| Full name: msh homeobox 2 | Alias Symbol: CRS2|FPP|HOX8|MSH|PFM | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 4488 | HGNC ID: HGNC:7392 | Ensembl Gene: ENSG00000120149 | OMIM ID: 123101 |
| Drug and gene relationship at DGIdb | |||
Expression of MSX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSX2 | 4488 | 205555_s_at | 0.4368 | 0.3950 | |
| GSE20347 | MSX2 | 4488 | 205555_s_at | 0.2857 | 0.0029 | |
| GSE23400 | MSX2 | 4488 | 205555_s_at | 0.0568 | 0.0243 | |
| GSE26886 | MSX2 | 4488 | 205555_s_at | 0.5257 | 0.0001 | |
| GSE29001 | MSX2 | 4488 | 210319_x_at | 0.6423 | 0.0518 | |
| GSE38129 | MSX2 | 4488 | 205555_s_at | 0.2422 | 0.0441 | |
| GSE45670 | MSX2 | 4488 | 205555_s_at | 0.3920 | 0.0227 | |
| GSE53622 | MSX2 | 4488 | 45338 | 2.7076 | 0.0000 | |
| GSE53624 | MSX2 | 4488 | 45338 | 2.3246 | 0.0000 | |
| GSE63941 | MSX2 | 4488 | 205555_s_at | 1.5083 | 0.1419 | |
| GSE77861 | MSX2 | 4488 | 205555_s_at | 0.0026 | 0.9903 | |
| SRP007169 | MSX2 | 4488 | RNAseq | 2.0398 | 0.0204 | |
| SRP064894 | MSX2 | 4488 | RNAseq | 3.0614 | 0.0000 | |
| SRP133303 | MSX2 | 4488 | RNAseq | 3.9185 | 0.0000 | |
| SRP159526 | MSX2 | 4488 | RNAseq | 3.5329 | 0.0000 | |
| SRP219564 | MSX2 | 4488 | RNAseq | 2.9110 | 0.0010 | |
| TCGA | MSX2 | 4488 | RNAseq | 0.3571 | 0.0859 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by MSX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSX2 | 4488 | 2 | 12 | 16 | |
| GSE20123 | MSX2 | 4488 | 2 | 12 | 16 | |
| GSE43470 | MSX2 | 4488 | 1 | 10 | 32 | |
| GSE46452 | MSX2 | 4488 | 0 | 27 | 32 | |
| GSE47630 | MSX2 | 4488 | 0 | 20 | 20 | |
| GSE54993 | MSX2 | 4488 | 10 | 2 | 58 | |
| GSE54994 | MSX2 | 4488 | 2 | 17 | 34 | |
| GSE60625 | MSX2 | 4488 | 1 | 0 | 10 | |
| GSE74703 | MSX2 | 4488 | 1 | 7 | 28 | |
| GSE74704 | MSX2 | 4488 | 1 | 6 | 13 | |
| TCGA | MSX2 | 4488 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 148; Total Number of normals: 313.
Somatic mutations of MSX2:
Generating mutation plots.
Highly correlated genes for MSX2:
Showing top 20/689 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSX2 | ITGA11 | 0.710352 | 3 | 0 | 3 |
| MSX2 | WDR54 | 0.709513 | 5 | 0 | 5 |
| MSX2 | MRPS23 | 0.669407 | 5 | 0 | 5 |
| MSX2 | FNDC1 | 0.666324 | 4 | 0 | 3 |
| MSX2 | DCBLD1 | 0.664588 | 4 | 0 | 4 |
| MSX2 | MTHFD1L | 0.664396 | 3 | 0 | 3 |
| MSX2 | CDCA7L | 0.664296 | 4 | 0 | 3 |
| MSX2 | RCN3 | 0.662735 | 5 | 0 | 4 |
| MSX2 | TNFRSF18 | 0.660982 | 5 | 0 | 5 |
| MSX2 | SLC3A2 | 0.655583 | 6 | 0 | 6 |
| MSX2 | DCAF13 | 0.651259 | 3 | 0 | 3 |
| MSX2 | NOP14 | 0.648181 | 3 | 0 | 3 |
| MSX2 | IFT43 | 0.645955 | 5 | 0 | 5 |
| MSX2 | RHBDD2 | 0.643864 | 4 | 0 | 4 |
| MSX2 | PVR | 0.64333 | 3 | 0 | 3 |
| MSX2 | RNF2 | 0.642827 | 3 | 0 | 3 |
| MSX2 | ZNF469 | 0.641083 | 5 | 0 | 4 |
| MSX2 | MEX3B | 0.639697 | 4 | 0 | 3 |
| MSX2 | NAT14 | 0.636012 | 4 | 0 | 4 |
| MSX2 | GPR176 | 0.631762 | 5 | 0 | 5 |
For details and further investigation, click here
