| Full name: sialic acid binding Ig like lectin 5 | Alias Symbol: OB-BP2|SIGLEC-5|CD170 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 8778 | HGNC ID: HGNC:10874 | Ensembl Gene: ENSG00000105501 | OMIM ID: 604200 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC5 | 8778 | 220000_at | 0.2765 | 0.6230 | |
| GSE20347 | SIGLEC5 | 8778 | 220000_at | 0.1175 | 0.3245 | |
| GSE23400 | SIGLEC5 | 8778 | 220000_at | -0.1090 | 0.0015 | |
| GSE26886 | SIGLEC5 | 8778 | 220000_at | 0.1581 | 0.2867 | |
| GSE29001 | SIGLEC5 | 8778 | 220000_at | -0.0938 | 0.4939 | |
| GSE38129 | SIGLEC5 | 8778 | 220000_at | -0.0515 | 0.7046 | |
| GSE45670 | SIGLEC5 | 8778 | 220000_at | 0.2035 | 0.0735 | |
| GSE63941 | SIGLEC5 | 8778 | 220000_at | 0.3416 | 0.0135 | |
| GSE77861 | SIGLEC5 | 8778 | 220000_at | -0.0121 | 0.9269 | |
| SRP064894 | SIGLEC5 | 8778 | RNAseq | 1.2475 | 0.0000 | |
| SRP133303 | SIGLEC5 | 8778 | RNAseq | 0.3616 | 0.2024 | |
| TCGA | SIGLEC5 | 8778 | RNAseq | 0.1931 | 0.5147 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SIGLEC5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC5 | 8778 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC5 | 8778 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC5 | 8778 | 3 | 12 | 28 | |
| GSE46452 | SIGLEC5 | 8778 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC5 | 8778 | 10 | 6 | 24 | |
| GSE54993 | SIGLEC5 | 8778 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC5 | 8778 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC5 | 8778 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC5 | 8778 | 3 | 8 | 25 | |
| GSE74704 | SIGLEC5 | 8778 | 3 | 1 | 16 | |
| TCGA | SIGLEC5 | 8778 | 14 | 19 | 63 |
Total number of gains: 114; Total number of losses: 72; Total Number of normals: 302.
Somatic mutations of SIGLEC5:
Generating mutation plots.
Highly correlated genes for SIGLEC5:
Showing top 20/907 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC5 | PADI4 | 0.734561 | 3 | 0 | 3 |
| SIGLEC5 | BRINP2 | 0.728018 | 4 | 0 | 4 |
| SIGLEC5 | HAUS5 | 0.709033 | 3 | 0 | 3 |
| SIGLEC5 | FOXN3-AS2 | 0.689881 | 5 | 0 | 5 |
| SIGLEC5 | HPX | 0.688508 | 7 | 0 | 7 |
| SIGLEC5 | CCZ1 | 0.684616 | 4 | 0 | 4 |
| SIGLEC5 | UBE2D4 | 0.683014 | 3 | 0 | 3 |
| SIGLEC5 | CCL16 | 0.682516 | 5 | 0 | 5 |
| SIGLEC5 | CD1B | 0.682292 | 5 | 0 | 5 |
| SIGLEC5 | NEUROD2 | 0.680175 | 5 | 0 | 4 |
| SIGLEC5 | NTNG1 | 0.678745 | 4 | 0 | 4 |
| SIGLEC5 | OPHN1 | 0.678664 | 4 | 0 | 4 |
| SIGLEC5 | OR1A1 | 0.673502 | 6 | 0 | 6 |
| SIGLEC5 | AMBN | 0.670258 | 6 | 0 | 5 |
| SIGLEC5 | CYSLTR2 | 0.66748 | 5 | 0 | 5 |
| SIGLEC5 | CYP2A7 | 0.665686 | 5 | 0 | 4 |
| SIGLEC5 | PYY | 0.661098 | 3 | 0 | 3 |
| SIGLEC5 | FOLH1 | 0.660853 | 5 | 0 | 4 |
| SIGLEC5 | FSCN3 | 0.660469 | 6 | 0 | 5 |
| SIGLEC5 | SULT2A1 | 0.660162 | 3 | 0 | 3 |
For details and further investigation, click here
