| Full name: ClpB homolog, mitochondrial AAA ATPase chaperonin | Alias Symbol: HSP78|SKD3|FLJ13152|ANKCLB | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 81570 | HGNC ID: HGNC:30664 | Ensembl Gene: ENSG00000162129 | OMIM ID: 616254 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CLPB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLPB | 81570 | 221845_s_at | 1.4205 | 0.0384 | |
| GSE20347 | CLPB | 81570 | 221845_s_at | 0.5837 | 0.0028 | |
| GSE23400 | CLPB | 81570 | 221845_s_at | 0.3253 | 0.0000 | |
| GSE26886 | CLPB | 81570 | 221845_s_at | 0.8959 | 0.0001 | |
| GSE29001 | CLPB | 81570 | 221845_s_at | 0.5551 | 0.0920 | |
| GSE38129 | CLPB | 81570 | 221845_s_at | 0.6792 | 0.0000 | |
| GSE45670 | CLPB | 81570 | 221845_s_at | 0.7873 | 0.0033 | |
| GSE53622 | CLPB | 81570 | 56258 | 0.6424 | 0.0000 | |
| GSE53624 | CLPB | 81570 | 56258 | 0.9400 | 0.0000 | |
| GSE63941 | CLPB | 81570 | 221845_s_at | 0.7133 | 0.1290 | |
| GSE77861 | CLPB | 81570 | 221845_s_at | 0.0888 | 0.4549 | |
| GSE97050 | CLPB | 81570 | A_23_P75978 | 0.3069 | 0.3074 | |
| SRP007169 | CLPB | 81570 | RNAseq | 0.7258 | 0.0948 | |
| SRP008496 | CLPB | 81570 | RNAseq | 0.7826 | 0.0112 | |
| SRP064894 | CLPB | 81570 | RNAseq | 1.1695 | 0.0000 | |
| SRP133303 | CLPB | 81570 | RNAseq | 1.1029 | 0.0062 | |
| SRP159526 | CLPB | 81570 | RNAseq | 0.2757 | 0.4463 | |
| SRP193095 | CLPB | 81570 | RNAseq | 0.7974 | 0.0000 | |
| SRP219564 | CLPB | 81570 | RNAseq | 1.1933 | 0.0250 | |
| TCGA | CLPB | 81570 | RNAseq | 0.0785 | 0.3332 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CLPB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLPB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLPB | 81570 | 10 | 7 | 13 | |
| GSE20123 | CLPB | 81570 | 10 | 7 | 13 | |
| GSE43470 | CLPB | 81570 | 9 | 5 | 29 | |
| GSE46452 | CLPB | 81570 | 12 | 17 | 30 | |
| GSE47630 | CLPB | 81570 | 10 | 10 | 20 | |
| GSE54993 | CLPB | 81570 | 7 | 3 | 60 | |
| GSE54994 | CLPB | 81570 | 11 | 13 | 29 | |
| GSE60625 | CLPB | 81570 | 0 | 7 | 4 | |
| GSE74703 | CLPB | 81570 | 7 | 4 | 25 | |
| GSE74704 | CLPB | 81570 | 7 | 4 | 9 | |
| TCGA | CLPB | 81570 | 36 | 19 | 41 |
Total number of gains: 119; Total number of losses: 96; Total Number of normals: 273.
Somatic mutations of CLPB:
Generating mutation plots.
Highly correlated genes for CLPB:
Showing top 20/538 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLPB | CD276 | 0.760788 | 4 | 0 | 4 |
| CLPB | TUBAL3 | 0.703314 | 4 | 0 | 4 |
| CLPB | LRR1 | 0.692481 | 7 | 0 | 7 |
| CLPB | CDCA5 | 0.683504 | 7 | 0 | 6 |
| CLPB | MTFP1 | 0.682698 | 5 | 0 | 5 |
| CLPB | ATAD3C | 0.681001 | 3 | 0 | 3 |
| CLPB | COL27A1 | 0.680716 | 6 | 0 | 5 |
| CLPB | ZFPM1 | 0.674961 | 3 | 0 | 3 |
| CLPB | FXYD4 | 0.672834 | 3 | 0 | 3 |
| CLPB | ATG16L1 | 0.671511 | 4 | 0 | 3 |
| CLPB | LRWD1 | 0.671259 | 3 | 0 | 3 |
| CLPB | NPW | 0.670606 | 4 | 0 | 4 |
| CLPB | CMSS1 | 0.663596 | 5 | 0 | 4 |
| CLPB | POLE4 | 0.661526 | 6 | 0 | 4 |
| CLPB | ZDHHC8 | 0.656711 | 4 | 0 | 4 |
| CLPB | TMX2 | 0.652738 | 8 | 0 | 7 |
| CLPB | RFX8 | 0.652589 | 3 | 0 | 3 |
| CLPB | EME1 | 0.650739 | 5 | 0 | 5 |
| CLPB | CDC6 | 0.64965 | 9 | 0 | 8 |
| CLPB | C16orf91 | 0.64694 | 4 | 0 | 3 |
For details and further investigation, click here
