| Full name: ISL LIM homeobox 1 | Alias Symbol: Isl-1|ISLET1 | ||
| Type: protein-coding gene | Cytoband: 5q11.1 | ||
| Entrez ID: 3670 | HGNC ID: HGNC:6132 | Ensembl Gene: ENSG00000016082 | OMIM ID: 600366 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ISL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISL1 | 3670 | 206104_at | 0.2501 | 0.3019 | |
| GSE20347 | ISL1 | 3670 | 206104_at | 0.3117 | 0.2504 | |
| GSE23400 | ISL1 | 3670 | 206104_at | -0.3040 | 0.0006 | |
| GSE26886 | ISL1 | 3670 | 206104_at | 0.9520 | 0.0540 | |
| GSE29001 | ISL1 | 3670 | 206104_at | 0.2392 | 0.7036 | |
| GSE38129 | ISL1 | 3670 | 206104_at | -0.5326 | 0.1640 | |
| GSE45670 | ISL1 | 3670 | 206104_at | 0.1590 | 0.4421 | |
| GSE53622 | ISL1 | 3670 | 85349 | -0.1320 | 0.6992 | |
| GSE53624 | ISL1 | 3670 | 85349 | 0.0716 | 0.8179 | |
| GSE63941 | ISL1 | 3670 | 206104_at | 1.0864 | 0.3712 | |
| GSE77861 | ISL1 | 3670 | 206104_at | 0.0433 | 0.6472 | |
| GSE97050 | ISL1 | 3670 | A_23_P81529 | -0.2371 | 0.6228 | |
| TCGA | ISL1 | 3670 | RNAseq | -2.3368 | 0.0085 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ISL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISL1 | 3670 | 3 | 10 | 17 | |
| GSE20123 | ISL1 | 3670 | 3 | 10 | 17 | |
| GSE43470 | ISL1 | 3670 | 1 | 13 | 29 | |
| GSE46452 | ISL1 | 3670 | 0 | 27 | 32 | |
| GSE47630 | ISL1 | 3670 | 2 | 16 | 22 | |
| GSE54993 | ISL1 | 3670 | 8 | 1 | 61 | |
| GSE54994 | ISL1 | 3670 | 6 | 16 | 31 | |
| GSE60625 | ISL1 | 3670 | 0 | 0 | 11 | |
| GSE74703 | ISL1 | 3670 | 1 | 10 | 25 | |
| GSE74704 | ISL1 | 3670 | 3 | 4 | 13 | |
| TCGA | ISL1 | 3670 | 11 | 43 | 42 |
Total number of gains: 38; Total number of losses: 150; Total Number of normals: 300.
Somatic mutations of ISL1:
Generating mutation plots.
Highly correlated genes for ISL1:
Showing top 20/30 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISL1 | SLC16A1-AS1 | 0.680425 | 3 | 0 | 3 |
| ISL1 | CATSPER1 | 0.671785 | 3 | 0 | 3 |
| ISL1 | NGFR | 0.659204 | 3 | 0 | 3 |
| ISL1 | DEFB124 | 0.657541 | 3 | 0 | 3 |
| ISL1 | SLC20A2 | 0.643983 | 3 | 0 | 3 |
| ISL1 | PTGFR | 0.636817 | 3 | 0 | 3 |
| ISL1 | SALL1 | 0.614373 | 4 | 0 | 4 |
| ISL1 | METTL7B | 0.606604 | 3 | 0 | 3 |
| ISL1 | SIGLEC5 | 0.601031 | 3 | 0 | 3 |
| ISL1 | MAGEC2 | 0.59585 | 3 | 0 | 3 |
| ISL1 | CLPB | 0.589244 | 4 | 0 | 3 |
| ISL1 | WFDC1 | 0.58587 | 3 | 0 | 3 |
| ISL1 | PSMF1 | 0.582459 | 3 | 0 | 3 |
| ISL1 | DLX4 | 0.577047 | 5 | 0 | 3 |
| ISL1 | HAUS7 | 0.574961 | 4 | 0 | 3 |
| ISL1 | SAGE1 | 0.568874 | 5 | 0 | 3 |
| ISL1 | CDC25C | 0.56798 | 4 | 0 | 3 |
| ISL1 | OLIG3 | 0.565019 | 4 | 0 | 3 |
| ISL1 | FAM155A | 0.561414 | 4 | 0 | 3 |
| ISL1 | MSX2 | 0.559082 | 4 | 0 | 3 |
For details and further investigation, click here
