | TMEM135 | 0.744211 | 3 | 0 | 3 |
| PARP8 | POLI | 0.740767 | 3 | 0 | 3 |
| PARP8 | SUB1 | 0.738009 | 3 | 0 | 3 |
| PARP8 | GPN3 | 0.737872 | 3 | 0 | 3 |
| PARP8 | MAK16 | 0.732654 | 3 | 0 | 3 |
| PARP8 | SMARCA5 | 0.728078 | 3 | 0 | 3 |
| PARP8 | WDR81 | 0.721365 | 3 | 0 | 3 |
| PARP8 | FAM200A | 0.721096 | 3 | 0 | 3 |
| PARP8 | PCNP | 0.721011 | 3 | 0 | 3 |
| PARP8 | HDAC3 | 0.71688 | 3 | 0 | 3 |
| PARP8 | CTCF | 0.712763 | 3 | 0 | 3 |
| PARP8 | GNGT2 | 0.711354 | 4 | 0 | 3 |
| PARP8 | RNF139 | 0.703073 | 3 | 0 | 3 |
| PARP8 | MLH1 | 0.697512 | 3 | 0 | 3 |
| PARP8 | MTO1 | 0.697436 | 4 | 0 | 3 |
| PARP8 | NNT | 0.697289 | 4 | 0 | 3 |
| PARP8 | BAG4 | 0.692211 | 3 | 0 | 3 |
| PARP8 | ORC5 | 0.691653 | 3 | 0 | 3 |
For details and further investigation, click here
