| Full name: distal-less homeobox 4 | Alias Symbol: DLX8|BP1 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 1748 | HGNC ID: HGNC:2917 | Ensembl Gene: ENSG00000108813 | OMIM ID: 601911 |
| Drug and gene relationship at DGIdb | |||
Expression of DLX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLX4 | 1748 | 208216_at | 1.6819 | 0.1411 | |
| GSE20347 | DLX4 | 1748 | 208216_at | 0.5822 | 0.0148 | |
| GSE23400 | DLX4 | 1748 | 208216_at | 0.1428 | 0.0349 | |
| GSE26886 | DLX4 | 1748 | 208216_at | 1.2959 | 0.0000 | |
| GSE29001 | DLX4 | 1748 | 208216_at | 0.3992 | 0.4293 | |
| GSE38129 | DLX4 | 1748 | 208216_at | 0.8093 | 0.0004 | |
| GSE45670 | DLX4 | 1748 | 208216_at | 0.7768 | 0.0006 | |
| GSE53622 | DLX4 | 1748 | 20443 | 1.4192 | 0.0000 | |
| GSE53624 | DLX4 | 1748 | 20443 | 1.4758 | 0.0000 | |
| GSE63941 | DLX4 | 1748 | 208216_at | 1.6496 | 0.0219 | |
| GSE77861 | DLX4 | 1748 | 208216_at | 0.1772 | 0.3104 | |
| SRP159526 | DLX4 | 1748 | RNAseq | 2.6052 | 0.0001 | |
| SRP219564 | DLX4 | 1748 | RNAseq | 3.8619 | 0.0000 | |
| TCGA | DLX4 | 1748 | RNAseq | 2.4488 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by DLX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLX4 | 1748 | 5 | 2 | 23 | |
| GSE20123 | DLX4 | 1748 | 5 | 2 | 23 | |
| GSE43470 | DLX4 | 1748 | 3 | 2 | 38 | |
| GSE46452 | DLX4 | 1748 | 32 | 0 | 27 | |
| GSE47630 | DLX4 | 1748 | 9 | 0 | 31 | |
| GSE54993 | DLX4 | 1748 | 2 | 4 | 64 | |
| GSE54994 | DLX4 | 1748 | 9 | 6 | 38 | |
| GSE60625 | DLX4 | 1748 | 4 | 0 | 7 | |
| GSE74703 | DLX4 | 1748 | 3 | 2 | 31 | |
| GSE74704 | DLX4 | 1748 | 4 | 1 | 15 | |
| TCGA | DLX4 | 1748 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of DLX4:
Generating mutation plots.
Highly correlated genes for DLX4:
Showing top 20/482 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLX4 | MYH9 | 0.740186 | 3 | 0 | 3 |
| DLX4 | PTOV1 | 0.734406 | 3 | 0 | 3 |
| DLX4 | NPW | 0.703183 | 3 | 0 | 3 |
| DLX4 | SPRR2G | 0.677512 | 3 | 0 | 3 |
| DLX4 | KNSTRN | 0.673446 | 5 | 0 | 5 |
| DLX4 | SLCO1B3 | 0.669872 | 3 | 0 | 3 |
| DLX4 | EML6 | 0.653306 | 3 | 0 | 3 |
| DLX4 | KLC3 | 0.65249 | 3 | 0 | 3 |
| DLX4 | WDR54 | 0.649036 | 6 | 0 | 5 |
| DLX4 | SP4 | 0.647722 | 3 | 0 | 3 |
| DLX4 | ANGPT2 | 0.646944 | 3 | 0 | 3 |
| DLX4 | SLC7A5 | 0.643881 | 6 | 0 | 6 |
| DLX4 | ADAP1 | 0.639496 | 4 | 0 | 3 |
| DLX4 | TNNI3 | 0.638721 | 3 | 0 | 3 |
| DLX4 | DLX3 | 0.638326 | 4 | 0 | 3 |
| DLX4 | SCYL1 | 0.637403 | 3 | 0 | 3 |
| DLX4 | FOXO6 | 0.633877 | 4 | 0 | 3 |
| DLX4 | STRA6 | 0.63269 | 5 | 0 | 5 |
| DLX4 | CHD4 | 0.632156 | 3 | 0 | 3 |
| DLX4 | PSME4 | 0.630577 | 6 | 0 | 4 |
For details and further investigation, click here
