CDC25C

 

Full name: cell division cycle 25C Alias Symbol: PPP1R60
Type: protein-coding gene Cytoband: 5q31.2
Entrez ID: 995 HGNC ID: HGNC:1727 Ensembl Gene: ENSG00000158402 OMIM ID: 157680
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CDC25C involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation

 

Expression of CDC25C:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC25C 995 205167_s_at 0.9985 0.0259
GSE20347 CDC25C 995 216914_at 0.1030 0.2445
GSE23400 CDC25C 995 216914_at -0.0629 0.1600
GSE26886 CDC25C 995 205167_s_at 0.6837 0.0241
GSE29001 CDC25C 995 216914_at -0.1719 0.3480
GSE38129 CDC25C 995 205167_s_at 0.9564 0.0000
GSE45670 CDC25C 995 205167_s_at 0.9676 0.0001
GSE53622 CDC25C 995 69764 1.1909 0.0000
GSE53624 CDC25C 995 35496 1.9582 0.0000
GSE63941 CDC25C 995 205167_s_at 2.8334 0.0002
GSE77861 CDC25C 995 205167_s_at 0.2028 0.1588
GSE97050 CDC25C 995 A_23_P70249 0.5150 0.2124
SRP007169 CDC25C 995 RNAseq 1.6517 0.0109
SRP064894 CDC25C 995 RNAseq 2.2042 0.0000
SRP133303 CDC25C 995 RNAseq 2.2109 0.0000
SRP159526 CDC25C 995 RNAseq 1.5706 0.0002
SRP193095 CDC25C 995 RNAseq 0.9918 0.0000
SRP219564 CDC25C 995 RNAseq 2.1901 0.0076
TCGA CDC25C 995 RNAseq 1.6210 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by CDC25C expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC25C:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC25C 995 3 10 17
GSE20123 CDC25C 995 4 10 16
GSE43470 CDC25C 995 4 5 34
GSE46452 CDC25C 995 0 27 32
GSE47630 CDC25C 995 0 21 19
GSE54993 CDC25C 995 9 1 60
GSE54994 CDC25C 995 3 13 37
GSE60625 CDC25C 995 0 0 11
GSE74703 CDC25C 995 3 4 29
GSE74704 CDC25C 995 3 4 13
TCGA CDC25C 995 4 36 56

Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.  

 

Somatic mutations of CDC25C:

 

Generating mutation plots.

 

Highly correlated genes for CDC25C:

 

Showing top 20/1086 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC25CTGFB10.774226303
CDC25CKIF2C0.7600361009
CDC25CRET0.740013303
CDC25CNCAPH0.737051606
CDC25CPOLR1A0.736297303
CDC25CHJURP0.73506908
CDC25CFOLH10.730395303
CDC25CWDHD10.730188808
CDC25CTICRR0.729428606
CDC25CCENPA0.726837908
CDC25CSLC34A20.726236303
CDC25CNUF20.725288807
CDC25CKNSTRN0.723425706
CDC25CTK10.723112909
CDC25CDEPDC1B0.722997907
CDC25CKIF4A0.7222791008
CDC25CCENPK0.722224707
CDC25CKHDRBS20.720666303
CDC25CNCAPG0.718354707
CDC25CWDR540.716508606

For details and further investigation, click here